RCTs - Protocols/Proposals (eHealth)

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Articles published in 2026 in this theme: 90 (scroll down to load remaining articles)

2026

Couple reviewing health data on a smartphone app

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Family-Supported mHealth Coaching for Middle-Aged Men With Chronic Liver Disease and Metabolic Risk Factors: Protocol for a Pilot Randomized Controlled Trial

Seoeun Bae, Seojin Lee, Yeonsoo Jang

JMIR Res Protoc 2026 (Oct 30); 15:e95490

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Woman on video call for remote work productivity tips in home office

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Feasibility and Acceptability of Videoconference-Based Family Psychoeducation for Young Adult Caregivers of Family Members With Major Depressive Disorder: Protocol for a Pilot Randomized Controlled Trial

Hideki Nakamura, Sho Okawa, Hiroki Tanoue, Yoshihiro Goto, Akari Matsuzawa, Keiko Ito

JMIR Res Protoc 2026 (Oct 23); 15:e105182

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Man breaks cigarette and gives thumbs up, symbolizing quitting smoking.

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School-Family Linked and Online-Offline Combined Tobacco Control Intervention for Adolescents: Protocol for a Cluster Randomized Pilot Trial

Wanqi Liu, Qi Su, Yuan Cao, Fengyi Huang, Chuning Luo, Xinying Zeng, Ying Liu, Gang Yang, Jinsa Zhou, Meifeng Zhang, Fen Liu, Shiwei Liu

JMIR Res Protoc 2026 (Oct 21); 15:e86503

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Doctor shows tablet with "Vital-MD Study" to elderly patient

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Clinical Effectiveness of AI-Based Cardiac Arrest Prediction System for General Ward Patients (VITAL-MD): Protocol for a Multicenter Pragmatic Stepped Wedge Cluster Randomized Controlled Trial

Mincheol Kim, Kyung Hoon Kim, Minsoo Kim, Sun Jung Kwon, Myung Soo Park, Ah Jin Kim, Man-Jong Lee, Mi Hwa Park, Hyung Keun Cha, Minhyeok Lee, In Beom Jeong, Soon Joo Wang, Sung Bak An, Jeen Hwa Lee, Kyung-Jae Cho, Jinhui Jang, HyoJin Jeong, Yoon Young Lee, Woori Han, Jung Soo Kim, Dongjoon Yoo, VITAL-MD Study Group

JMIR Res Protoc 2026 (Oct 19); 15:e104230

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Man smiling while on a spin bike during a virtual fitness class on laptop

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Feasibility of High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumor and Young Adults With Isocitrate Dehydrogenase–Mutant Gliomas (HYPE): Protocol for a Randomized Controlled Trial

Elizabeth Cox, Meghan Tahbaz, Ellaney Matarese, Rebekah L Wilson, L Nicolas Gonzalez Castro, Hajime Uno, Tabitha Cooney, Jordan Lane, Mary K Norris, Kira Bona, Rahela Aziz-Bose, Christina M Dieli-Conwright

JMIR Res Protoc 2026 (Oct 15); 15:e88718

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Hands holding phone photographing avocado toast with egg and tea

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Reminder Strategies to Improve Meal-Logging Adherence: Protocol for a Microrandomized Trial

Magdalena Fuchs, Victoria Brügger, Qiuhan Jin, Benjamin Wirth, Stefan Bilz, Florian von Wangenheim, Michael Brändle, Tobias Kowatsch, Mia Jovanova

JMIR Res Protoc 2026 (Oct 05); 15:e100239

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Woman with short blonde hair smiling while looking at her pink smartphone

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Cocreation of a Digital Psychological Intervention to Improve Mental Health Among Survivors of Breast Cancer (SerenApp): Protocol for a Usability and Pilot Randomized Controlled Trial

Irene Zarcos-Pedrinaci, Vanesa Ramos-García, María Padilla-Ruíz, Francisco Rivas-Ruíz, Antoni Baena, Santiago Galán, Andrea Duarte-Díaz, Lilisbeth Perestelo-Pérez, Yolanda Álvarez Pérez, Cristina Valcárcel-Nazco, Maximino Redondo Bautista, Esperanza Varela-Moreno

JMIR Res Protoc 2026 (Sep 30); 15:e87151

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Woman uses phone app tracking energy, sleep, and activity.

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Evaluation of a Mental Health Care App–Based Fatigue Management Program for Patients With Inflammatory Bowel Disease in Remission: Protocol for a Randomized Controlled Trial

Makoto Tanaka, Sayaka Wakai, Kayoko Sakagami, Aki Kawakami, Hikari N Takashina, Jeongae Kang, Masakazu Nagahori, Hiroaki Ito

JMIR Res Protoc 2026 (Sep 28); 15:e96593

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DIPAR Digital Diabetes Patient Reminder Tool on a smartphone screen

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The Digital Diabetes Patient Reminder Tool for Adults With Type 2 Diabetes: Protocol for a Proof-of-Concept Randomized Controlled Trial

Barbara Annancy, Steve Van den Bulck, Steffen Fieuws, Laura Van den Mooter, Roman Vangoitsenhoven, Geert Goderis

JMIR Res Protoc 2026 (Sep 22); 15:e93006

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Woman using a smartphone with a colorful app interface showing "Help" and "Thinking" sections.

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A Culturally Adapted Smoking Cessation App (IndigeQuit) for American Indian and Alaska Native Adults: Protocol for a Randomized Clinical Trial

Jonathan B Bricker, Margarita Santiago-Torres, Brianna M Sullivan, Kristin E Mull, Hershel W Clark, Chase Kornacki, Trivia Afraid of Lightning-Craddock, Dean S Seneca, Crystal M Stanford, Sierra L Wilcox, Patricia Nez Henderson, Lonnie Nelson

JMIR Res Protoc 2026 (Sep 02); 15:e102675

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Two women in a living room, one wearing a VR headset and gesturing, the other watching

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One-Session Versus Three-Sessions of Virtual Reality Exposure Therapy for Public Speaking Anxiety: Protocol of a Randomized Controlled Trial

Goda Gegieckaitė, Olga Zamalijeva, Karolina Petraškaitė, Egle Nagevice, Philip Lindner, Per Carlbring, Tom Van Daele, Gerhard Andersson, Jonas Eimontas

JMIR Res Protoc 2026 (Aug 25); 15:e89612

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Patient stands on pressure plate for gait analysis while technician monitors computer.

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Efficacy of Mulligan Mobilization, Maitland Mobilization, High-Velocity Thrust, and Muscle Energy Technique for Pain, Disability, and Center-of-Gravity Displacement in Patients With Sacroiliac Joint Dysfunction: Protocol for a Randomized Controlled Trial

Neha Chitale, Lajwanti Lalwani

JMIR Res Protoc 2026 (Aug 21); 15:e87715

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Elderly woman in hospital bed with oxygen mask and beanie

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Effect of Remote Vital Signs Monitoring in People Receiving Long-Term Oxygen Therapy: Protocol for a Randomized Controlled Trial

Elinny Raissa Moreira dos Reis, Gabriela Martins Alencar, Amanda Maria Schneider, Mari Claussen Tani Fernandes, Juliana de Melo Batista dos Santos, Celso Ricardo Fernandes Carvalho

JMIR Res Protoc 2026 (Aug 21); 15:e93352

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Man in a mask on a stationary bike during a cardiopulmonary exercise test.

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The Effects of AI-Guided Exercise and a Smart Ring on Arterial Stiffness: Protocol for a Randomized Controlled Trial

Heikki Pentikäinen, Sofia Strömmer, Drake Caraker, Julia Kosonen, Aleksi Rantanen, Saila Hiltunen, Pirjo Komulainen, Heidi Similä, Massimiliano de Zambotti, Kai Savonen, Pauli Ohukainen

JMIR Res Protoc 2026 (Aug 21); 15:e98213

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Father checks young son's back for rash or irritation, indoors.

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Remote Interdisciplinary Care for Atopic Dermatitis Using a Digital Care Concept (ADCompanion): Protocol for a Multicenter Randomized Trial

Stephanie Dramburg, Camilo José Hernandez Toro, Josephine Telschow, Susanne Abraham, Meslina Almaci, Anna Behringer, Simone Christel, Angela Cornelius, Janina Feustel, Sascha Fischer, Isabelle Gloeyer, Nadia Günther, Katharina Hagemeister, Eckard Hamelmann, Leonard Harries, Annice Heratizadeh, Nora Knappe, Sonja Lämmel, Eva Moennig, Irena Neustädter, Christina Pham, Laura Rechtien, Thomas Reinhold, Christina Schnopp, Christina Schorlemer, Lukas Sollfrank, Sophie Spies, Kristina Stamos, Michael Sticherling, Piera Tierno, Marion Trentmann, Marie-Therese Unterweger, Christian Vogelberg, Hanna Winkler, Margitta Worm, Mehrak Yoosefi, Ulrike Grittner

JMIR Res Protoc 2026 (Aug 20); 15:e88025

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Elderly man with hand on chest, discussing health concerns with a doctor

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Protocol for a Sequential Multiple Assignment Randomized Trial to Improve Physical Activity and Diet Quality in Survivors of Cancer

Eric J Chow, Ethan D Lee, Marie Hershberger, Kari Jenssen, Chongzhi Di, David R Doody, Bridget Hogue, Jason A Mendoza, Tammy M Muller, Jeannette M Schenk, Karen L Syrjala, Yueqi Xu, Jean Yi, Ying-Qi Zhao, Gregory T Armstrong, Marian L Neuhouser, Kevin C Oeffinger

JMIR Res Protoc 2026 (Aug 13); 15:e104572

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Diners enjoy Hong Kong-style cafe cuisine at a bustling cha chaan teng.

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Therapist-Facilitated Virtual Reality Intervention for Social Anxiety Among Youth: Protocol for a Randomized Controlled Trial

Yi Zhou Wang, Ming Tak Hue, Kung Wong Lau, De Hui Zhou, Siu Man Ng, Xue Weng

JMIR Res Protoc 2026 (Aug 11); 15:e86937

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Boy playing a racing game on a touch screen table with colorful controllers.

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HABIT-ILE@home for Children With Bilateral Cerebral Palsy: Protocol for Noninferiority and Superiority Randomized Controlled Trials

Zélie Rosselli, Merlin Somville, Edouard Ducoffre, Carlyne Arnould, Yannick Bleyenheuft, Geoffroy Saussez

JMIR Res Protoc 2026 (Aug 11); 15:e89872

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Young woman looking stressed while reading on her phone on a sofa

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Effectiveness and Cost-Effectiveness of the Tankevirus and Grubl Mental Health Apps Compared With a Placebo App—Mental Health Intervention With Digital Applications (MIND-APP): Protocol for a Randomized Controlled Researcher-Blinded Trial

Kim Rand, Julia Menichetti, Torbjørn Wisløff, Hanne Helene Brorson

JMIR Res Protoc 2026 (Aug 10); 15:e84096

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Woman in headscarf on telehealth call with doctor on laptop

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Graded Exercise Therapy and Cognitive Behavioral Therapy for Fatigue in Patients With Breast Cancer: Protocol for a Randomized Controlled Pilot Study

Joanna Rui En Fong, Pei Ling Tan, Michelle Tian Nee Chow, Whee Sze Ong, Irene Teo, Ryan Shea Ying Cong Tan, Mothi Babu Ramalingam

JMIR Res Protoc 2026 (Aug 07); 15:e91330

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