RCTs - Protocols/Proposals (non-eHealth)

Effects of Allulose vs Aspartame Consumption on Postprandial Glucagon-Like Peptide-1 Profiles and Metabolic Health: Protocol for a Randomized, Crossover, Double-Blind, Placebo-Controlled Trial

Selina Busch, Paola G Ferrario, Ann-Kathrin Henk, Ann Katrin Engelbert, Oliver Wittek, Stephanie Seifert, Achim Bub, Carina I Mack, Bettina Hieronimus

JMIR Res Protoc 2026 (Feb 19); 15:e81857

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Immediate and Sustained Effects of Intensive Equine-Assisted Physiotherapy Based on Neuroproprioceptive “Facilitation and Inhibition” on Psychomotor Development, Clinical Functions, Quality of Life, and Molecular Biological Indicators in Children With Spinal Muscular Atrophy: Protocol for a Crossover Randomized Controlled Trial

Katerina Marikova, Jindra Reissigova, Miloslav Vilimek, Marie Cerna, Marketa Pokorna, Kamila Rasova

JMIR Res Protoc 2026 (Feb 19); 15:e83266

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Evaluation of the Effectiveness of Injectable Platelet-Rich Fibrin as an Adjuvant to One-Stage Full-Mouth Disinfection in Patients with Stage II and III Periodontitis: Protocol for a Randomized Clinical Trial

Mahima Kothekar, Pavan Bajaj, Sneha Dare, Shivani Thakre

JMIR Res Protoc 2026 (Feb 19); 15:e81032

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Impact of the Population Medicine Multimorbidity Intervention in Xishui County (POPMIX) on People at High Risk for Chronic Obstructive Pulmonary Disease: Protocol for the POPMIX-COPD Cluster Randomized Controlled Trial

Chen Wang, Yuhao Liu, Ke Huang, Zhoutao Zheng, Shiyu Zhang, Wenjin Chen, Xingyao Tang, Zhong Cao, Xunliang Tong, Lei Tang, Jinghan Zhao, Liu He, Lirui Jiao, Yingping Wang, Tianying Zhao, Yingchi Luo, Qiande Lai, Xiangqin Lyu, Qiushi Chen, Aditi Bunker, Sebastian Vollmer, Pascal Geldsetzer, Dean Jamison, Till Bärnighausen, Ting Yang, Simiao Chen, POPMIX Group

JMIR Res Protoc 2026 (Feb 18); 15:e85597

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Efficacy of Tuina for Myopia in Children: Protocol for a Randomized Controlled Trial

Shouyao Zhang, Yanju Han, Lijuan Zhang, Fang Tan, Xueping Huang, Can Zhang, Zheng Yao, Lei Xiong, Xiantao Tai

JMIR Res Protoc 2026 (Feb 12); 15:e79324

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Effect of Du-Moxibustion Combined With Spine-Pinching Therapy on Cognitive Frailty in Older Adults With Prefrailty: Protocol for a Randomized Controlled Trial

Suzhen Liu, Mengxia Qi, Hua-Fang Li, Ziqiu Ye, Yu Xu, Xiangying Yang

JMIR Res Protoc 2026 (Feb 10); 15:e82683

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Effects of Acupuncture-Combined Tuina on Patients With Knee Osteoarthritis: Protocol for a Randomized Controlled Trial

Chendong Gu, Dong Wei, Kaiyue Zhang, Jinxi Ren, Yihui Qiao, Fengyu Zhang, Yiting Zhu, Zhixian Xu, Yinlong Cao, Shuyi Yao, Hanrui Guo, Yihang Wang, Huan Wang, Lin Wang, Quanliang Wang, Guangxin Guo

JMIR Res Protoc 2026 (Feb 05); 15:e84082

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Enhancing Upper Secondary Students’ Situational Engagement and Cognitive Prerequisites of Learning Through the Physically Active Academic Lessons Intervention: Protocol for a Mixed Methods Cluster Randomized Individual Crossover Trial

Heidi J Syväoja, Susanna Takalo, Tuomas Kukko, Nina Salmela, Harto Hakonen, Janne Kulmala, Heidi Lindfors, Hermanni Oksanen, Pekka Räsänen, Kati Mäkitalo, Tuija H Tammelin

JMIR Res Protoc 2026 (Feb 03); 15:e84601

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Efficacy of Acupuncture for Mild to Moderate Depression in Older People: Protocol for a Randomized Controlled Trial

Qingnan Fu, Kaihui Xiao, Jie Zhang, Yang Li, Yuxian Wang, Molin Jiang, Zengqi Man, Jing Yang, Wei Lu

JMIR Res Protoc 2026 (Jan 30); 15:e79327

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Brief Intervention for Discontinuing Inappropriate Z-Hypnotic Use Among Older Patients in Primary Care: Protocol for a Cluster Randomized Controlled Trial With a Single Crossover

Tahreem Ghazal Siddiqui, Maria Torheim Bjelkarøy, Tone Breines Simonsen, Maria Lie Selle, Christofer Lundqvist

JMIR Res Protoc 2026 (Jan 30); 15:e75670

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Implementation of a Participatory Ergonomics Intervention to Reduce Musculoskeletal and Stress-Related Mental Health Risks in Australian Retail Workers: Protocol for a Randomized Controlled Trial

Elise Condie, Victoria Weale, Katrina A Lambert, Jodi Oakman

JMIR Res Protoc 2026 (Jan 29); 15:e84864

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Clinical Efficacy and Safety Assessment of Specific-Mode Electroacupuncture Stimulation Combined With Paclitaxel for Recurrent Malignant Gliomas: Study Protocol for a Single-Arm Trial

Zhaoxing Jia, Tianxiang Jiang, Yiqing Zhang, Qianyue Chen, Zhong Di, Qi Yuan, Kecheng Qian, Lin Gan, Congcong Ma, Xianming Lin

JMIR Res Protoc 2026 (Jan 29); 15:e84593

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A Home-Based Intervention to Improve Adherence to the 24-Hour Movement Guidelines in Young Children: Protocol for a Mobile App–Based Randomized Control Trial

Chelsea L Kracht, Jerica M Berge, Monique LeBlanc, Robert L Newton Jr, Ryan E Rhodes, Grace Bolamperti, Madigan Snodgrass, Leanne M Redman

JMIR Res Protoc 2026 (Jan 29); 15:e75621

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Acupuncture Prescription Based on Thermal-Sensitized Acupoints for the Treatment of Knee Osteoarthritis: Protocol for a Randomized Controlled Pilot Trial

Xue-Zhou Wang, Tao-Tao Lv, Kua-Yue Zhang, Zhuo-Ya Chen, Li-Na Qin, Wei-Juan Gang, Wei-Heng Chen, Bao-Hong Mi

JMIR Res Protoc 2026 (Jan 28); 15:e81837

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Real-World Effectiveness and Noninferiority Evaluation and Comparison of Messenger RNA–Based and Protein-Based COVID-19 Vaccines: Protocol for the BEEHIVE Randomized Study With a Hybrid Effectiveness Design

Sarang K Yoon, German L Ellsworth, Steph Battan-Wraith, Andrew L Phillips, Rebecca V Fink, Joshua Griffin, Elizabeth A K Rowley, Jacob McKell, Ashley S Smith, Riley Campbell, Jesse Williams, Sarah W Ball, Hongwei Zhao, Brandy Warren, Matthew D Rousculp, Matthew S Thiese

JMIR Res Protoc 2026 (Jan 27); 15:e80858

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Effectiveness and Safety of Kangjia Decoction Granules for the Treatment of Hashimoto Thyroiditis: Protocol for a Randomized, Double-Blinded, Placebo-Controlled, Multicenter Clinical Trial

Duanchun Zhang, Dan Zhang, Xiaoxiao Qu, Huihong Cao, Yanming He

JMIR Res Protoc 2026 (Jan 26); 15:e80993

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Efficacy, Safety, and Economic Impact of Cytisinicline Maintenance Therapy in Patients Who Are Candidates for Smoking Cessation: Protocol for a Phase IV, Multicenter, Randomized, Open-Label, Controlled, Parallel Clinical Trial (CITISILONG Trial)

Carlos Rabade Castedo, Ana Estany-Gestal, Carlos A Jiménez Ruiz, José Ignacio de Granda-Orive, Juan Antonio Riesco-Miranda, María Isabel Cristóbal Fernández, Angela Ramos-Pinedo, Jaime Signes-Costa Miñana, María Inmaculada Gorordo-Unzueta, Agustin Valido-Morales, Jacobo Sellarés -Torres, Eva Cabrera-César, Alejandro Frino-García, Luis Valdés Cuadrado

JMIR Res Protoc 2026 (Jan 23); 15:e76815

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Curative Effect and Autonomic Nerve Function of Patients With Primary Insomnia of Liver Depression and Spleen Deficiency Type Based on the Acupoint Selection of Meridian Theory: Protocol for a Randomized Controlled Trial

Su Fu, Kang He, Chuanlong Zhou

JMIR Res Protoc 2026 (Jan 22); 15:e84122

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Jiedu Xiaozhen Granules for Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor–Mediated Skin Toxicity: Protocol for a Randomized Controlled Trial

Shoujiang Hao, Xiaoli Li, Shulan Hao, Xiaoying Zhang, Xiaojun Qi, Gang Jin, Fangfang Shen, Likun Liu

JMIR Res Protoc 2026 (Jan 22); 15:e79579

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Normalization of Gastrointestinal Symptoms in Adults With Constipation With Daily Green Kiwifruit Consumption: Protocol for an Open-Label Intervention Study

Jasjot Maggo, Hwei Min Ng, Simone Birgit Bayer, Catherine L Wall, Caroline L Hoad, Luca Marciani, Jane Mullaney, Diana Cabrera, Karl Fraser, Janine M Cooney, Catrin S Günther, Tania Trower, Jeffery Tang, Olivier Gasser, Amber Milan, Warren C McNabb, Robin Spiller, Tamlin Conner, Chris Frampton, Meika Foster, Nicole C Roy, Richard B Gearry

JMIR Res Protoc 2026 (Jan 13); 15:e75286

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