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Ongoing Trials, Grant Proposals, Formative Research, Methods, Early Results
JMIR Research Protocols (ISSN 1929-0748) publishes peer-reviewed, openly accessible research ideas and grant proposals, study and trial protocols, reports of ongoing research, current methods and approaches, and preliminary results from pilot studies or formative research informing the design of medical and health-related research and technology innovations.
JMIR Res Protoc is a new journal spin-off of JMIR, the worlds' leading medical journal in health sciences / health services research and health informatics (Impact Factor 2016: 5.175)
JMIR Res Protoc publishes protocols and grant proposals in all areas of medicine (and their peer-review reports, if available), as well as feasibility studies, early reports and formative/process evaluations of ongoing studies and descriptions of the development and pilot evaluations of innovations and software applications or other interventions
JMIR Res Protoc is fully open access, with full text articles deposited in PubMed Central
Publishing research protocols, grant proposals, pilot/feasibility studies and early reports of ongoing and planned work encourages collaboration and early feedback, and reduces duplication of effort
JMIR Res Protoc will be a valuable ressource for researchers who want to learn about current research methodologies and how to write a winning grant proposal
JMIR Res Protoc creates an early scientific record for researchers who have developed novel methodologies, software, innovations or elaborate protocols
JMIR Res Protoc faciliates subsequent publication of results demonstrating that the methodology has already been reviewed, and reduces the effort of writing up the results, as the protocol can be easily referenced
JMIR Res Protoc demonstrates to reviewers of subsequent results papers that authors followed and adhered to carefully developed and described a-priori methods
Studies whose protocols or grant proposal have been accepted in JMIR Res Protoc are "in principle accepted" for subsequent publication of results in other JMIR journals as long as authors adhere to their original protocol - regardless of study results (even if they are negative), reducing publication bias in medicine
Authors publishing their protocols in JMIR Res Protoc will receive a 20% discount on the article processing fee if they publish their results in another journal of the JMIR journal family (for example, JMIR for ehealth studies, i-JMR for others)
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Background: Although many mHealth interventions have shown efficacy in research, few have been effectively implemented and sustained in real-world health system settings. Despite this programmatic gap...
Background: Although many mHealth interventions have shown efficacy in research, few have been effectively implemented and sustained in real-world health system settings. Despite this programmatic gap, there is limited conclusive evidence identifying the factors that affect the implementation and successful integration of mHealth into a health system. Objective: The purpose of this study is to examine the individual, organizational and external level factors associated with the successful implementation of WelTel, mHealth intervention designed to support outpatient medication adherence and engagement in care in Africa and North America. Methods: We will adapt the Consolidated Framework for Implementation Research (CFIR) constructs for evaluation of digital healthcare implementation including a scoring and monitoring system. We will apply the adapted tool to identify facilitators and barriers to implementation of the WelTel mHealth intervention in order to determine how the technology platform is perceived, diffused, adapted and used by different mHealth project teams and health system actors in Africa and North America. We will utilize a mixed-methods approach to quantitatively test whether the factors identified in the CFIR framework are associated with the successful uptake of the mHealth intervention toward implementation goals. We will triangulate these data through interviews with project stakeholders, exploring factors associated with successful implementation and sustainment of these interventions. Results: The results of this study will provide an in-depth understanding of individual- and organizational-level factors that influence the successful implementation of mHealth in different health systems and geographic contexts over time. Via the tool’s unique scoring system connected to qualitative descriptors, these data will inform the most critical implementation targets and contribute to the tailoring of strategies that will assist the health system in overcoming barriers to implementation, and ultimately, improve treatment adherence and engagement in care. Conclusions: The results of this study will provide an in-depth understanding of individual- and organizational-level factors that influence the successful implementation of mHealth in different health systems and geographic contexts over time. Via the tool’s unique scoring system connected to qualitative descriptors, these data will inform the most critical implementation targets and contribute to the tailoring of strategies that will assist the health system in overcoming barriers to implementation, and ultimately, improve treatment adherence and engagement in care.
The Specialised Services Pathway for Severe Asthma (NHS Commissioning Board, 2012/2013) recognises the burden of uncontrolled disease, ordinarily amenable to anti-inflammatory medications and the prog...
The Specialised Services Pathway for Severe Asthma (NHS Commissioning Board, 2012/2013) recognises the burden of uncontrolled disease, ordinarily amenable to anti-inflammatory medications and the progression to longer term ‘severe’ disease necessitating high-cost therapies (e.g. Bronchial Thermoplasty). The identification and appropriate referral to a specialist asthma service is often delayed by several months or years due to poor recognition and understanding of symptom severity. Current severe asthma services may take several months to provide a comprehensive multi-disciplinary assessment often necessitating multiple hospital visits and costing up to £5000 per patient. MISSION – Modern Innovative Solutions to Improve Outcomes in Severe Asthma is a novel service model pilot developed by asthma specialists from Portsmouth and Southampton asthma services. MISSION Severe Asthma identified patients with poorly controlled disease from General Practice (GP) databases who had not been under secondary outpatient care in the last 12 months or who were not known to secondary care. In one-or two-stop assessments, a thorough review of diagnosis, disease phenotype and control is undertaken. This Protocol outlines a mixed methods study to assess the impact on disease control, unscheduled healthcare usage and quality of life in patients seen in the MISSION clinic compared to a closely matched cohort who declined to attend.
Background: Significant benefits accrue from increasing physical activity levels in people with a history of cancer. Physical activity levels can be increased using behavioural change interventions in...
Background: Significant benefits accrue from increasing physical activity levels in people with a history of cancer. Physical activity levels can be increased using behavioural change interventions in this population. Access to web-portals and provision of activity monitors to provide feedback may support behaviour change by encouraging patient engagement in physical therapy. The web-portal evaluated in this study will provide a system to monitor physical activity and sleep, for use by both clinician and patient, along with symptom and health related quality of life tracking capabilities. Objective: To evaluate the feasibility of a web-based portal that provides activity monitoring and personalised messaging to increase physical activity in people with cancer. Methods: Using a longitudinal cohort design, people with cancer will be serially allocated to three intervention cohorts and followed for 10 weeks. Group 1 will be provided a wearable activity monitor and access to a web-based portal. Group 2 will receive the same as group 1 and in addition will receive a weekly activity summary message. Group 3 will receive the same as Group 1 and 2 and in addition will receive a personalised weekly coaching message. Feasibility of the use of the portal is the primary outcome. Results: Expected in February 2018 Conclusions: The study findings will provide information about the relative effects of eHealth initiatives to facilitate physical activity behavioural change in people with cancer.
Background: Dyslexia is a lifelong problem affecting up to 1 in 10 to 20 people in the UK, and as the most common learning difficulty puts immense pressure on already over-stretched public finances. O...
Background: Dyslexia is a lifelong problem affecting up to 1 in 10 to 20 people in the UK, and as the most common learning difficulty puts immense pressure on already over-stretched public finances. Our aim is to create a digital health solution that will radically improve dyslexia detection at an early stage and self-management. This is expected to reduce intervention costs, improve quality of life for sufferers and enable them to be more independent. Objective: We discuss the rationale and protocol for the design and development of a digital health tool aimed at improving the early detection, monitoring and management of dyslexia (DIMMAND) in young children (4 to 8 years). This will be delivered using a game-based digital app aimed at children, parents and teachers. It will firstly assess, then monitor and manage progress in a convenient, cost-effective and private environment. Methods: The proposed app will be designed and developed in two stages. In the first stage (already underway), the full functional specification of the games that constitute the app will be designed, together with the overall architecture of the app. Prototype proof-of-concept implementation for several of these games, and commercialization strategies will also be developed. The (proposed) second stage will see the design implemented into a fully-fledged app. Results: The project has commenced in March 2017. The final outcomes of the first stage will be available in March 2018. Conclusions: DIMMAND has the potential to provide significant positive healthcare and economic impact. It is expected to reduce intervention costs, improve dyslexia detection at an early stage and aid self-management.
Background: People living with a substance use disorder (SUD) are a key population within the hepatitis C virus (HCV) epidemic. While integrated and community-based models of care have shown positive...
Background: People living with a substance use disorder (SUD) are a key population within the hepatitis C virus (HCV) epidemic. While integrated and community-based models of care have shown positive outcomes among this population, the literature has been primarily focused on the human immunodeficiency virus (HIV) context. This paper outlines a systematic review protocol on the impact of various integrated models of care, which includes HCV and SUD services, on various treatment, and health-related outcomes among this population. Objective: Determine the impact of the impact of integrated models of care on HCV and addiction treatment and health-related outcomes for adults living with HCV and a SUD. Methods: We will search a total of five databases, article reference lists, and abstracts from relevant conferences that investigate the impact of integrated models of care on treatment and health-related outcomes among people living with HCV and a SUD. Database searches will be conducted and titles, abstracts, and full-text will be independently reviewed in separate stages. The methodological quality of included quantitative research studies will be assessed using a validated tool. Data from included articles will be extracted using a standardized form and synthesized in a narrative account. Conclusions: The systematic review will describe different integrated models of care that could be effective in improving the health and well-being of people living with HCV and a SUD. Results of this review could also identify quality improvement strategies to minimize the health and cost burden imposed on patients, healthcare professionals, and the healthcare system. Systematic Review Registration: PROSPERO CRD42017078445
Large scale primary data collections are complex, costly, and time consuming. Study protocols for trial based research are now commonplace with a growing number of similar pieces of work being publis...
Large scale primary data collections are complex, costly, and time consuming. Study protocols for trial based research are now commonplace with a growing number of similar pieces of work being published on observational research. However, a likely useful addition to the literature base are publications that describe the issues and challenges faced whilst conducting observational studies. These can provide researchers with insightful knowledge that can inform funding proposals or project development work. The SPACES (Studying Physical Activity in Children’s Environments across Scotland) study was designed to collect objectively measured physical activity and Global Positioning System (GPS) data from 10/11 year old children across Scotland, using a postal delivery method. In this paper we identify and reflectively discuss the unforeseen or often unpublished issues associated with organising and implementing a large scale objectively measured physical activity and GPS data collection. The three main phases of the project (recruitment, delivery of project materials, and data collection and processing) are described within a two stage framework: (i) intended design and (ii) implementation of the intended design. Unanticipated challenges arose that influenced the data collection process, and encompass four main impact categories: i) cost, budget and funding; ii) project timeline; iii) participation/engagement; and iv) data challenges. The main unforeseen issues that impacted our timeline included: the informed consent process for children under the age of 18; the use of, and coordination with, the postal service to deliver study information and equipment; the variability associated with when participants began the data collection and the time taken to send devices and consent forms back (1 – 12 months). Unanticipated budgetary issues included the identification of some study materials (AC power adapter) not fitting through letterboxes, and the employment of fieldworkers to increase recruitment and the return of consent forms. Finally, we encountered data issues when processing physical activity and GPS data that had been initiated across Daylight Savings Time (DST). We present learning points and recommendations that may benefit future studies of similar methodology in their early stages of development.