Non-randomized Protocols and Methods (ehealth)

HealthData@MAD-R&I: Protocol for Design and Development of a Regional Health Data Infrastructure to Enable Secondary Use of Health Data in Research and Innovation

Montserrat León-García, Sergio Álvarez-Pérez, Janire Gesto-Gómez, Clara Urbano-Molina, Sonia Soto-Díaz, Juan Cárdenas-Valladolid, Luis Rodríguez-Rodríguez, Antonio Díaz-Holgado, Isabel del Cura-González, Javier De La Cruz-Bertolo, Noelia García-Barrio, Juan Luis Cruz-Bermúdez, Cristina García-Fernández, Carlos Rodríguez-Antolín, Laila García-Aldars, Elsa María Moreda-Sánchez, Álvaro Roldán López, José María Veganzones Alonso-Cortés, Ana Isabel Gonzalez Gonzalez, Miguel A Salinero-Fort, HealthData@MAD-R&I Working Group

JMIR Res Protoc 2026 (Mar 20); 15:e82815

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A Digital Intervention for Capturing Real-Time Health Data for Epilepsy Seizure Forecasting: Protocol for the ATMOSPHERE Study

Lauren Thompson, Emily Nielsen, Emily E V Quilter, Amelia Slay, Marceli Wac, Matthew Wragg, Samuel Downes, Phil Tittensor, Leandro Junges, Liz Stuart, Rosie Charles, Peter Kissack, Yasser Qureshi, Amberly Brigden

JMIR Res Protoc 2026 (Mar 20); 15:e85993

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Utilization and Feasibility of a Wearable Device in Patients With Sedative Effects of Drugs: Protocol for a Prospective Observational Study for the Advanced Respiratory Monitoring Events in Drug Toxicity (ARM-ED) Study

Lisa Christine Dunlop, Bruce Henderson, Osian Meredith, Chris Trueman, Christopher Carlin, Robert Docking, David J Lowe

JMIR Res Protoc 2026 (Mar 19); 15:e66961

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The Development and Protocol for Testing a Co-Created Digital Intervention (Sentinel) to Improve Mental Well-Being and Help Manage and Prevent Trauma in First Responders

Nicola Cogan, Alison Kirk, Christoph Graf

JMIR Res Protoc 2026 (Mar 18); 15:e72250

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Digital Dissemination Strategies for Health Promotion Videos in Indigenous Communities in California: Protocol for a Three-Arm Comparative Study

Lucía Abascal Miguel, Anna E Epperson, Alison B Comfort, Darío León, Mary E Garcia, Alicia R Riley, Nadia Diamond-Smith

JMIR Res Protoc 2026 (Mar 17); 15:e84674

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Real-Time Type 1 Diabetes Self-Management Decision-Making in Adolescents: Protocol for a Longitudinal Mixed Methods Study Using Text Messaging and Continuous Glucose Monitoring

Melissa DeJonckheere, Samantha A Chuisano, Juniar Lucien, Fouzaan Amjad, Oorvi Duvvuri, Hasan Khan, Maryam Khan, Rafee Mirza, Maya Joy Ollivierre, Timothy Guetterman, Yu Kuei Lin, Lorraine R Buis, James E Aikens, Caroline Richardson, Joyce M Lee

JMIR Res Protoc 2026 (Mar 04); 15:e83218

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Digitally Enhanced Routine Outcome Monitoring in Italian Psychotherapy: Protocol for a Longitudinal Implementation Study

Mattia Vincenzo Olive, Antonino La Tona, Vivian Ostwald, Agostino Brugnera, Gianluca Lo Coco, Angelo Compare, Dana Tzur Bitan, Cristina Masella

JMIR Res Protoc 2026 (Mar 02); 15:e82837

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AI Models to Reduce Surgical Complications Through Intraoperative Video Analysis: Protocol for a Prospective Cohort Study

António Sampaio Soares, Sophia Bano, Laura T Castro, Margarida Pascoal, Ricardo Rocha, Paulo Alves, Paulo Mira, Joao Costa, Manish Chand, Danail Stoyanov, Catarina Barata

JMIR Res Protoc 2026 (Feb 26); 15:e62734

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Acoustic Emission Biomarkers for the Detection and Monitoring of Early Knee Osteoarthritis: Protocol for a Prospective, Single-Center, Exploratory Study

Louis Leuthard, Jérôme Thevenot, Tomás Teijeiro, David Atienza, Vincent A Stadelmann

JMIR Res Protoc 2026 (Feb 26); 15:e67032

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The Effect of the DemensiaKITA Mobile Health App Intervention on Knowledge, Attitude, Practice, and Burden Level of Dementia Caregivers in Kuala Lumpur and Selangor, Malaysia: Protocol for a Nonrandomized Controlled Trial

Nurulizzah Mahfar, Nik Nairan Abdullah, Dalila Roslan, Khalid Ibrahim, Ungku Ahmad Ameen Ungku Mohd Zam, Noraliza Noordin Merican, Xin Wee Chen, Mariam Mohamad

JMIR Res Protoc 2026 (Feb 25); 15:e83699

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Surgical Outcome of Iris Claw and Scleral Tuck Intraocular Lens in Primary Cataract Surgery by Phacoemulsification in a Tertiary Care Center: Protocol for a Randomized Controlled Trial

Mohammed Kaderi, Sachin Daigavane

JMIR Res Protoc 2026 (Feb 23); 15:e80943

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Toward Best Practice Guidelines and Curricula for Virtual Care (Telehealth) in a Cancer Center: Protocol for a Multimethod Study

Sharon Brownie, Lauren Parkinson-Zarb, Andrew Dimech, Maria Ftanou, Patrick Broman

JMIR Res Protoc 2026 (Feb 20); 15:e81768

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Evaluation of Reduced Single-Photon Emission Computed Tomography Imaging Protocols and Software Variability in 177Lu-DOTATATE Dosimetry: Protocol for an Exploratory Observational Trial

Takayuki Yagihashi, Kenta Miwa, Noriaki Miyaji, Satoru Sugimoto, Hideki Hayakawa, Noritoshi Kobayashi, Shoko Takano, Taro Murai

JMIR Res Protoc 2026 (Feb 19); 15:e83248

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Effectiveness of a Digital Awareness App in HIV/AIDS Mitigation Among Transgender Individuals in Rawalpindi District: Protocol for a Quasi-Experimental Study

Muhammad Mudassar Farooq, Shaheer Ellahi Khan, Ali Ahmed

JMIR Res Protoc 2026 (Feb 18); 15:e84610

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Contribution of Emotion Dynamics to Adolescent Psychosocial Well-Being: Protocol for a Longitudinal Study

Carli Mastronardi, Jade Powers, Rosanne Menna, Lance M Rappaport

JMIR Res Protoc 2026 (Feb 18); 15:e76333

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Exploring the Cognitive and Behavioral Risks and Maintenance Factors of Hikikomori: Protocol for an Ecological Momentary Assessment Study

Alexander MacLellan, Keisuke Takano

JMIR Res Protoc 2026 (Feb 17); 15:e81384

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Evaluating Electroencephalogram-Based Predictive Model for Drowsiness Measurement to Reduce Accident Risk in Active Individuals: Protocol for a Preliminary Monocentric Study

Chloé Boitard, Zoé Mazurie, Khadijeh Sadatnejad, Julien Coelho, Patricia Sagaspe, Julie Lenoir, Julien Mattei, Pierre Berthomier, Marie Brandewinder, Pierre Philip, Jean-Arthur Micoulaud Franchi, Christian Berthomier, Jacques Taillard

JMIR Res Protoc 2026 (Feb 17); 15:e83969

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Using Smartphone-Based Digital Phenotyping to Predict Relapse in Serious Mental Disorders Among Slum Residents in Dhaka, Bangladesh: Protocol for a Machine Learning Study

Nadia Alam, Chayon Kumar Das, Neelabja Roy, Domenico Giacco, Swaran P Singh, Sagar Jilka

JMIR Res Protoc 2026 (Feb 04); 15:e79826

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Development and Feasibility Assessment of an Intrinsic Capacity Program in Primary Care: Protocol for an Implementation Science Approach

Qing Wang, Mimaika Luluina Ginting, Ezra Ho, Siew Fong Goh, Jonathan Gao, Woan Shin Tan, Yew Yoong Ding, Wei Liang David Ng, Jonathan Choon Aik Ng, Sing Cheer Kwek, Richard Jor Yeong Hui, Zhen Sinead Wang, Chirk Jenn Ng, Grace Sum, The IMPACTFrail Group

JMIR Res Protoc 2026 (Feb 02); 15:e84257

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Development of an Ethico-Legal Framework for Quality Improvement and Performance Management in Health Care: Protocol for a Qualitative Study

Kavisha Shah, Anna Janssen, Cameron Stewart, Tim Shaw, Ian Kerridge

JMIR Res Protoc 2026 (Jan 30); 15:e82167

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