In Vitro Characterization of the Immune Response to an Epitope Ensemble Vaccine Against Rhinovirus in Pediatric Asthma and Adults With Chronic Obstructive Pulmonary Disease: Protocol for an Observational and Exploratory Study

Sara Alonso Fernandez   ^{1 *} , BSc ;   Raquel Reyes-Manzanas   ^{1 *} , PhD ;   Susana Camara   ² , PhD ;   Juan Mozas-Gutierrez   ¹ , BSc ;   Myriam Calle-Rubio   ^{3, 4, 5} , MD ;   Juan Rodriguez-Hermosa   ^{3, 4, 5} , MD ;   Andres Bodas-Pinedo   ^{4, 5, 6} , MD ;   Santiago Rueda Esteban   ⁶ , MD ;   Esther M Lafuente   ¹ , PhD ;   Jesús Reiné   ^{1, 2, 7, 8 *} , PhD ;   Pedro A Reche   ^{1 *} , PhD

¹ Department of Immunology, Ophthalmology and ORL, Faculty of Medicine, Universidad Complutense de Madrid, Madrid, Spain

² Department of Paediatrics, Oxford Vaccine Group, University of Oxford, Oxford, United Kingdom

³ Unit of Pulmonology, Hospital Clínico San Carlos, Madrid, Spain

⁴ Department of Medicine, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain

⁵ Health Research Institute (IdISSC), Hospital Clínico San Carlos, Madrid, Spain

⁶ Paediatrics Unit, Hospital Clínico San Carlos, Madrid, Spain

⁷ Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

⁸ Centre of Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala

*these authors contributed equally