Effects of Supplementation With Genistein on the Progression of Cognitive Decline in Patients With Mild Cognitive Impairment Due to Alzheimer Disease: Protocol for a Randomized Controlled Trial

Francisco Javier López Román   ^{1, 2 *} , MD, PhD ;   Manuel Sebastián   ³ , PhD ;   Silvia Pérez-Piñero   ³ , PhD ;   Ingrid Hernández-Manzano   ^{1 *} , MPGS ;   Olga Laosa-Zafra   ⁴ , MD, PhD ;   Leocadio Rodríguez-Mañas   ^{4, 5} , MD, PhD ;   Francisco José Tarazona-Santabalbina   ^{6, 7} , MD, PhD ;   Consuelo Borrás   ⁸ , PhD ;   José Viña   ^{8, 9} , MD, PhD

¹ Department of Exercise Physiology, Faculty of Medicine, Universidad Católica de Murcia, Murcia, Spain

² Primary Care Research Group, Instituto Murciano de Investigación Biosanitaria, Murcia, Spain

³ Faculty of Medicine, Universidad Católica de Murcia, Guadalupe (Murcia), Spain

⁴ Foundation for Biomedical Research, Hospital Universitario de Getafe, Madrid, Spain

⁵ Department of Geriatrics, Hospital Universitario de Getafe, Madrid, Spain

⁶ Spanish Society of Geriatrics and Gerontology (SEGG), Madrid, Spain

⁷ Hospital de La Ribera, Alzira, Spain

⁸ Department of Physiology, Faculty of Medicine, Universitat de València, València, Spain

⁹ Department of Geroscience, Universidad Católica de Murcia, Murcia, Spain

*these authors contributed equally