Ayurvedic Therapeutic Regimen as an Add-On to Optimized Conventional Management of Parkinson Disease: Protocol for an Exploratory Randomized Controlled Trial Evaluating Clinical, Cortical Excitability, Neuroimmune, and Autonomic Function Parameters

Umesh Chikkanna   ¹ , MD ;   Pramod Kumar Pal   ² , DM ;   Sophia Jameela   ³ , MD ;   Rohan R Mahale   ² , DM ;   Nitish Kamble   ² , DM ;   Venkataram Shivakumar   ¹ , PhD ;   Bharath Holla   ¹ , PhD ;   Ravi Yadav   ² , DM ;   Vikram V Holla   ² , DM ;   Talakad Narasappa Sathyaprabha   ⁴ , PhD ;   Kaviraja Udupa   ⁴ , PhD ;   Srinibash Sahoo   ⁵ , PhD ;   Manjunath M Venkataswamy   ⁶ , PhD ;   Selva Ganapathy   ⁷ , PhD ;   Chandra Shekara Rao   ³ , MD ;   Babita Yadav   ³ , MD ;   Sreenithya M   ¹ , MD ;   Shivarama Varambally   ⁸ , MD, DSC ;   Sulochana Bhat   ⁵ , MD ;   Narayanam Srikanth   ³ , MD ;   Kishore Kumar Ramakrishna   ¹ , PhD

¹ Department of Integrative Medicine, National Institute of Mental Health and Neurosciences, Bengaluru, India

² Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India

³ Central Council for Research in Ayurvedic Sciences, New Delhi, India

⁴ Department of Neurophysiology, National Institute of Mental Health and Neurosciences, Bengaluru, India

⁵ Central Ayurveda Research Institute, Bengaluru, India

⁶ Department of Neurovirology, National Institute of Mental Health and Neurosciences, Bengaluru, India

⁷ Department of Physiotherapy, National Institute of Mental Health and Neurosciences, Bengaluru, India

⁸ Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India