Non-Randomized Study Protocols and Methods (Non-eHealth)

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Articles published in 2026 in this theme: 112 (scroll down to load remaining articles)

2026

Physical therapist assists patient with leg extension exercise on a therapy table.

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Evaluation of the Effectiveness of an Osseodensification System for Improvement in Bone Density After Delayed Implant Placement: Protocol for a Single-Arm Pilot Study

Rutuja Karamore, Prasad Dhadse, Ruchita Patil, Sanehi Punse

JMIR Res Protoc 2026 (Sep 01); 15:e80200

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Woman doing physical therapy exercises via video call with a therapist.

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Remote Assessment of Physical Function and Physical Activity in Adults With Autism Spectrum Disorder: Protocol for Feasibility, Validity, and Reliability Study

Annabel Nunez-Gaunaurd, Melissa M Tovin, Melissa Hale, Tan Li, Anjana Bhat

JMIR Res Protoc 2026 (Aug 31); 15:e86020

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Mother and smiling toddler at a pediatrician's office with a nurse

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Improving Proactive Primary Health Care After Gestational Diabetes: Protocol for Implementation and Evaluation of a Quality Improvement Collaborative Program in General Practice (GooD4Mum) and Baseline Practice Characteristics

Rachel Canaway, Samantha Kozica-Olenski, Anusha Ramani-Chander, Wendy Shepherdley, Sharleen O’Reilly, Tesfaye R Feyissa, Vincent Versace, Siew S Lim, Emily Callander, Melinda Morrison, Mark Morgan, Jane Speight, Douglas I R Boyle, Helena Teede

JMIR Res Protoc 2026 (Aug 28); 15:e89207

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Doctor in white coat consults with young male patient in beanie

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Clinical and Patient-Reported Outcomes Following Multidisciplinary Management of Cancer-Related Pain: Protocol for a Prospective Observational Pre-Post Study

Juan Jose Amate Pena, Laura García Reza, Patricia Concheiro-Moscoso, Betania Groba, Clara García Lorenzo, Miguel Angel Pereira Loureiro, Sara Sierra Cardalda

JMIR Res Protoc 2026 (Aug 27); 15:e92566

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Doctor examines young boy's throat with tongue depressor

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Unilateral Le Fort I Advancement Versus Dentoalveolar Transport Distraction in Patients With Large Alveolar Clefts: Protocol for a Prospective Observational Study

Kundan Shibjee Jha, Nitin Bhola

JMIR Res Protoc 2026 (Aug 25); 15:e77210

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Doctor reassures an older female patient in a clinic hallway.

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Psychological Factors and Personality Traits Influencing the Experience and Perception of Pain in Women Undergoing Mammography: Protocol for a Cross-Sectional Study

Irene Neophytou, George Charalambous, Eleni Jelastopulu

JMIR Res Protoc 2026 (Aug 25); 15:e92804

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Mental Health, Gender Dysphoria, and Quality of Life in Trans Individuals Following Top Surgery: Protocol for a Prospective Cohort Study

Julia Bak, Kah Aik Tan, Jack Ball, Sam Bonney, Julia K Moore, Blake S Cavve, Larissa Marion, Tim Hewitt, Sav Zwickl, Simone Mahfouda, Ashleigh Lin, Penelope Strauss, Kirsty Hird

JMIR Res Protoc 2026 (Aug 21); 15:e83928

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Mother kissing sleeping baby with pacifier

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Exploring the Early-Life Microbiomes of Preterm Infants and Their Childhood Health Outcomes (The BLOOM Study): Protocol for a Prospective, Observational Cohort Study

Marie-Claire Arrieta, Andrea Guedez, Catherine Lebel, Emily M Mercer, Fatimoh Kasaba, Gerald F Giesbrecht, Hussein Zein, James D Kellner, Jumana Samara, Lara M Leijser, Laura Sycuro, Luis Murguía Favela, Michelle R Asbury, Thierry Lacaze-Masmonteil, Zahra Rangipour, Jessica Lee, Kelly McNagny, Leonora Hendson, Belal Alshaikh

JMIR Res Protoc 2026 (Aug 18); 15:e95658

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Doctor holding brain graphic for CASCADE stroke study

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Effectiveness of a District-Level Comprehensive Acute Stroke Care Model for Management of Patients With Acute Stroke in Karnataka: Protocol for a Quasi-Experimental Study

Pradeep S Banandur, P R Srijithesh, Gautham Melur Sukumar, Arvind Banavaram, V S Binu, Nandakumar Dalavaikodihalli Nanjaiah, Santosh Loganathan, Thimappa Hegde, Komal Prasad C, Lavanya Garady, Aaheli Roy, Parama Basu, Deepika S Reddy, Arpitha Arun, Upashana Medhi

JMIR Res Protoc 2026 (Aug 14); 15:e93984

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Doctor reviews patient chart in a Rohingya refugee camp clinic

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Addressing Barriers to Health Care Access and Their Impact on Social Cohesion Among Rohingya Refugees and Host Community in Cox’s Bazar, Bangladesh: Protocol for a Qualitative Study

Samaha Masroor Saqib, Andreas Önver Cetrez, Soorej Jose Puthoopparambil

JMIR Res Protoc 2026 (Aug 14); 15:e89917

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Boy in black hoodie looking at colorful abstract art and children's drawings on a white wall.

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Art-Based Intervention to Promote Psychological Adjustment, Self-Concept, and Quality of Life in Children: Protocol for a Cluster Nonrandomized Controlled Trial

Sandra Henriques, Ricardo Pinto, Jorge Oliveira, Filipa Sampaio

JMIR Res Protoc 2026 (Aug 12); 15:e84994

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$Optical Quality of the Cornea After Orthokeratology Based on Total Corneal Refractive Power, Corneal Asphericity, and Epithelial Thickness: Protocol for a Prospective Quasi-Experimental Pre-Post Study$

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Optical Quality of the Cornea After Orthokeratology Based on Total Corneal Refractive Power, Corneal Asphericity, and Epithelial Thickness: Protocol for a Prospective Quasi-Experimental Pre-Post Study

José Licari, Alba Medico-Salsench, Laura Medina-Guijarro, César Villa-Collar, Cristina Rey-Reñones

JMIR Res Protoc 2026 (Aug 12); 15:e94476

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Woman with psoriasis preparing herbal remedies with mortar and pestle

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Efficacy and Safety of Integrated Traditional Chinese Medicine and Biologic Treatment in Moderate to Severe Atopic Dermatitis: Protocol for a Prospective Observational Real-World Study

Fanlingzi Shen, Ruiqi Cai, Jinrong Lu, Xiangjin Gao, Wencheng Jiang, Bin Li, Ruiping Wang

JMIR Res Protoc 2026 (Aug 07); 15:e96547

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Scientist tests tooth strength with mechanical testing machine, dental research

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The Fracture Resistance of Endodontically Treated Teeth Restored Using 3 Different Posts: Protocol for a Comparative Evaluation Study

Sanika Damle, Manoj Chandak, Vinus Shivlani

JMIR Res Protoc 2026 (Aug 07); 15:e76630

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Social worker talks with elderly man in a room with dog photos

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Identification of Training Needs and Development of a Work-Integrated Training Program for Aged Care On-Site Pharmacists: Protocol for a Co-Design Study

Tiernan McDonough, Amy Page, Lisa Kalisch Ellett, Christopher Etherton-Beer, Aaron Davis, Ian Gwilt, Jacinta Johnson

JMIR Res Protoc 2026 (Jul 31); 15:e95889

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Ultrasound probe scanning arm, showing muscle fibers and DNA helix

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Accuracy of Ultrasound-Guided Ulnar Perineural Subcutaneous Aspirate for the Diagnosis and Control of Leprosy: Protocol for a Prospective Diagnostic Evaluation Study

Claudia Maria Escarabel, Daniel Barroso, Patricia Alves Ponte Monteiro, Lúcia Helena Gomes Fernandes, Francyne Britto Funayama Papa, Mauro da Silva Rocha, Rodolfo Rêgo Deusdará Rodrigues, Ciro Martins Gomes, Neysa Aparecida Tinoco Regattieri

JMIR Res Protoc 2026 (Jul 29); 15:e86421

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Couple jogging in a park, holding water bottles and smiling

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Springfield Healthy Hearts Data Framework: Protocol for a Co-Designed, City-Wide, Multicomponent Initiative That Coordinates, Monitors, and Evaluates Place-Based Heart Health Action

Lauren Ball, Kirsten N Adlard, David Chua, Amy Kirkegaard, Genevieve N Healy, Sarah A McNaughton, Jason Ferris, Sonia Shah, George Thomas, Benjamin J Seligmann, Anne Bernard

JMIR Res Protoc 2026 (Jul 22); 15:e92825

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Two toddlers in rain gear explore a forest floor with leaves and small plants.

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Effect of an Outdoor-Focused Licensed Child Care Program on Child, Caregiver, and Educator Outcomes, Inclusion, and Accessibility: Protocol for the Sending Preschoolers Outside (SPROUT) Prospective Cohort Study

Maeghan James, Louise de Lannoy, Kelly P Arbour-Nicitopoulos, Alessia Capone, Lisa Belton, Kim Hiscott, Lisa Lalonde, Tammy Potter, Paula ter Huurne, Mark S Tremblay

JMIR Res Protoc 2026 (Jul 21); 15:e89405

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Medical team reviewing patient scans on laptop in radiology office

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Evaluating the Outcomes of the Capacity-Building Support From a Collaborative Network of Implementation Science Technical Assistance Hubs: Protocol for a Mixed Methods Evaluation

Sung-Jae Lee, Hannah Mestel, Carolyn M Audet, Bijal Balasubramanian, Nanette Benbow, Shruti Chandra, Carrie Geremia, Raul U Hernandez-Ramirez, Joyce L Jones, Olivia Keatley, Christopher Kemp, Christine M Khosropour, Robin Gaines Lanzi, Mary-Louise E Millett, Alexandra B Morshed, April C Pettit, Alec Powers, Borsika A Rabin, Jessica M Sales, Nicole A Stadnick, Debbie Humphries

JMIR Res Protoc 2026 (Jul 17); 15:e91374

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Two women meditating outdoors in a garden, one in focus

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The Effectiveness and Exploratory Cost-Effectiveness of Regular Meditation for Improving Quality of Life: Protocol for a Prospective Longitudinal Cohort Study

Lillian Ofori Ward, Cate Bailey, Prai Wattanatakulchat, Benjamin Stone, Alexander Burger, Deanna Kaplan, Santiago Jose Arconada Alvarez, Cullan Joyce, Ana Eclair, Nicholas T Van Dam, Julieta Galante

JMIR Res Protoc 2026 (Jul 17); 15:e85110

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