Non-Randomized Study Protocols and Methods (Non-eHealth)

Years in this theme: All years 2026 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012

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Articles published in this theme: 817 (scroll down to load remaining articles)

2026

Paramedic in face mask and stethoscope stands by open ambulance door.

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Systemwide Evaluation of Field Medicine Programs in Los Angeles County: Protocol for a Mixed Methods Longitudinal Observational Study

Randall Kuhn, Brian P Zunner-Keating, Sara Ozuna, Gisele Corletto, Geoffrey Cui-Naudet, Amanda Landrian Gonzalez, Sonali Saluja, Irene Del Mastro N, Jessie Chien, Catherine M Weaver, Charles Robinson, Coley King, Benjamin F Henwood

JMIR Res Protoc 2026 (Oct 14); 15:e94248

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Elderly woman in hospital bed with oxygen tube, speaking to doctor

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Geriatric Assessment–Based Stratification to Evaluate Treatment Intensity, Quality of Life, and Survival in Older Patients With Metastatic Colorectal Cancer: Protocol for a Prospective Observational Study

Takako Hiramatsu, Izumi Okazaki, Kyoko Hosokawa, Kazuhiko Yoshimatsu, Takeshi Nagasaka

JMIR Res Protoc 2026 (Oct 09); 15:e94561

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Chitosan Nanoparticles Combined With Titanium-Prepared Platelet-Rich Fibrin for Socket Preservation in Postextraction Sites: Protocol for a Single-Arm Clinical, Radiographic, and Histomorphometric Study

Rutuja Karamore, Prasad Dhadse, Sanehi Punse

JMIR Res Protoc 2026 (Oct 06); 15:e79532

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Two smiling young women with notebooks and a pencil on a bench.

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GENDER-Q Youth Patient-Reported Outcome Measure: Protocol for an International Cross-Sectional Field Test Study

Anne F Klassen, Charlene Rae, Shane D Morrison, Natasha Johnson, Karine Khatchadourian, Jack Graesser, Manraj N Kaur

JMIR Res Protoc 2026 (Oct 05); 15:e100420

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Doctor analyzes liver health data on France map with charts and laptop

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RESONANCE: Protocol for a Nationwide Cohort Study of Chronic Liver Diseases Using the French National Health Data System

Aurore Baron, Frédéric Balusson, Laure Tron, Vaele Zannou, Anne Ego, Anna Borowick, Thomas Decaens, Emmanuel Oger, Sébastien Bailly, Charlotte Costentin, Victoria Mignot

JMIR Res Protoc 2026 (Oct 05); 15:e89577

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Four friends laughing and socializing on a couch with drinks and snacks

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Investigating the Effects of Paralinguistic Configuration in Background Human Speech on Attention: Protocol for a Within-Subject Study

Zilu Liang, Carl Daniel Karlsson

JMIR Res Protoc 2026 (Sep 30); 15:e93525

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Doctor listens to patient's cough with stethoscope during medical exam

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Preoperative Carriage of Respiratory Viruses and Acute Respiratory Distress Syndrome After Cardiac Surgery: Protocol for the VIRUS-ATTAC Prospective Cohort Study

Nicolas Nesseler, Adrien Bouglé, Nicolas Mongardon, Bertrand Rozec, Thomas Kerforne, Chloé Rousseau, Erwan Flécher, Jean-Philippe Verhoye, Mathieu Beaudeau, James Terriss Ross, Marie-Laure Gervais, Claire Fougerou-Leurent, Pierre Tattevin, Vincent Thibault, Célia Pilon, Charlotte Pronier, Alexandre Mansour

JMIR Res Protoc 2026 (Sep 30); 15:e103466

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Overhead view of a delicious Mediterranean mezze platter with various dishes

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Exploring Perceived Barriers and Facilitators to Healthier and More Sustainable Dietary Behavior in 27 European Countries: Protocol for a Cross-Sectional Survey

Anna Maria Murante, Federica Manca, Fabio Consalez, Chiara Chirilli, Luisa Torri, Anant Jani, Agustin Miranda, Eric Verger, Catalina Leon Gonzalez, Maria Piochi, Maria Giovanna Onorati, Susana Campos, Ana Teresa Ferreira Oliveira, Janas Harrington, Valeria Massei, Chiara Ferravante, Tim Smits, Yara Qutteina, Kabi Vanwinkelen, Annemarie Kapteijns, Leonie Barelds-Cramer, Aleksandra Różalska, Aditi Bunker, Till Bärnighausen

JMIR Res Protoc 2026 (Sep 30); 15:e91985

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Medical professional analyzing lab results on a computer screen

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The Role of Human Leukocyte Antigen (HLA) Allele Patterns in the Incidence of End-Stage Renal Disease and HLA Antibody Production: Protocol for a Case-Control Study

Ira Puspitawati, Nyoman Kertia, Teguh Triyono

JMIR Res Protoc 2026 (Sep 30); 15:e107508

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Flowchart of the CAFFE study on persistent atrial fibrillation in older patients and its impact on physical performance and frailty.

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Effects of Rhythm Control versus Rate Control on Atrial Fibrillation and Frailty Development in Older Patients: Protocol for the Cardioversion of Atrial Fibrillation and Frailty in the Elderly (CAFFE) Study, an Observational, Prospective Cohort Study

Elisa Berni, Veronica De Angelis, Emanuele Santamaria, Alessandro Mengozzi, Claudia Di Serio, Giulia Spanalatte, Michele Biagioli, Arianna Tariello, Marta Niccolini, Camilla Cagnoni, Djullye Miduri Da Silva Nakano, Giada Alla Viligiardi, Marco Capacci, Andrea Ungar, Giancarlo La Marca, Igor Diemberger, Agostino Virdis, Stefano Fumagalli

JMIR Res Protoc 2026 (Sep 29); 15:e92572

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$Optometrist using an auto refractometer to examine a patient's eyes$

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Corneal Astigmatism Outcomes After Simultaneous Pterygium Excision Using The Bare Sclera Technique and Manual Small Incision Cataract Surgery: Protocol for a Prospective Single-Arm Pre-Post Interventional Cohort Study

Akshaya Tandle, Kanchan Selukar

JMIR Res Protoc 2026 (Sep 23); 15:e96749

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Nutritionist discusses healthy eating with a client, showing an apple.

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The Effects of Autonomy-Enhancing Therapy for Eating Disorders: Protocol for a Single-Case Experimental Multiple Baseline Design

Nicky Bosman, Joyce Maas, Marcel van Assen, Mladena Simeunovic-Ostojic, Marrie Bekker

JMIR Res Protoc 2026 (Sep 22); 15:e87349

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People exercising on red mats with sensors in a gym

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The Effect of Integrated Aerobic and Cognitive Training (Activ4Brain) on Cognition and Neurophysiology in Older Adults: Protocol for a Controlled Trial

Hicran Besikci, Kaan Akalp, Luís Rama, Beatriz Branquinho Gomes, José Pedro Leitão Ferreira, Susana Mouga, Inês Bernardino, Miguel Castelo-Branco, Ana Rita Sousa e Silva, Ana Maria Teixeira, Maria José Ribeiro

JMIR Res Protoc 2026 (Sep 17); 15:e92631

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Scientist holding a test tube with liquid and a wire in a lab

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Comparative Evaluation of Silver Dioxide–Coated and Noncoated Stainless Steel Wires for Susceptibility to Corrosion: Protocol for an In Vitro Study

Aishwarya Atey, Rizwan Gilani, Shefali Singh, Abhijeet Kadam

JMIR Res Protoc 2026 (Sep 08); 15:e74309

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Person using a laptop for an online wellness assessment

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Development, Implementation, and Evaluation of a Prevention Model of Care in South West Queensland (Wellness my Way): Protocol for a Pilot Implementation Study

Claudia I Maddren, Clare Johnson, Tahlia Alsop, Madeline Forbes, Li Kheng Chai, Joanne Isbel, Kathy Morrow, Joanna Munro, Clare Murray, Shelley Peardon-Freeman, Claudia Regan-Knights, Helen Wassman, Sjaan R Gomersall

JMIR Res Protoc 2026 (Sep 03); 15:e98966

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Physical therapist assists patient with leg extension exercise on a therapy table.

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Evaluation of the Effectiveness of an Osseodensification System for Improvement in Bone Density After Delayed Implant Placement: Protocol for a Single-Arm Pilot Study

Rutuja Karamore, Prasad Dhadse, Ruchita Patil, Sanehi Punse

JMIR Res Protoc 2026 (Sep 01); 15:e80200

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Woman doing physical therapy exercises via video call with a therapist.

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Remote Assessment of Physical Function and Physical Activity in Adults With Autism Spectrum Disorder: Protocol for Feasibility, Validity, and Reliability Study

Annabel Nunez-Gaunaurd, Melissa M Tovin, Melissa Hale, Tan Li, Anjana Bhat

JMIR Res Protoc 2026 (Aug 31); 15:e86020

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Mother and smiling toddler at a pediatrician's office with a nurse

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Improving Proactive Primary Health Care After Gestational Diabetes: Protocol for Implementation and Evaluation of a Quality Improvement Collaborative Program in General Practice (GooD4Mum) and Baseline Practice Characteristics

Rachel Canaway, Samantha Kozica-Olenski, Anusha Ramani-Chander, Wendy Shepherdley, Sharleen O’Reilly, Tesfaye R Feyissa, Vincent Versace, Siew S Lim, Emily Callander, Melinda Morrison, Mark Morgan, Jane Speight, Douglas I R Boyle, Helena Teede

JMIR Res Protoc 2026 (Aug 28); 15:e89207

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Doctor in white coat consults with young male patient in beanie

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Clinical and Patient-Reported Outcomes Following Multidisciplinary Management of Cancer-Related Pain: Protocol for a Prospective Observational Pre-Post Study

Juan Jose Amate Pena, Laura García Reza, Patricia Concheiro-Moscoso, Betania Groba, Clara García Lorenzo, Miguel Angel Pereira Loureiro, Sara Sierra Cardalda

JMIR Res Protoc 2026 (Aug 27); 15:e92566

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Doctor examines young boy's throat with tongue depressor

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Unilateral Le Fort I Advancement Versus Dentoalveolar Transport Distraction in Patients With Large Alveolar Clefts: Protocol for a Prospective Observational Study