RCTs - Protocols/Proposals (eHealth)

Cognitive Behavioral Immersion for Depression: Protocol for a Three-Arm Randomized Controlled Trial of Peer-Based Coaching in the Metaverse

Noah Robinson, Francisco N Ramos, Steven D Hollon, Gloria T Han, Iony D Ezawa

JMIR Res Protoc 2025 (May 06); 14:e65970

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Enhancing Adherence to Continuous Positive Airway Pressure Therapy in Patients With Obstructive Sleep Apnea Using Augmented Reality: Protocol for a Randomized Controlled Trial

Ming-Che Chen, Yen-Chin Chen, Cheng-Yu Lin

JMIR Res Protoc 2025 (May 06); 14:e69757

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Short, Animated Storytelling Video to Reduce Addiction Stigma in 13,500 Participants Across Multiple Countries Through an Online Approach: Protocol for a Randomized Controlled Trial

Maya Adam, Maxwell Klapow, Merlin Greuel, Misha Seeff, Julia K Rohr, Andrew Gordon, Doron Amsalem, Till Bärnighausen

JMIR Res Protoc 2025 (May 05); 14:e73382

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An In-Person and Online Intervention for Parkinson Disease (UPGRADE-PD): Protocol for a Patient-Centered and Culturally Tailored 3-Arm Crossover Trial

Michail Elpidoforou, Irene Grimani, Marianna Papadopoulou, Nikolaos Papagiannakis, Anastasia Bougea, Athina-Maria Simitsi, Evangelos Sfikas, Ioanna Alexandratou, Ioanna Alefanti, Roubina Antonelou, Christos Koros, Ioanna Mavroyianni, Chrysa Chrysovitsanou, Leonidas Stefanis, Daphne Bakalidou

JMIR Res Protoc 2025 (May 02); 14:e65490

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Improving Diet Quality of People Living With Obesity by Building Effective Dietetic Service Delivery Using Technology in a Primary Health Care Setting: Protocol for a Randomized Controlled Trial

Deborah A Kerr, Clare E Collins, Andrea Begley, Barbara Mullan, Satvinder S Dhaliwal, Claire E Pulker, Fengqing Zhu, Marie Fialkowski, Richard L Prince, Richard Norman, Anthony P James, Paul Aveyard, Helen Mitchell, Jacquie Garton-Smith, Megan E Rollo, Chloe Maxwell-Smith, Amira Hassan, Hayley Breare, Lucy M Butcher, Christina M Pollard

JMIR Res Protoc 2025 (Apr 30); 14:e64735

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Mobile Health–Based Motivational Interviewing to Promote SARS-CoV-2 Vaccination in Rural Adults: Protocol for a Pilot Randomized Controlled Trial

Ashlea Braun, Sarah Corcoran, Khue Tu Doan, Cameron Jernigan, Cate Moriasi, Michael Businelle, Thanh Bui

JMIR Res Protoc 2025 (Apr 28); 14:e64010

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Feasibility of Using Resting Heart Rate and Step Counts From Patient-Held Sensors During Clinical Assessment of Medical Emergencies (FUSE): Protocol for Prospective Observational Study in European Hospitals

Jack Barrington, Christian Subbe, John Kellett, Erika Frischknecht Christensen, Mikkel Brabrand, Prabath Nanayakkara, Jelmer Alsma

JMIR Res Protoc 2025 (Apr 28); 14:e55975

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Efficacy And Safety of Acupoint Catgut Embedding for Perennial Allergic Rhinitis: Protocol for a Randomized Clinical Trial

Zijie Cai, ChunXue Meng, Fei Wang, ChunZhi Tang, Jing Zhang, Qian Zhang, Bin Guo

JMIR Res Protoc 2025 (Apr 21); 14:e63933

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The Effectiveness of a Race-Based Stress Reduction Intervention on Improving Stress-Related Symptoms and Inflammation in African American Women at Risk for Cardiometabolic Disease: Protocol for Recruitment and Intervention for a Randomized Controlled Trial

Karen L Saban, Cara Joyce, Alexandria Nyembwe, Linda Janusek, Dina Tell, Paula de la Pena, Darnell Motley, Lamise Shawahin, Laura Prescott, Stephanie Potts-Thompson, Jacquelyn Y Taylor

JMIR Res Protoc 2025 (Apr 18); 14:e65649

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Interactive Computer-Adaptive Chronic Kidney Disease (I-C-CKD) Education for Hospitalized African American Patients: Protocol for a Randomized Controlled Trial

Akilah King, Tayo Omoniyi, Lindsay Zasadzinski, Cynthia Gaspard, Denesha Gorman, Milda Saunders

JMIR Res Protoc 2025 (Apr 17); 14:e66846

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Text Message Intervention to Facilitate Secure Storage and Disposal of Prescription Opioids to Prevent Diversion and Misuse: Protocol for a Randomized Controlled Trial

Kathleen L Egan, Melissa J Cox, Donald W Helme, J Todd Jackson, Alice R Richman

JMIR Res Protoc 2025 (Apr 17); 14:e60332

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Testing a Machine Learning–Based Adaptive Motivational System for Socioeconomically Disadvantaged Smokers (Adapt2Quit): Protocol for a Randomized Controlled Trial

Ariana Kamberi, Benjamin Weitz, Julie Flahive, Julianna Eve, Reem Najjar, Tara Liaghat, Daniel Ford, Peter Lindenauer, Sharina Person, Thomas K Houston, Megan E Gauvey-Kern, Jackie Lobien, Rajani S Sadasivam

JMIR Res Protoc 2025 (Apr 16); 14:e63693

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Assessing the Noninferiority of a Rhythm and Language Training Serious Game Combined With Speech Therapy Versus Speech Therapy Care for Children With Dyslexia: Protocol for an Investigator-Blinded Randomized Controlled Trial

Charline Grossard, Mélanie Descamps, Sara Cadoni, Hugues Pellerin, François Vonthron, Jean Xavier, Bruno Falissard, David Cohen

JMIR Res Protoc 2025 (Apr 03); 14:e71326

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Cooperative Virtual Reality Gaming for Anxiety and Pain Reduction in Pediatric Patients and Their Caregivers During Painful Medical Procedures: Protocol for a Randomized Controlled Trial

Stefan Liszio, Franziska Bäuerlein, Jens Hildebrand, Carolin van Nahl, Maic Masuch, Oliver Basu

JMIR Res Protoc 2025 (Mar 31); 14:e63098

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Ayurveda Management of Menorrhagia (Raktapradara): Protocol for a Randomized Controlled Trial

Shivshankar Rajput, Shweta Mata, Upma Saxena, Sarada Ota, Bharti Gupta

JMIR Res Protoc 2025 (Mar 31); 14:e60801

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Efficacy of a Web-Based Integrated Growth Mindset Intervention on Reducing Anxiety Among Social Work and Counseling Practicum Trainees: Protocol for a 2-Arm Randomized Controlled Trial

Yongyi Wang, An Xi, Stella S K Wong, Kong Yam, Janet Tsin Yee Leung, Shimin Zhu

JMIR Res Protoc 2025 (Mar 27); 14:e67234

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Treatment of Substance Use Disorders With a Mobile Phone App Within Rural Collaborative Care Management (Senyo Health): Protocol for a Mixed Methods Randomized Controlled Trial

Tyler S Oesterle, Nicholas L Bormann, Margaret M Paul, Scott A Breitinger, Benjamin Lai, Jamie L Smith, Cindy J Stoppel, Stephan Arndt, Mark D Williams

JMIR Res Protoc 2025 (Mar 26); 14:e65693

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Feasibility, Acceptability, and Potential Effects of a Digital Oral Anticancer Agent Intervention: Protocol for a Pilot Randomized Controlled Trial

Saima Ahmed, Christine Maheu, Walter Gotlieb, Gerald Batist, Carmen G Loiselle

JMIR Res Protoc 2025 (Mar 26); 14:e55475

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Predicting Therapy Outcomes in Patients With Stress-Related Disorders: Protocol for a Predictive Modeling Study

Ludwig Franke Föyen, Victoria Sennerstam, Evelina Kontio, Oskar Flygare, Magnus Boman, Elin Lindsäter

JMIR Res Protoc 2025 (Mar 25); 14:e65790

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Examining the Efficacy of the Telehealth Assessment and Skill-Building Kit (TASK III) Intervention for Stroke Caregivers: Protocol for a Randomized Controlled Clinical Trial

Tamilyn Bakas, Elaine Miller, Heidi Sucharew, Natalie Kreitzer, Jahmeel Israel, Matthew Rota, Brett Harnett, Kari Dunning, Holly Jones, Michael McCarthy, Bonnie Brehm, Joan K Austin, Pamela H Mitchell

JMIR Res Protoc 2025 (Mar 25); 14:e67219

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