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Ongoing Trials, Grant Proposals, Formative Research, Methods, Early Results
JMIR Research Protocols (ISSN 1929-0748) is a unique Pubmed-indexed journal, publishing peer-reviewed, openly accessible research ideas and grant proposals, study and trial protocols, reports of ongoing research, current methods and approaches, and preliminary results from pilot studies or formative research informing the design of medical and health-related research and technology innovations.
JMIR Res Protoc is a journal spin-off of JMIR, the worlds' leading medical journal in health sciences / health services research and health informatics (JMIR Impact Factor 2017: 4.671).
While the original focus was on eHealth studies, JMIR Res Protoc now publishes protocols and grant proposals in all areas of medicine (and their peer-review reports, if available), as well as feasibility studies, early reports and formative/process evaluations of ongoing studies and descriptions of the development and pilot evaluations of innovations and software applications or other interventions.
JMIR Res Protoc is fully open access, with full text articles deposited in PubMed Central.
Publishing research protocols, grant proposals, pilot/feasibility studies and early reports of ongoing and planned work encourages collaboration and early feedback, and reduces duplication of effort.
JRP is compatible with the concept of "Registered Reports" and since May 2018, published protocols receive a Registered Report Identifier (What is a Registered Report Identifier?) and acceptance of the subsequent results paper is "in principle" guaranteed in any JMIR journal and partner journals - see What is a Registered Report?.
JMIR Res Protoc will be a valuable ressource for researchers who want to learn about current research methodologies and how to write a winning grant proposal.
JMIR Res Protoc creates an early scientific record for researchers who have developed novel methodologies, software, innovations or elaborate protocols.
JMIR Res Protoc provides a "dry-run" for peer-review of the final results paper, and allows feedback/critique of the methods, often while they still can be fixed.
JMIR Res Protoc faciliates subsequent publication of results demonstrating that the methodology has already been reviewed, and reduces the effort of writing up the results, as the protocol can be easily referenced.
JMIR Res Protoc demonstrates to reviewers of subsequent results papers that authors followed and adhered to carefully developed and described a-priori methods.
Studies whose protocols or grant proposal have been accepted in JMIR Res Protoc are "in principle accepted" for subsequent publication of results in other JMIR journals as long as authors adhere to their original protocol - regardless of study results (even if they are negative), reducing publication bias in medicine.
Authors publishing their protocols in JMIR Res Protoc will receive a 20% discount on the article processing fee if they publish their results in another journal of the JMIR journal family (for example, JMIR for ehealth studies, i-JMR for others).
JMIR Res Protoc is also a unique crowdfunding platform, allowing backers to crowdfund carefully peer-reviewed projects that are not junk-science, and giving researchers additional small funding to conduct and publish their research results. Each article is published with a crowdfunding widget, allowing readers to make nominal donations to the project, which benefit the authors (currently in beta).
Need more reasons? Read the Knowledge Base article on "Why should I publish my protocol/grant proposal"!
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Background: Primary, specialist and allied health services can assist in providing equitable access in rural and remote areas where higher proportions of Aboriginal and Torres Strait Islander people (...
Background: Primary, specialist and allied health services can assist in providing equitable access in rural and remote areas where higher proportions of Aboriginal and Torres Strait Islander people (Aboriginal Australians) reside to overcome high rates of chronic disease experienced by this population group. Little is currently known about the location and frequency of services and the extent to which providers believe delivery is occurring in a sustained and coordinated manner. Objective: To determine the availability, accessibility and level of coordination of a range of community-based healthcare services to Aboriginal people and identify potential barriers in accessing healthcare services from the perspectives of the health service providers. Methods: This mixed-methods study will take place in three de-identified communities in New South Wales selected for their high population of Aboriginal people and geographical representation of particular location type (coastal, rural and border). The study is designed and conducted in collaboration with communities, Aboriginal Community Controlled Health Services (ACCHSs) and other local health services. Data collection will involve face to face and telephone interviews. Participants will be recruited through snowball sampling and will answer structured, quantitative questions about the availability and accessibility of primary healthcare, specialist medical and allied health services and qualitative questions about accessing services. Quantitative data analysis will determine the frequency and accessibility of specific services across each community. Qualitative data will be analyzed thematically to identify issues relating to availability, accessibility and coordination. The quantitative and qualitative data will then be combined and analyzed using a health ecosystems approach. Results: Twenty eight stakeholder participants across the ACCHSs were identified for recruitment through snowball sampling (N=4 coastal, N=12 rural and N=12 border) for data collection. Conclusions: The study will determine the scope and level of coordination of primary, specialist and allied health services in rural communities with high Aboriginal populations from the perspectives of service providers from those communities. Identification of factors affecting availability, accessibility and coordination of services can assist ways of developing and implementing culturally sensitive service delivery. These findings will inform recommendations for the provision of health services for Aboriginal people in rural and remote settings. The study will also contribute to the broader literature of rural and remote health service provision.
Background: Diabetes (T2DM) is a growing global burden with T2DM expected to affect more than 590million people by the year 2035. Evidence exists demonstrating that dental settings have been used to t...
Background: Diabetes (T2DM) is a growing global burden with T2DM expected to affect more than 590million people by the year 2035. Evidence exists demonstrating that dental settings have been used to try and risk assess and identify individuals who may be at high risk of T2DM or who may already unknowingly have the condition. Objective: This protocol aims to outline the methodology which will be undertaken in order to synthesise the literature relating to the use of primary-care, (non-hospital based) dental services for the identification of undiagnosed T2DM or prediabetes - often termed non-diabetic hyperglycaemia (NDH), in adult patients. Methods: This paper outlines the protocol that will be followed to conduct a systematic review and meta-analysis of the available literature. The protocol outlines the aims, objectives, search strategy, data extraction and data management methods, as well as the statistical analysis plan. Prisma-P guidelines were followed in developing the protocol as were elements of the Cochrane handbook. Results: It is anticipated the included studies will demonstrate high levels of heterogeneity resulting in a descriptive synthesis approach to the analysis of results. The descriptive synthesis will be structured around the primary and secondary outcomes of the review. Conclusions: This systematic review will provide evidence on the identification of patients with NDH or T2DM using risk assessment methods, in dental care settings. Additional outcomes include: identification of methodologies utilised within the dental practice for case-finding, establishing recruitment rates within the studies and gaining insight into the opinions of patients and healthcare professionals relating to case-finding. The review will also aim to enhance the understanding of reported barriers to uptake of any such implemented services and reported any identified benefits to utilising dental settings to case find NDH and T2DM. Clinical Trial: Dissemination Following publication of the protocol the review will be registered on PROSPERO. Following completion of the review, results will be published in a suitable peer-reviewed journal.
Background: Across Europe, Canada, Australia, and the United States, prevalence of home mechanical ventilation (HMV) ranges from 6.6 to 12.0 per 100,000. Ventilator-assisted individuals (VAIs) living...
Background: Across Europe, Canada, Australia, and the United States, prevalence of home mechanical ventilation (HMV) ranges from 6.6 to 12.0 per 100,000. Ventilator-assisted individuals (VAIs) living at home are often vulnerable and highly comorbid requiring complex care. In Canada, most care for VAIs is taken-on by their family, leading to poor health-related quality of life (HrQoL) and exceptional caregiver burden. Therefore, supportive interventions for this caregiver population are needed urgently. Peers are a key source of social support, mitigating caregiving-related declines in health and improving HrQoL by decreasing isolation, buffering stress, and increasing self-efficacy. Yet no peer support programs are tailored to VAI caregivers. Due to the financial, geographic, and time limitations, online support delivery may especially meet VAI family caregiver needs. We have developed a peer mentor training and online peer support program for VAI caregivers that includes information-sharing, peer-to-peer communication, and peer mentorship. Objective: Study Stage 1: a) to evaluate face and content validity of the peer mentor training program; and b) to investigate participant satisfaction. Study Stage 2: To evaluate a) feasibility of participant recruitment and online program delivery; b) acceptability, usability, and satisfactoriness; c) experiences of caregivers and peer mentors with the online peer support program; and d) effect of the online peer support program on caregiver health outcomes Methods: Study Stage 1: We will train 7 caregivers to act as peer mentors for the duration of the online peer support program trial. Peer mentors will complete questionnaires rating the utility of individual training sessions and the training program overall. Study Stage 2: We will recruit 30 caregiver peers for a pilot randomized control trial (RCT) of the 12-week online peer support program using a waitlist control. The online peer support program includes private chat, a public discussion forum, and weekly moderated chats. Caregiver peers will complete health outcome questionnaires (i.e. caregiving impact, mastery, coping, personal gain, positive affect, and depression) before and after the peer support program. Upon completion, caregiver peers (intervention arm only) will complete a program evaluation and will be invited to participate in an interview to provide insight into their experience. Peer mentors will be invited to participate in a virtual focus group to provide insight into their experience as mentors. We will judge feasibility based on the number of recruitment and program delivery goals met. We will use Analysis of Covariance (ANCOVA) to compare health outcomes between intervention and control groups. Thematic analysis will be used to analyze interview and focus group data. Results: Peer mentor training was completed with 5 caregivers in July 2018. Conclusions: To-date, two caregivers have beta-tested the website and the online peer support program trial will commence in September 2018. Clinical Trial: NCT03376711
Background: The rapid advancements in healthcare can make it difficult for general physicians and specialists alike to keep their knowledge up to date. In medicine today, there are deficiencies in the...
Background: The rapid advancements in healthcare can make it difficult for general physicians and specialists alike to keep their knowledge up to date. In medicine today, there are deficiencies in the application of knowledge translation in clinical practice. Some medical procedures are not required and therefore no value is added to the patient’s care. These unnecessary medical procedures increase pressures on the healthcare system’s resources, reduce the quality of care, add to the patient’s stress and expose them to other potential risks. In other instances, a prescribed test or a specific treatment that may not be aligned with the evidence is recommended due to its positive outcomes. Knowledge translation tools and better access to medical recommendations can lead to improvements in physicians decision making processes depending on the patient’s specific clinical situation. These tools can provide the physicians with the available options and promote an efficient professional practice. SEKMED is a technological solution providing access to high-quality evidence, based on just-in-time principles, in the application of medical recommendations for clinical decision-making processes recognized by community members, accreditation bodies (Association des médecins d’urgence du Québec or AMUQ, etc.) and standards bodies (Institut national d’excellence en santé et en services sociaux or INESSS, Choosing Wisely, etc.). Objective: The main objective of the pilot project is to assess the validity and usefulness of the SEKMED platform used within a real working clinical practice, specifically the Centre intégré de santé et des services sociaux de l’Outaouais (CISSSO) in Quebec, Canada. To achieve our main objective, 40 emergency physicians from the Hull Hospital and the Gatineau Hospital will participate in the project as well as 20 patient care unit physicians from the Hull Hospital. Additionally, 10 external students or residents studying family medicine from McGill University will also participate in our study. Methods: The project is divided into four phases: 1) scope, 2) data synthesis, 3) develop and validate the recommendations, and 4) implement, monitor and update the recommendations. These phases will enable us to meet our six specific research objectives. The knowledge gained during each phase will be applied on an iterative and continuous basis to all other phases over a period of two years. Results: This project was funded in April 2018 by the Fonds de soutien à l’innovation en santé et en services sociaux (FSISSS) for a period of 24 months. Ethics approval has been attained and the study is expected to begin June 2018 with preliminary results available in December 2018. Both major city hospitals in the Outaouais region, Quebec, Canada have agreed to participate in the project. Conclusions: If results show preliminary efficacy and usability of the system, a large-scale implementation will be conducted.
Background: Promoting Responsible Research and Innovation (RRI) is a major strategy of the “Science with and for Society” work programme of the European Union’s Horizon 2020 Framework Programme...
Background: Promoting Responsible Research and Innovation (RRI) is a major strategy of the “Science with and for Society” work programme of the European Union’s Horizon 2020 Framework Programme for Research and Innovation. RRI aims to achieve a better alignment of research and innovation with the values, needs, and expectations of society. The RRI strategy includes the “keys” of public engagement, open access, gender, ethics, and science education. The STARBIOS2 project promotes RRI in six European research institutions and universities from Bulgaria, Germany, Italy, Slovenia, Poland, and the United Kingdom, working in partnership with a further six institutions from Brazil, Denmark, Italy, South Africa, Sweden, and the United States. Objective: The project has three specific objectives: 1) to attain RRI structural change in six European institutions through the implementation of action plans and to develop action plans for three non-European institutions active in the field of biosciences; 2) to use the implementation of action plans as a learning process with a view to developing a set of guidelines on the implementation of RRI; 3) to develop a sustainable model for RRI in biosciences. Methods: The project consists of inter-related research and implementation designed to achieve the aforementioned specific objectives. The project is organised into six core work packages and five supporting work packages. The core work packages deal with the implementation of institutional action plans in five European institutions based on the structural change activation model. The supporting work packages include technical assistance; learning process on RRI-oriented structural change; monitoring and assessment; communication and dissemination; and project management. Results: The project has received funding from Horizon 2020 and runs for four years from May 2016 to April 2020. As of June 2018, the initial planning phase has been completed. The participating institutions have developed and approved action plans, and commenced their implementation. An observation tool has been launched by the Technical Assistance Team to collect information from the implementation of action plans and the Evaluation & Assessment team has started to monitor the advancement of the project. As part of the communication and dissemination strategy, a project website, a Facebook page, and a Twitter account have been launched and are updated periodically. The International Scientific Advisory Committee has been formed to advise on the reporting and dissemination of the project’s results. Conclusions: In the short term, we anticipate that the project will have a significant impact on the organisational processes and structures improving the uptake of RRI in the participating institutions. In the medium term, we expect to make RRI-oriented organisational change scalable across Europe through the development of guidelines on the implementation of RRI and a model for RRI in the biosciences. In the long term, we expect that the project will help to increase the ability of research institutions to make discoveries and innovations in better alignment with societal needs and values.