The Effect of Integrated Aerobic and Cognitive Training (Activ4Brain) on Cognition and Neurophysiology in Older Adults: Protocol for a Controlled Trial

Hicran Besikci   ^{1 *} , MSc ;   Kaan Akalp   ^{2 *} , MSc ;   Luís Rama   ² , PhD ;   Beatriz Branquinho Gomes   ² , PhD ;   José Pedro Leitão Ferreira   ² , PhD ;   Susana Mouga   ^{1, 3} , PhD ;   Inês Bernardino   ¹ , PhD ;   Miguel Castelo-Branco   ^{1, 4} , MD, PhD ;   Ana Rita Sousa e Silva   ⁵ , PhD ;   Ana Maria Teixeira   ² , PhD ;   Maria José Ribeiro   ^{1, 4, 6} , PhD

¹ CIBIT - Coimbra Institute for Biomedical Imaging and Translational Research Coimbra, Instituto de Ciências Nucleares Aplicadas à Saúde (ICNAS), University of Coimbra, Coimbra, Portugal

² Faculty of Sport Sciences and Physical Education, CIPER, University of Coimbra, Coimbra, Portugal

³ Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal

⁴ Faculty of Medicine, University of Coimbra, Coimbra, Portugal

⁵ CINEICC - Center for Research in Neuropsychology and Cognitive Behavioral Interventions, Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal

⁶ RISE-Health, Center for Translational Health and Medical Biotechnology (TBIO), School of Health (ESS), Polytechnic of Porto, Porto, Portugal

*these authors contributed equally