This paper is in the following e-collection/theme issue:

RCTs - Protocols/Proposals (eHealth) (685) Depression and Mood Disorders; Suicide Prevention (1717) Cost-Effectiveness and Economics (363) Digital Mental Health Interventions, e-Mental Health and Cyberpsychology (2167) Web-based and Mobile Health Interventions (4081)

Published on in Vol 15 (2026)

This is a member publication of University College London (Jisc)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/80511, first published .
Clinical and Cost-Effectiveness of Blended Cognitive Behavioral Therapy or Psychodynamic Therapy Versus Face-to-Face Psychotherapy for Depression (BLENDED Study): Protocol for a Pragmatic, Multicenter, Assessor-Blinded Randomized Controlled Noninferiority Trial

Clinical and Cost-Effectiveness of Blended Cognitive Behavioral Therapy or Psychodynamic Therapy Versus Face-to-Face Psychotherapy for Depression (BLENDED Study): Protocol for a Pragmatic, Multicenter, Assessor-Blinded Randomized Controlled Noninferiority Trial

Clinical and Cost-Effectiveness of Blended Cognitive Behavioral Therapy or Psychodynamic Therapy Versus Face-to-Face Psychotherapy for Depression (BLENDED Study): Protocol for a Pragmatic, Multicenter, Assessor-Blinded Randomized Controlled Noninferiority Trial

Authors of this article:

Patrick Luyten1, 2 Author Orcid Image ;   Danielle Speybrouck2 Author Orcid Image ;   Peter Martin3 Author Orcid Image ;   Stephan Claes4 Author Orcid Image ;   Nick Midgley1 Author Orcid Image ;   Hester van Eeren5 Author Orcid Image ;   Jan van Busschbach5 Author Orcid Image ;   Eileen Tang2 Author Orcid Image
Article Authors Cited by Tweetations Metrics

Patrick Luyten   1, 2 , PhD ;   Danielle Speybrouck   2 , MSc ;   Peter Martin   3 , PhD ;   Stephan Claes   4 , PhD, MD ;   Nick Midgley   1 , PhD ;   Hester van Eeren   5 , PhD ;   Jan van Busschbach   5 , PhD ;   Eileen Tang   2 , PhD

1 Research Department of Clinical, Educational and Health Psychology, University College London, London, United Kingdom

2 Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium

3 Institute of Epidemiology and Health Care, University College London, London, UK

4 University Psychiatric Center KU Leuven, Universitair Ziekenhuis Leuven, Leuven, Belgium

5 Erasmus University Rotterdam, Rotterdam, The Netherlands

Corresponding Author:

  • Patrick Luyten, PhD
  • Faculty of Psychology and Educational Sciences
  • KU Leuven
  • Tiensestraat 102 box 3722
  • Leuven 3000
  • Belgium
  • Phone: 32 16-32-61-35
  • Email: p.luyten@ucl.ac.uk