RCTs - Protocols/Proposals (non-eHealth)

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Articles published in 2026 in this theme: 99 (scroll down to load remaining articles)

2026

Therapist massaging man's back with elbows on massage table

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Effectiveness of Tuina Therapy for Patients With Chronic Fatigue Syndrome: Protocol for a Multicenter, Randomized, Open-Label, Assessor-Blinded, Parallel-Group Clinical Trial

Jun Ren, Shoujian Wang, Sitong Fang, Shanda Xu, Chaoqun Xie, Ming Jin, Xingyu Zhou, Wu Li, Yan Zhao, Xingquan Wu, Cheng Wang, Yanguo Wang, Zhichao Gong, Jing Zhou, Junjie Yao, Xue Bai, Yu Wang, Min Fang, Lingjun Kong

JMIR Res Protoc 2026 (Sep 01); 15:e94022

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Plus-size woman exercises with dumbbells on a fitness ball at home

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Physical and Psychological Effects of Home-Based vs Face-to-Face Prehabilitation in Individuals With Severe Obesity Awaiting Bariatric and Metabolic Surgery: Protocol for a Randomized Controlled Trial

Darlan Laurício Matte, Guilherme Torres Vilarino, Alexandro Andrade, Ananda Quaresma Nascimento

JMIR Res Protoc 2026 (Aug 28); 15:e87053

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Yoga sequence: Sun Salutation A (Surya Namaskar A) poses for beginners.

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Auricular Acupressure for Perioperative Anxiety and Pain in Therapeutic Breast Surgery: Protocol for a Randomized Clinical Trial

Mirela Bilc, Eva Beiner, Johanna Triana, Irene Rubio Rodríguez, Anja Birmanac-Pflüger, Holger Cramer, Marcela Winkler

JMIR Res Protoc 2026 (Aug 21); 15:e97469

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Physical therapy session: patient receives electrotherapy, another patient undergoes neck treatment.

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Electrical Dry Needling and Therapeutic Exercise Versus Therapeutic Exercise in Patients With Chronic Nonspecific Neck Pain: Protocol for a Randomized Controlled Trial

Inmaculada C Lara-Palomo, Adrián Bautista-Rodríguez Sr, Jose María Muñoz-Manzaneda Sr, Elena Álvarez-López, Elena Barragán-Olea, Adelaida María Castro-Sánchez

JMIR Res Protoc 2026 (Aug 20); 15:e91491

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Flowchart of a supervised multicomponent exercise program for older adults in frailty and pre-frail stages.

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Influence of a Multicomponent Supervised Exercise Program on Frail and Prefrail Community-Dwelling Older Adults: Protocol for a Randomized Controlled Trial

Ana Paula Felix Arantes, Fabiana Machado Pires, Caroline Brand, Rodrigo Franco Oliveira, Deise Aparecida de Almeida Pires Oliveira

JMIR Res Protoc 2026 (Aug 18); 15:e93130

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Nurse adjusts oxygen nasal cannula on smiling patient in hospital room.

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Study of High-Velocity Nasal Insufflation vs Noninvasive Positive Pressure Ventilation for Emergency Type 2 Respiratory Failure: Protocol for a Noninferiority Randomized Controlled Trial

Mui Teng Chua, Darius Shaw Teng Pan, Alexander Jet Yue Ng, Crystal Harn Wei Soh, Win Sen Kuan

JMIR Res Protoc 2026 (Aug 14); 15:e93391

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Doctor places a transcranial magnetic stimulation (TMS) coil on a patient's head.

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Effect of Low-Intensity Transcranial Focused Ultrasound Stimulation on Neuropathic Pain: Protocol for a Randomized, Single-Blind, Placebo-Controlled, 3-Arm, Parallel-Group Trial

Nobuhiko Mori, Yuhei Hoshikuma, Koichi Hosomi, Akihiro Yamamoto, Takeshi Shimizu, Hui Ming Khoo, Naoki Tani, Satoru Oshino, Haruhiko Kishima

JMIR Res Protoc 2026 (Aug 14); 15:e95379

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Woman wearing a face mask and holding her chest, suggesting discomfort.

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Efficacy of Liuzijue in Improving Respiratory Muscle Dysfunction in Chronic Obstructive Pulmonary Disease: Protocol for a Randomized Controlled Trial

Yiting Ni, Wei Feng, Wangtao Cai, Yuxin Sun, Min Cao, Juhan Chen, Jian Li

JMIR Res Protoc 2026 (Aug 10); 15:e91283

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Diagram on laptop screen showing immune response to a virus, with antibody binding.

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Integrated Traditional Chinese and Western Medicine for Chronic Spontaneous Urticaria: Protocol for a Trials Within Cohorts Study

Linhao Li, Sihan Wang, Jiale Chen, Xiaojie Ding, Yifei Wang, Fei Guo, Xiaoying Sun, Liu Liu, Xin Li

JMIR Res Protoc 2026 (Aug 04); 15:e88251

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Medical professionals in a meeting discussing patient data on a laptop.

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Development and Validation of a Culturally Competent Care Module and Its Effect on Nurses’ Cultural Competence and Patient Satisfaction: Protocol for a Randomized Controlled Trial in a Tertiary Care Hospital in India

Ligy C Ittup, Ranjana Sharma

JMIR Res Protoc 2026 (Jul 29); 15:e84015

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SAMBA-II diagnostic instrument with tablet interface and lab supplies.

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Feasibility, Acceptability, and Test Performance of Point-of-Care Nucleic Acid Tests for HIV Testing and Viral Load Monitoring in the United States: Prospective Longitudinal Mixed-Methods Study

Lisa A Niemann, Lauren R Violette, Andy Cornelius-Hudson, Maggie Murphy, Carl Capili, Mindy Dai, Anjuli Wagner, Sarah Frey, Shireesha Dhanireddy, Shaneil E Taylor, Karen W Hoover, Joanne D Stekler

JMIR Res Protoc 2026 (Jul 23); 15:e84625

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Manual Versus Instrumental Rotation of the Fetal Head in Malposition at Birth (ROTATE Study): Protocol for a Randomized Controlled Trial

Dawn Parris, Raffaele Napolitano, Jonathan Bishop, Annette Briley, Laura Butler, Versha Cheed, Anna L David, Zaina Habib, Pollyanna Hardy, Kim Hinshaw, Laura L Jones, Rachel Lillywhite, Eleanor Molloy, Jacqueline Nicholls, Stephen O'Brien, Rachel Plachcinski, Andrew Shennan, Nigel Simpson, Maureen Treadwell, Bassel Wattar, Andrew Weeks, The ROTATE Study Group, Dimitrios Siassakos

JMIR Res Protoc 2026 (Jul 22); 15:e72505

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Close-up of hands massaging the neck and shoulder area of a person lying face down.

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Comparison of Traditional Chinese Manual Therapy (Tuina) and Extracorporeal Shock Wave Therapy in Patients With Nonspecific Neck Pain: Protocol for a Randomized Controlled Trial

Hongyu Li, Lili Zhao, Zhenning Zhao, Jing Mu, Huisheng Ma

JMIR Res Protoc 2026 (Jul 20); 15:e96555

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Close-up of teeth with metal braces and orthodontic wires

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Clinical and Patient-Reported Outcomes of Laceback Ligature in Fixed Orthodontic Treatment: Protocol for a Randomized Controlled Trial

Loon Han Tan, Siti Hajjar Nasir, Joo Ming Cheong, Kumeran Mohan

JMIR Res Protoc 2026 (Jul 16); 15:e88793

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Children and adults holding certificates at an awards ceremony

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Optimizing Multicomponent Interventions to Improve Child Mental Health Following Reintegration From Institutions: Protocol for a Factorial Randomized Trial

Leyla Ismayilova, Narmin Guliyeva, Fuad Ismayilov, Emma Heidorn, Fred Ssewamala, Kerim Munir, Deborah Gorman-Smith, Emily Claypool, Parvin Muslumzada, Loren Beard, Donald Hedeker

JMIR Res Protoc 2026 (Jul 16); 15:e93033

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Infographic detailing a lung cancer screening trial: population, design, and outcomes.

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Clinical Study on the Prevention of High-Risk Pulmonary Nodule Progression With Yifei Sanjie Pill: Protocol for a Multicenter Randomized Controlled Trial

Bo An, Jietao Lin, Lizhu Lin, Xiangjun Qi, Yanlong Li, Minyi Guan, Zhiqiang Chen, Jingrui Wang, Lingling Sun

JMIR Res Protoc 2026 (Jul 15); 15:e78534

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Man doing cable machine chest press exercise in a gym

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Effects of Velocity-Based Resistance Training on Renal Function and Metabolic Health in Kidney Transplant Recipients: Protocol for a Pilot Randomized Controlled Trial

Jhonatan Camilo Peña Ibagon, Fermina Vasquez Osorio, Carlos Andrés Collazos Morales, Blanca Elpidia Tovar, William Felipe Martin1, Yordan Rene Pardo, Luis Andres Tellez

JMIR Res Protoc 2026 (Jul 10); 15:e94010

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Jathyadi Thailam, Thriphala Churna, and infiltration syringe for ano-rectal care

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Efficacy of an Ayurvedic Management Protocol on the Rate of Recurrence, Healing and Safety in Parikarthika (Fissure in Ano): Protocol for a Randomized Controlled Trial

Indu P P, Kalpana Kachare, Pratap Shankar K M, Binitha P, Lisha S, Bhagwan Sahai Sharma, Thugutla Maheswar, Narayanan Srikanth, Arunabh Tripathi, Rabinarayanan Acharya

JMIR Res Protoc 2026 (Jul 08); 15:e88548

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Man pouring instant coffee granules from a sachet into a glass of water

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Efficacy, Safety, and Mechanism of the Qi-Lian-Xiao-Pi Prescription (WW-1) for Chronic Atrophic Gastritis After Helicobacter Pylori Eradication: Protocol for a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

Wei Bai, Guodong Huang, Xianjun Rao, Hao Li, Tingting Zhou, Yang Yang, Wei Wei

JMIR Res Protoc 2026 (Jul 08); 15:e90965

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Person wearing EEG headset at computer, brainwave research

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An Evidence-Based Cognitive Stimulation and Physical Activity Intervention to Delay Aging-Related Decline: Protocol for a Randomized Controlled Trial

Yook Chin Chia, Eden Ngah Den Low, Michael Jenkins, Yun Li Lee, Tin Tin Su, Rozainee Khairudin, Khazriyati Salehuddin, Santha Vaithilingam, Jactty Chew, Wei Ling Lim, Min Hooi Yong, Alexandre Schaefer

JMIR Res Protoc 2026 (Jul 08); 15:e88268

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