RCTs - Protocols/Proposals (funded, already peer-reviewed, eHealth)

Articles published in this theme: 421 (scroll down to load remaining articles)

2026

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Optimizing Engagement with Digital Mental Health Resources Among Sexual and Gender Minority Users: Protocol for a Series of Microrandomized Trials

Meghan Romanelli, Theresa Nguyen, Kevin Rushton, John Marion

JMIR Res Protoc 2026 (Jun 30); 15:e97126

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A Clinician-Supported Mobile App to Reduce Mental Health Symptoms Among World Trade Center Responders in Florida: Protocol for a Randomized Controlled Trial

Mark J Macgowan, Kyle Possemato, Eric Kuhn, Nan Hu, Sandra Lowe, Stephanie Garcia, Isis Panellas, Arrianna Edwards, Victoria Gray, Ruth Marquez, Luciana Pitta, Roberto G Lucchini

JMIR Res Protoc 2026 (Jun 30); 15:e95229

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Evaluation of a Digital Intervention for Monitoring and Improving Medication Adherence Among Real-World e-Consumers of HIV Preexposure Prophylaxis in China: Protocol for a Randomized Controlled Trial

Jingtao Zhou, Qingyu Li, Jiayin Zheng, Huang Xiao, Yuhang Zhang, Siwen Huang, Chi Ruan, Zhiyi Zhao, Chunqing Lin, Huachun Zou, Xianlong Ren, Houlin Tang, Hui Xue, Sitong Luo

JMIR Res Protoc 2026 (Jun 29); 15:e92750

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A Metacognitive Intervention for Children and Adolescents in Neuropediatric Care (Mio-Training): Protocol for a Randomized Controlled Trial

Saskia Salzmann, Rhoikos Furtwängler, Regula Everts, Sebastian Grunt, Valentin Benzing

JMIR Res Protoc 2026 (Jun 26); 15:e95139

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Development of Data-Driven Models for Just-in-Time Digital Self-Management Advice to Improve Physical Functioning in Hip and Knee Osteoarthritis: Protocol for the e-cOAch Cross-Over Study

Femke Groen, Mariëtte de Rooij, Corelien J J Kloek, Cindy Veenhof, Michel C A Klein, Abdallah Al-Janabi, Erik S van Haeringen, Amber Ronteltap, Bas Paans-Cijs, Britt van Dongen, Dorien E Ginsel, Di-Janne A Barten, Thomas J Hoogeboom, Martijn F Pisters

JMIR Res Protoc 2026 (Jun 22); 15:e94709

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Testing a Web-Based Parent-Focused HIV Prevention Intervention for Gay and Bisexual Adolescents: Protocol for a Randomized Controlled Trial

David M Huebner, Brian RW Baucom, Stephanie Micucci, Andrew P Barnett, Maggie Matson, Vincent Guilamo-Ramos, Jenny Mackenzie, Rana Saber

JMIR Res Protoc 2026 (Jun 22); 15:e81316

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Effects of a Home-Based Exercise Program Incorporating Mindfulness and Yoga on Balance and Mobility in People With Parkinson Disease: Protocol for a Randomized Controlled Trial

Jojo Yan Yan Kwok, Lily Man Lee Chan, Yuki Yuk Shum, Shirley Yin Yu Pang, Man Auyeung, Bastiaan R Bloem

JMIR Res Protoc 2026 (Jun 03); 15:e97781

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Creation of an mHealth Infrastructure to Support the Development and Delivery of mHealth Interventions: Protocol for Demonstration Projects Addressing Smoking Cessation in Cancer Care

Lindsey S Sparrock, Jennifer I Vidrine, Christine E Vinci, Issam M El Naqa, Steven K Sutton, Ramzi G Salloum, Jesse Dallery, Tracy E Crane, Frank J Penedo, Samuel J Brockway, Sarah R Jones, Charles E Hoogland, Richard R Reich, Guillermo Gonzalez-Calderon, Vani N Simmons, Damon J Vidrine

JMIR Res Protoc 2026 (May 29); 15:e92288

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Telehealth Versus In-Person Caregiver-Mediated Behavioral Treatment for Challenging Behaviors in Children With Autism Spectrum Disorder: Protocol for COACH (Caregiver Outreach for Autism Coaching at Home) Randomized Controlled Trial

Joy S Pollard, Leslie S Quiroz, Jennifer A Boyd, Booil Jo, Scott S Hall

JMIR Res Protoc 2026 (May 26); 15:e91840

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Evaluating a Multimedia Messaging Intervention to Increase Adolescent HIV Testing: Protocol for a Hybrid Type 1 Effectiveness Implementation Study

Kathryn Macapagal, Andrés Alvarado Avila, Zach M Buehler, Jacob Gordon, Ashley Knapp, Manuel Hurtado Jr, Julianna Lorenzo, James Foran, Michael E Newcomb, Brian Mustanski, Dennis H Li, Gregory Swann, Mariajosé J Paton, Rana Saber, Elizabeth Casline

JMIR Res Protoc 2026 (May 18); 15:e88465

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REVISE Virtual Reality Intervention to Prevent Sexual Harassment in Heterosexual Couples: Protocol for a Randomized Controlled Trial

Alejandro Saavedra-Roa, Pablo Vallejo-Medina, Sofia Seinfeld, Pierre Bourdin-Kreitz, Alejandro Guillén-Riquelme, Ferran Marsa-Sambola, Joan C Medina, Claudia Pineda-Marin, Clara Paz, Ariadna Angulo-Brunet, Adrian Montesano

JMIR Res Protoc 2026 (May 14); 15:e91993

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Evaluating Patient-Entered Electronic Health Data as a Strategy to Improve Quality of Care in a Diabetes Clinic: Protocol for a Randomized Controlled Trial

Julia Hunter-Schouela, Lindsey Ure, Caroline Zuijdwijk, Elias Abou-Assaly, Alexandra Ahmet, Jennifer de Boer, Karine Khatchadourian, Stephen A Kutcher, Sarah E Lawrence, Deepti Reddy, Richard Webster, Ellen B Goldbloom

JMIR Res Protoc 2026 (May 08); 15:e89519

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Progressive Achilles Loading via Clinician e-Support (PACE): Protocol for a Dual-Site Randomized Controlled Trial

Micah A K M Wong, Mathew Frazier, Ryan Jensen, Timothy Fleagle, Barbara Van Gorp, Nicole Hall, Patrick Ten Eyck, Linder Wendt, Molly Pacha, Jessica Danielson, Mederic Hall, Jason Wilken, Ruth L Chimenti

JMIR Res Protoc 2026 (Apr 07); 15:e90955

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A Culturally Tailored Mobile Health Intervention to Improve Quality of Life in Black Survivors With Prostate Cancer: Protocol for a Stratified Randomized Controlled Trial

Gaurav Kumar, Parisa Ghasemi, Adam C Alexander, Kathleen Dwyer, Jordan M Neil, Perry Cole, Patrick Beckford, Donald Reese, Everett Montgomery, Roland Odeleye, Mark A Harris, Yan D Zhao, Zsolt Nagykaldi, Andrew G McIntosh, Ernie Kaninjing, Mary E Young, Sabrina Dickey, Daniel J Morton, Opeyemi Bolajoko, Folakemi T Odedina, Lourdes G Planas, Michael S Businelle, Darla E Kendzor, Motolani E Ogunsanya

JMIR Res Protoc 2026 (Mar 24); 15:e81503

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Feasibility of Vigorous Extended Reality Tele-Exergaming for Cardiometabolic Health in Youth With Mobility Disabilities: Protocol for a Case Series Study

Byron Lai, Maggie Logan, Raven Young, Ashley Wright, Jordyn Terrell, Larsen Bright, Drew Davis, Christen J Mendonca

JMIR Res Protoc 2026 (Feb 27); 15:e85246

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The Third Study of Infectious Intestinal Disease (IID3 Study) in the Community: Protocol for UK-Based Prospective Cohort Studies Investigating the Disease Burden

Ben W Rowland, Vanashree Sexton, Aileen Mill, Stephen Rushton, Roy Sanderson, Caroline Grundy, Simon de Lusignan, Nigel A Cunliffe, Daniel Hungerford, Mark Hopkins, Saheer Gharbia, Claire Jenkins, Gauri Godbole, Roberto Vivancos, Alex J Elliot, Dominic J Mellor, Lesley Larkin, Rachel Chalmers, Sarah O'Brien, IID3 Consortium

JMIR Res Protoc 2026 (Feb 25); 15:e88759

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Feasibility and Acceptability of Collaborative Augmented Reality for Older Adults and Companions: Protocol for a Randomized Controlled Trial

Nilanjan Sarkar, Judith A Tate, Mahrukh Tauseef, Akshith Ullal, Cathy A Maxwell, Lisa A Juckett, Douglas W Scharre, Alai Tan, Rendong Zhang, Zalen Ingram, Lorraine C Mion

JMIR Res Protoc 2026 (Feb 11); 15:e83864

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Evaluating the Effectiveness of the Motivational Interviewing–Based Wellness Coaching for Kids and Families (WC4K) Program in Pediatric Obesity Care: Protocol for a Cluster Randomized Pragmatic Trial

Corinna Koebnick, Margo Sidell, Jessica D Vallejo, Xia Li, Emerson Delacroix, Deborah Young, Poornima Kunani, Ken Resnicow

JMIR Res Protoc 2026 (Feb 10); 15:e78792

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Virtual Reality to Improve Pain Management and Mental Health in Stroke Survivors With Chronic Pain: Study Protocol for a Feasibility Randomized Controlled Trial on Virtual Reality-Acceptance and Commitment Therapy

Sérgio A Carvalho, Paulo Menezes, Catarina Duarte, David Skvarc, Ana Rita Sousa e Silva, Ana Valentim, João Emanuel Diogo, João Sargento-Freitas, Inês A Trindade, Paula Castilho, Teresa Lapa, Gerhard Andersson, Miguel Castelo-Branco

JMIR Res Protoc 2026 (Feb 06); 15:e80611

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A Smartphone-Based Psychological Intervention for Nonsuicidal Self-Injury (Kalmer App): Protocol for a Multicenter Double-Blind Randomized Controlled Trial

Anna Julià, Irene Jaén, Mónica Conesa Giménez, Azucena García-Palacios, Juan C Pascual, Anna Sintes Estévez, Anaís Lara, Iria Méndez, Soledad Romero, Joaquim Puntí, Joaquim Soler, Jordi Solé-Casals, Marina López-Solà, Daniel Vega

JMIR Res Protoc 2026 (Jan 27); 15:e86413

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