Non-Randomized Study Protocols and Methods (Non-eHealth)

Articles published in 2025 in this theme: 109 (scroll down to load remaining articles)

2025

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Clinical Effectiveness and Cost-Effectiveness of Collaborative Treatment With Korean and Western Medicine for Primary Headache Disorders: Protocol for a Multicenter Prospective Observational Study

Jaeseung Kim, Jihwan Yun, Linae Kim, Shiva Raj Acharya, Changyon Han, NamKwen Kim

JMIR Res Protoc 2025 (Dec 30); 14:e82819

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Gut Microbiota, Antipsychotics, and Metabolic Alterations in Children and Adolescents: Protocol for a Longitudinal Observational Study

Marcela França Dias, Ana Paula de Alcântara Freitas, Suzana Figueiredo Collares, Renata Maria Silva Santos, Yago Jean de Almeida Nogueira, Antônio Márcio de Ávila Júnior, Tamires Coelho Martins, Paulo Marcos Brasil Rocha, Marco Aurélio Romano-Silva, Débora Marques de Miranda

JMIR Res Protoc 2025 (Dec 29); 14:e77374

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Establishing Barriers to and Enablers of Nurse-Enabled Subcutaneous Therapy Self-Administration Programs for Patients With Myeloma: Protocol for a Qualitative Descriptive Study

Hayley Beer, Lisa Guccione, Amit Khot, Simon Harrison, Meinir Krishnasamy

JMIR Res Protoc 2025 (Dec 23); 14:e85053

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Perceptions, Barriers, and Facilitators of Provider-Initiated and Voluntary HIV Testing and Counseling Among Health Care Workers: Protocol for a Multicenter Cross-Sectional Study

Bingyi Wang, Leiwen Fu, Ke Liu, Cailing Ao, Simin He, Shilan Xie, Liwei Wan, Guoren Wang, Zhen Lu, Yong Lu, Fang Yang, Yan Li, Xiaobing Fu, Huihong Deng

JMIR Res Protoc 2025 (Dec 22); 14:e69832

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IL-6/GP130/JAK/STAT3 Pathway Activation in Pancreatic Ductal Adenocarcinoma and Its Association With Clinical Features: Protocol for a Retrospective Cross-Sectional Study

Claudia Mellenthin, Fabien Schaller, Lucie Vignot, Sarah Peisl, Rita Vesce, Irene Esposito, Carmen Gonelle-Gispert, Cornelia Schneider, Michel Adamina, Leo Hans Bühler

JMIR Res Protoc 2025 (Dec 15); 14:e76811

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The Effect of Semaglutide With Lifestyle Intervention on the Physical Health of Patients Treated With Antipsychotic Drugs in a Secure Mental Health Setting: Protocol for an Uncontrolled Pretest-Posttest Pilot Mixed Methods Study

Kristina Brenisin, Florence Kinnafick, James King, Louise Millard, Donna Arya, Elizabeth Hodgson, Michelle Huggins, Andrew Simmons-Roberts, Martin O'Dowd, Nick Rayment, Parul Shah, Kieran C Breen

JMIR Res Protoc 2025 (Dec 09); 14:e76013

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Real-World Efficacy and Safety of Zishenyizhi Pill for Cognitive Impairment Associated With Cerebral Small Vessel Disease: Protocol for a Multicenter Prospective Observational Study

Xiongxing Sun, Yao Xie, Rui Fang, Shanshan Zeng, Shigao Lin, Xukun Tang, Jie Tang, Tenghui Hu, Yuhui Zhang, Le Xie, Dahua Wu

JMIR Res Protoc 2025 (Dec 08); 14:e77661

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The White Matter Hyperintensity Shape and Brain Clearance (WHIMAS) Study for Identification of Novel 7T Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease: Protocol for a Cross-Sectional Study

Jasmin Annica Kuhn-Keller, Ingmar Eiling, Lydiane Hirschler, Lena Václavů, Marie-Noëlle Witjes-Ané, Marjolein Wijngaarden, Martijn Nagtegaal, Ece Ercan, Nathaly Rius Ottenheim, Marjan van der Elst, Evelien Sohl, Mark A van Buchem, Simon Mooijaart, Matthias JP van Osch, Jeroen de Bresser

JMIR Res Protoc 2025 (Dec 04); 14:e77681

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Enhancing Access to Family Planning Services in Uganda Through Community Health Extension Workers: Protocol for a Pilot Evaluation

Lydia Kabwijamu, Steven Ndugwa Kabwama, Fredrick Makumbi, Roselline Achola, Andrew Tusubira, Sarah Nabukeera, Christine K Nalwadda

JMIR Res Protoc 2025 (Dec 04); 14:e81627

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Prevalence of Metabolic Syndrome and Noncommunicable Disease Risk Factors in Andaman and Nicobar Islands, India, and Their Association With Ayurvedic Psychosomatic Constitution (Prakriti) and Socioeconomic Status: Protocol for a Cross-Sectional Study

Akashlal M, Azeem Ahmad, Abhayadev A, Lisha S Raj, Manisha M, Arunabh Tripathi, Saroj Kumar Debnath, Bhogavalli Chandra Sekhara Rao, Narayanam Srikanth, Rabinarayan Acharya

JMIR Res Protoc 2025 (Dec 04); 14:e81329

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Newly Designed Optical Coherence Tomography Catheter for Optimizing Bladder Cancer Diagnosis and Treatment: Protocol for a Feasibility Study

Marinka Jolinde Remmelink, Jakko A Nieuwenhuijzen, Daniel Martijn de Bruin, Jorg R Oddens

JMIR Res Protoc 2025 (Dec 02); 14:e76644

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Prevalence and Factors Associated With Depression Among Antenatal and Postnatal Women Attending Government Health Clinics in Selangor, Malaysia: Protocol for a Cross-Sectional Study

Nor Asiah Muhamad, Nur Hasnah Ma'amor, 'Izzah 'Athirah Rosli, Nik Athirah Farhana Nik Azhan, Nurul Hidayah Jamalluddin, Fatin Norhasny Leman, Tengku Puteri Nadiah Tengku Baharudin Shah, Nurul Syazwani Misnan, Noor Harzana Harrun, Norliza Chemi, Norni Abdullah, Nurashikin Ibrahim, Norli Abd Jabbar

JMIR Res Protoc 2025 (Dec 02); 14:e63663

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Patients’ Preferences Regarding Traditional Chinese Medicine for the Treatment of Chronic Obstructive Pulmonary Disease: Protocol for a Mixed Methods Study

Shaonan Liu, Tongtong Wu, Yan Yu, Yingkai Liu, Jing Wang, Xiaoli Chen, Xinfeng Guo

JMIR Res Protoc 2025 (Dec 02); 14:e75426

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An Open-Road Driving Performance Task to Examine Long-Term Medical Marijuana Use and Prescription Opioid Positivity Among Adults Aged 50 Years and Older: Protocol for an Observational Trial

Nicole Ennis, Sherrilene Classen

JMIR Res Protoc 2025 (Nov 28); 14:e77944

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Trust Dynamics and Equity in Public Health in Canada: Protocol for a Mixed Methods Project in the Postpandemic Era

Nazeem Muhajarine, Cory Neudorf, Khatira Mehdiyeva, Fionnuala Braun, Syed Jafar Raza Rizvi, Zili Zhou, Thilina Bandara, Katrina Baudelaire, Sohana Sadique, Daniel A Adeyinka, Sahana Ramamoorthy, Ninan Abraham, Kimberly Huyser, Claire Betker, Mary Jessome, Tamara Chavez, Kim L Lavoie, Ève Dubé

JMIR Res Protoc 2025 (Nov 28); 14:e75199

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Registry of Stroke in Korean Medicine Hospital (RoS-KoMH): Protocol for a Prospective, Multicenter, Observational Study

Han-Gyul Lee, Woo-Sang Jung, Seungwon Kwon, Sangkwan Lee, Cheol-Hyun Kim, Dong-jun Choi, In Lee, Sang-Kwan Moon

JMIR Res Protoc 2025 (Nov 25); 14:e67850

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Registry-Based Assessment of Shunt Operation Methods and Outcomes in Idiopathic Normal Pressure Hydrocephalus (RASHOMON Study): Protocol for a Multicenter Prospective Observational Cohort Study

Eriko Okumura, Kazuhito Takeuchi, Hiroyuki Momota, Tetsuya Nagatani, Toshiaki Taoka, Yuri Aimi, Atsushi Hashizume, Masaki Okazaki, Ryuta Saito

JMIR Res Protoc 2025 (Nov 21); 14:e80678

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Air Pollution Impact on Pregnancy and Early Childhood Development (APiPED) in India: Protocol for a Cohort Study

Harshal Ramesh Salve, Sagnik Dey, Yashika Arora, Surbhi Kapoor, Santu Ghosh, Rakesh Kumar, Sheffali Gulati, Rajesh Sagar, Sudip Kumar Datta, Anand Krishnan

JMIR Res Protoc 2025 (Nov 11); 14:e72683

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Gait Rehabilitation Using Hybrid Assistive Limb in Patients With Lower Limb Amputation: Protocol for a Single-Arm Clinical Trial

Makoto Asaeda, Naoya Orita, Masashi Shimada, Yoshifumi Kono, Kiyo Ueda, Takeya Araki, Naoto Fujita, Yukio Mikami

JMIR Res Protoc 2025 (Nov 11); 14:e76509

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Life Course Trajectories for Young Pasifika in Aotearoa: Protocol for the 25-Year Follow-Up of the Pacific Islands Families Study Cohort

El-Shadan Tautolo, Tugce Bakir-Demir, Shabnam Jalili-Moghaddam, Faasisila Savila, Jesse Kokaua, Philip J Schluter, Maulupeivao Betty Ofe-Grant, Elaine Rush, Jalal Mohammed, Sione Vaka, Jemaima Tiatia-Siau, Radilaite Cammock, Braden Te Ao, Jacinta Fa'alili-Fidow, 'Ilaisaane M E Fifita, Sam Manuela, Leon Iusitini

JMIR Res Protoc 2025 (Nov 10); 14:e77460

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