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This paper is in the following e-collection/theme issue:

RCTs - Protocols/Proposals (eHealth) (1387) Web-based and Mobile Health Interventions (5936) Digital Mental Health Interventions, e-Mental Health and Cyberpsychology (3339) Cost-Effectiveness and Economics (518) Depression and Mood Disorders; Suicide Prevention (2518)

Published on in Vol 15 (2026)

This is a member publication of University College London (Jisc)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/80511, first published .
Therapist taking notes on patient record during a counseling session.

Clinical and Cost-Effectiveness of Blended Cognitive Behavioral Therapy or Psychodynamic Therapy Versus Face-to-Face Psychotherapy for Depression (BLENDED Study): Protocol for a Pragmatic, Multicenter, Assessor-Blinded Randomized Controlled Noninferiority Trial

Clinical and Cost-Effectiveness of Blended Cognitive Behavioral Therapy or Psychodynamic Therapy Versus Face-to-Face Psychotherapy for Depression (BLENDED Study): Protocol for a Pragmatic, Multicenter, Assessor-Blinded Randomized Controlled Noninferiority Trial

Authors of this article:

Patrick Luyten1, 2 Author Orcid Image ;   Danielle Speybrouck2 Author Orcid Image ;   Peter Martin3 Author Orcid Image ;   Stephan Claes4 Author Orcid Image ;   Nick Midgley1 Author Orcid Image ;   Hester van Eeren5 Author Orcid Image ;   Jan van Busschbach5 Author Orcid Image ;   Eileen Tang2 Author Orcid Image
Article Authors Cited by (1) Tweetations (1) Metrics

Journals

  1. Riper H, Kleiboer A, Hoogendoorn A, Bosmans J, Schulte M, Mathiasen K, Hazo J, Holtzmann J, Chevreul K, Ebert D, Titzler I, Berking M, Funk B, van Schaik A, Kemmeren L, Cieslak R, Smoktunowicz E, Maj A, Botella C, Garcia-Palacios A, Banos R, Herrero R, Andersson G, Topooco N, Vernmark K, Berger T, Krieger T, Cerga-Pashoja A, Doukani A, Araya R, Karyotaki E, Kolovos S, Hoogendoorn M, van Breda W, van de Ven P, Rocha A, Gonçalves G, Cuijpers P. Clinical Effectiveness and Cost-Effectiveness of Blended Treatment for Major Depression Compared With Treatment as Usual Within Routine Care in Europe: A Noninferiority Randomized Controlled Trial. Interactive Journal of Medical Research 2026;15:e72866 View