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This paper is in the following e-collection/theme issue:

RCTs - Protocols/Proposals (funded, already peer-reviewed, eHealth) (629) Mobile Health (mhealth) (5334) mHealth for Wellness, Behavior Change and Prevention (4356) Substance Abuse (687) Behavior Change (1108) Engagement with and Adherence to Digital Health Interventions, Law of Attrition (852)

Published on in Vol 15 (2026)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/108379, first published .
Woman breaking a cigarette in half, symbolizing quitting smoking.

A Randomized Factorial Trial of Varenicline, Nicotine Lozenges, and Smartphone Medication Adherence Reminders for Smoking Cessation: Protocol for the COMBO II Study

A Randomized Factorial Trial of Varenicline, Nicotine Lozenges, and Smartphone Medication Adherence Reminders for Smoking Cessation: Protocol for the COMBO II Study

Authors of this article:

Nathalia M Machado1, 2 Author Orcid Image ;   Jasjit S Ahluwalia3, 4 Author Orcid Image ;   Michael S Businelle1, 5 Author Orcid Image ;   Summer G Frank-Pearce1, 6 Author Orcid Image ;   Irina Baranskaya7 Author Orcid Image ;   Emily T Hébert1, 5 Author Orcid Image ;   Munjireen S Sifat1, 5 Author Orcid Image ;   Shannon H Gwin1 Author Orcid Image ;   Roma Thakur1 Author Orcid Image ;   Sharon Glassman1 Author Orcid Image ;   Henry W Kinnard, Jr8 Author Orcid Image ;   Gaurav Kumar1 Author Orcid Image ;   Deeksha Gupta1 Author Orcid Image ;   Darla E Kendzor1, 5 Author Orcid Image
Article Authors Cited by Tweetations Metrics

Nathalia M Machado   1, 2 , MSc, PhD ;   Jasjit S Ahluwalia   3, 4 , MD, MPH, MS ;   Michael S Businelle   1, 5 , PhD ;   Summer G Frank-Pearce   1, 6 , MPH, PhD ;   Irina Baranskaya   7 , MD ;   Emily T Hébert   1, 5 , MPH, DrPH ;   Munjireen S Sifat   1, 5 , MPH, PhD ;   Shannon H Gwin   1 , PhD ;   Roma Thakur   1 , MSHI ;   Sharon Glassman   1 , BA ;   Henry W Kinnard, Jr   8 , DPh ;   Gaurav Kumar   1 , MPH, PhD ;   Deeksha Gupta   1 , PhD ;   Darla E Kendzor   1, 5 , PhD

1 TSET Health Promotion Research Center, Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, OK, United States

2 Department of Internal Medicine, University of Oklahoma Health Campus, Tulsa, OK, United States

3 Department of Behavioral and Social Sciences and Center for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI, United States

4 Department of Medicine, Alpert Medical School, Brown University, Providence, RI, United States

5 Department of Family and Preventive Medicine, University of Oklahoma Health Campus, Oklahoma City, OK, United States

6 Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Campus, Oklahoma City, OK, United States

7 Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Campus, Oklahoma City, OK, United States

8 College of Pharmacy, University of Oklahoma Health Campus, Oklahoma City, OK, United States

Corresponding Author:

  • Nathalia M Machado, MSc, PhD
  • TSET Health Promotion Research Center, Stephenson Cancer Center, University of Oklahoma Health Campus
  • 655 Research Parkway
  • Oklahoma City, OK 73104
  • United States
  • Phone: 1 (405) 271-6872
  • Email: nathalia-munckmachado@ou.edu