<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="letter"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Res Protoc</journal-id><journal-id journal-id-type="publisher-id">ResProt</journal-id><journal-id journal-id-type="index">5</journal-id><journal-title>JMIR Research Protocols</journal-title><abbrev-journal-title>JMIR Res Protoc</abbrev-journal-title><issn pub-type="epub">1929-0748</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v15i1e113321</article-id><article-id pub-id-type="doi">10.2196/113321</article-id><article-categories><subj-group subj-group-type="heading"><subject>Letter to the Editor</subject></subj-group></article-categories><title-group><article-title>Authors&#x2019; Reply: Accelerometer-Based Step Counts May Be Confounded by Repetitive Motor Behaviors in Adults With Autism Spectrum Disorder</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" equal-contrib="yes"><name name-style="western"><surname>Nunez-Gaunaurd</surname><given-names>Annabel</given-names></name><degrees>PT, PhD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Tovin</surname><given-names>Melissa M</given-names></name><degrees>PT, PhD</degrees><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Hale</surname><given-names>Melissa</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Li</surname><given-names>Tan</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Bhat</surname><given-names>Anjana</given-names></name><degrees>PT, PhD</degrees><xref ref-type="aff" rid="aff5">5</xref></contrib></contrib-group><aff id="aff1"><institution>Department of Physical Therapy, Nicole Wertheim College of Nursing &#x0026; Health Sciences, Florida International University</institution><addr-line>11200 SW 8th St, AHC3-424</addr-line><addr-line>Miami</addr-line><addr-line>FL</addr-line><country>United States</country></aff><aff id="aff2"><institution>Department of Physical Therapy, Miller School of Medicine, University of Miami</institution><addr-line>Coral Gables</addr-line><addr-line>FL</addr-line><country>United States</country></aff><aff id="aff3"><institution>Child and Family Services, College of Arts and Sciences, University of Miami</institution><addr-line>Coral Gables</addr-line><addr-line>FL</addr-line><country>United States</country></aff><aff id="aff4"><institution>Biostatistics, Robert Stempel College of Public Health and Social Work, Florida International University</institution><addr-line>Miami</addr-line><addr-line>FL</addr-line><country>United States</country></aff><aff id="aff5"><institution>Department of Physical Therapy, College of Health Sciences, University of Delaware</institution><addr-line>Newark</addr-line><addr-line>DE</addr-line><country>United States</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Nedunchezhiyan</surname><given-names>Surya</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Annabel Nunez-Gaunaurd, PT, PhD, Department of Physical Therapy, Nicole Wertheim College of Nursing &#x0026; Health Sciences, Florida International University, 11200 SW 8th St, AHC3-424, Miami, FL, 33199, United States, 1 305-348-2265; <email>annnunez@fiu.edu</email></corresp><fn fn-type="equal" id="equal-contrib1"><label>*</label><p>these authors contributed equally</p></fn></author-notes><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>30</day><month>10</month><year>2026</year></pub-date><volume>15</volume><elocation-id>e113321</elocation-id><history><date date-type="received"><day>30</day><month>09</month><year>2026</year></date><date date-type="rev-recd"><day>08</day><month>10</month><year>2026</year></date><date date-type="accepted"><day>09</day><month>10</month><year>2026</year></date></history><copyright-statement>&#x00A9; Annabel Nunez-Gaunaurd, Melissa M Tovin, Melissa Hale, Tan Li, Anjana Bhat. Originally published in JMIR Research Protocols (<ext-link ext-link-type="uri" xlink:href="https://www.researchprotocols.org">https://www.researchprotocols.org</ext-link>), 30.10.2026. </copyright-statement><copyright-year>2026</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://www.researchprotocols.org">https://www.researchprotocols.org</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://www.researchprotocols.org/2026/1/e113321"/><related-article related-article-type="commentary article" ext-link-type="doi" xlink:href="10.2196/86020" xlink:title="Comment on" xlink:type="simple">https://www.researchprotocols.org/2026/1/e86020</related-article><related-article related-article-type="commentary article" ext-link-type="doi" xlink:href="10.2196/110988" xlink:title="Comment on" xlink:type="simple">https://www.researchprotocols.org/2026/1/e110988</related-article><kwd-group><kwd>autism spectrum disorder</kwd><kwd>physical activity</kwd><kwd>co-participation</kwd><kwd>family support</kwd><kwd>autism in adulthood</kwd><kwd>telehealth</kwd><kwd>wearable devices</kwd><kwd>physical function</kwd><kwd>remote assessment</kwd><kwd>health disparities</kwd><kwd>minority health</kwd><kwd>adult autism</kwd><kwd>protocol study</kwd><kwd>cross-sectional design</kwd><kwd>patient-reported outcomes</kwd><kwd>motor impairments</kwd><kwd>rehabilitation</kwd><kwd>digital health</kwd></kwd-group></article-meta></front><body><p>We thank the authors of the letter to the editor [<xref ref-type="bibr" rid="ref1">1</xref>] for their thoughtful comments regarding our protocol paper, &#x201C;Remote Assessment of Physical Function and Physical Activity in Adults With Autism Spectrum Disorder: Protocol for Feasibility, Validity, and Reliability Study&#x201D; [<xref ref-type="bibr" rid="ref2">2</xref>]. We appreciate their interest in the methodological considerations surrounding accelerometer-derived step counts in adults with autism spectrum disorder (ASD).</p><p>The authors raise an important concern regarding the potential influence of repetitive motor behaviors, including stereotypic movements such as hand flapping, rocking, and pacing, on accelerometer-based step count estimates. We agree that consumer-grade wearable devices are primarily developed and validated in neurotypical populations and that movement characteristics unique to individuals with ASD may affect measurement accuracy [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>]. In particular, wrist-worn accelerometers may not consistently distinguish ambulatory activity from certain repetitive movements, potentially leading to overestimation of step counts in some cases. However, the extent to which repetitive motor behaviors influence Fitbit-derived step counts in adults with ASD remains largely unknown. To our knowledge, there is limited evidence regarding the validity of Fitbit-derived step counts in adults with ASD, particularly among individuals who exhibit prominent repetitive motor behaviors. While prior studies have successfully used Fitbit devices to monitor physical activity and evaluate physical activity interventions in adults with ASD, these studies were not designed to establish the criterion validity of step-count measurements in this population [<xref ref-type="bibr" rid="ref5">5</xref>].</p><p>The purpose of our study was to examine the construct validity and test-retest reliability of remotely administered physical function assessments in adults with ASD. Consistent with our analytic framework, Fitbit-derived step counts were included as one of several indicators of physical activity and functioning, alongside measures of lower-extremity function, fall risk, and comorbidity burden, to evaluate the construct validity of patient-reported physical function. Fitbit step counts were not intended to serve as a criterion standard for physical function assessment.</p><p>We agree that future studies comparing Fitbit-derived step counts with criterion measures such as direct observation, video-coded step counts, or research-grade accelerometry in adults with ASD would be valuable. Research-grade devices that provide access to raw acceleration signals may allow investigators to better distinguish ambulatory activity from stereotypic movements. However, these measures involve greater cost, analytic complexity, and participant burden. Consumer wearables such as Fitbit devices remain a viable option for large-scale and remote studies because they provide a practical, scalable, and objective estimate of physical activity. Establishing their validity and limitations in adults with ASD is therefore an important area for future research. However, such validation was beyond the scope of the current pilot study and protocol.</p><p>We appreciate the authors for highlighting this important issue. Continued research on the validity of wearable activity-monitoring technologies in adults with ASD will help strengthen the interpretation and application of physical activity metrics in both research and clinical practice.</p></body><back><notes><sec><title>Funding</title><p>The authors declared no financial support was received for this work.</p></sec></notes><fn-group><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">ASD</term><def><p>autism spectrum disorder</p></def></def-item></def-list></glossary><ref-list><title>REFERENCES:</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Malik</surname><given-names>MA</given-names> </name><name name-style="western"><surname>Fatima</surname><given-names>T</given-names> </name></person-group><article-title>Accelerometer-based step counts may be confounded by repetitive motor behaviors in adults with autism spectrum disorder</article-title><source>JMIR Res Protoc</source><year>2026</year><volume>1</volume><fpage>e110988</fpage><pub-id pub-id-type="doi">10.2196/110988</pub-id></nlm-citation></ref><ref id="ref2"><label>2</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Nunez-Gaunaurd</surname><given-names>A</given-names> </name><name name-style="western"><surname>Tovin</surname><given-names>MM</given-names> </name><name name-style="western"><surname>Hale</surname><given-names>M</given-names> </name><name name-style="western"><surname>Li</surname><given-names>T</given-names> </name><name name-style="western"><surname>Bhat</surname><given-names>A</given-names> </name></person-group><article-title>Remote assessment of physical function and physical activity in adults with autism spectrum disorder: protocol for feasibility, validity, and reliability study</article-title><source>JMIR Res Protoc</source><year>2026</year><month>08</month><day>31</day><volume>15</volume><fpage>e86020</fpage><pub-id pub-id-type="doi">10.2196/86020</pub-id><pub-id pub-id-type="medline">42673582</pub-id></nlm-citation></ref><ref id="ref3"><label>3</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Toth</surname><given-names>LP</given-names> </name><name name-style="western"><surname>Park</surname><given-names>S</given-names> </name><name name-style="western"><surname>Springer</surname><given-names>CM</given-names> </name><name name-style="western"><surname>Feyerabend</surname><given-names>MD</given-names> </name><name name-style="western"><surname>Steeves</surname><given-names>JA</given-names> </name><name name-style="western"><surname>Bassett</surname><given-names>DR</given-names> </name></person-group><article-title>Video-recorded validation of wearable step counters under free-living conditions</article-title><source>Med Sci Sports Exerc</source><year>2018</year><month>06</month><volume>50</volume><issue>6</issue><fpage>1315</fpage><lpage>1322</lpage><pub-id pub-id-type="doi">10.1249/MSS.0000000000001569</pub-id><pub-id pub-id-type="medline">29381649</pub-id></nlm-citation></ref><ref id="ref4"><label>4</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Melo</surname><given-names>C</given-names> </name><name name-style="western"><surname>Ruano</surname><given-names>L</given-names> </name><name name-style="western"><surname>Jorge</surname><given-names>J</given-names> </name><etal/></person-group><article-title>Prevalence and determinants of motor stereotypies in autism spectrum disorder: a systematic review and meta-analysis</article-title><source>Autism</source><year>2020</year><month>04</month><volume>24</volume><issue>3</issue><fpage>569</fpage><lpage>590</lpage><pub-id pub-id-type="doi">10.1177/1362361319869118</pub-id><pub-id pub-id-type="medline">31552746</pub-id></nlm-citation></ref><ref id="ref5"><label>5</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Savage</surname><given-names>MN</given-names> </name><name name-style="western"><surname>Tomaszewski</surname><given-names>BT</given-names> </name><name name-style="western"><surname>Hume</surname><given-names>KA</given-names> </name></person-group><article-title>Step it up: increasing physical activity for adults with autism spectrum disorder and intellectual disability using supported self-management and Fitbit technology</article-title><source>Focus Autism Other Dev Disabl</source><year>2022</year><month>09</month><volume>37</volume><issue>3</issue><fpage>146</fpage><lpage>157</lpage><pub-id pub-id-type="doi">10.1177/10883576211073700</pub-id></nlm-citation></ref></ref-list></back></article>