Feasibility of High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumor and Young Adults With Isocitrate Dehydrogenase–Mutant Gliomas (HYPE): Protocol for a Randomized Controlled Trial

Elizabeth Cox   ^{1 *} , PhD ;   Meghan Tahbaz   ^{2 *} , BS ;   Ellaney Matarese   ^{3 *} , AB ;   Rebekah L Wilson   ¹ , PhD ;   L Nicolas Gonzalez Castro   ^{4, 5} , MD, PhD ;   Hajime Uno   ¹ , PhD ;   Tabitha Cooney   ⁶ , MD ;   Jordan Lane   , BS ;   Mary K Norris   , MS ;   Kira Bona   ^{6, 7} , MD ;   Rahela Aziz-Bose   ^{6, 7} , MD ;   Christina M Dieli-Conwright   ^{1, 8} , MPH, PhD

¹ Department of Medicine, Harvard Medical School, Boston, MA, United States

² Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States

³ Department of Neuroscience, Harvard University, Cambridge, MA, United States

⁴ Department of Neurology, Brigham and Women’s Hospital/Mass General Brigham, Boston, MA, United States

⁵ Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, United States

⁶ Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Boston, MA, United States

⁷ Department of Pediatrics, Harvard Medical School, Boston, MA, United States

⁸ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States

*these authors contributed equally