Development of a Novel Real-Time Computer-Assisted Colonoscopy Diagnostic Tool for Colorectal Neoplasia and Cancer to Enable Personalized Patient Management: Protocol for a Multicenter Proof-of-Concept Study

Olaolu Olabintan   ^{1, 2} , MBBS ;   Angelo Brunori   ³ , MD ;   Natalie Halvorsen   ^{4, 5} , MD ;   Nils Andersen   ⁶ , BSc ;   Verónica G Zubiaurre   ⁷ , BSc ;   Mehrnaz Mirzaei   ^{8, 9} , BSc ;   Ina Dam Pedersen   ¹⁰ , BSc ;   Alessandro D’Aprano   ¹¹ , BSc ;   Johnathan Sun   ² , BSc ;   Ahmed Ghazwan Waraich   ² , BSc ;   Omer Ahmad   ¹² , MBBS, PhD ;   Nastazja Pilonis   ¹³ , BSc ;   Michal Kaminski   ¹³ , BSc ;   Francisco Lamosa   ¹⁴ , BSc ;   Rune Erichsen   ¹⁰ , BSc ;   Johannes Blom   ^{9, 15} , BSc ;   Thomas Rosch   ⁶ , BSc ;   Maria Pellise   ³ , BSc ;   Ignasi Puig   ^{7, 16, 17} , BSc ;   Cesare Hassan   ^{11, 18} , BSc ;   Kensaku Mori   ¹⁹ , BSc ;   Yuichi Mori   ^{4, 5, 20} , BSc ;   Massashi Misawa   ²⁰ , BSc ;   Shraddha Gulati   ^{1, 2} , MBBS, PhD

¹ King's Institute of Therapeutic Endoscopy, King's College Hospital, London, United Kingdom

² Faculty of Life Science and Medicine, King's College London, London, United Kingdom

³ Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain

⁴ Department of Transplantation Medicine, Gastroenterology Section, Oslo University Hospital, Oslo, Norway

⁵ Clinical Effectiveness Research Group, Institute of Health and Society, University of Oslo, Oslo, Norway

⁶ Klinik und Poliklinik für interdisziplinäre Endoskopie, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

⁷ Digestive Disease Department, Althaia, Manresa, Spain

⁸ Department of Internal Medicine, Stockholm South General Hospital, Stockholm, Sweden

⁹ Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden

¹⁰ Bedøvelse, Operation og Intensiv, Regional Hospital Horsens, Midtjylland, Denmark

¹¹ Department of Biomedical Sciences, Humanitas University, Milan, Italy

¹² Gastroenterology Department, University College Hospital, London, United Kingdom

¹³ Department of Oncological Gastroenterology, National Research Institute of Onclolgy, Warsaw, Poland

¹⁴ Maplesoft Europe, Duxford, United Kingdom

¹⁵ Department of Surgery, Stockholm South General Hospital, Stockholm, Sweden

¹⁶ Facultat de Medicina, Universitat de Vic - Universitat Central de Catalunya, Vic, Spain

¹⁷ Institut de Recerca i Innovació Educativa, Vic, Spain

¹⁸ IRCCS Humanitas Research Hospital, Milan, Italy

¹⁹ Graduate School of Informatics, Nagoya University, Nagoya, Japan

²⁰ Digestive Disease Centre, Showa University Northern Yokohama Hospital, Yokohama, Japan