A Stepped Care, Peer-Delivered Intervention to Improve Substance Use and HIV Medication Adherence in Primary Care in South Africa (Project Khanya): Protocol for a Hybrid Type 2 Effectiveness-Implementation Randomized Controlled Trial

Jessica F Magidson   ^{1, 2} , PhD ;   Abigail C Hines   ² , MPH ;   Sybil Hlombekazi Majokweni   ³ , MPH ;   Lwandile Tokwe   ³ , RN, PhD ;   Bronwyn Myers   ^{4, 5, 6} , PhD ;   Stefani Du Toit   ⁷ , PhD ;   Kristen Regenauer   ^{1, 8} , PhD ;   Lena S Andersen   ^{3, 9} , PhD ;   Warren Burnhams   ¹⁰ , MA ;   Catherine Orrell   ^{11, 12} , PhD ;   Sean M Murphy   ¹³ , PhD ;   Goodman Sibeko   ¹⁴ , PhD ;   Noah Triplett   ¹ , PhD ;   Esonasethu Ndwandwa   ³ , MA ;   Neliswa Naledi Kotelo   ³ , BA ;   Tianzhou Ma   ¹⁵ , PhD ;   Steven Safren   ¹⁶ , PhD ;   John Joska   ³ , PhD

¹ Department of Psychology, University of Maryland, College Park, College Park, MD, United States

² Center for Substance Use, Addiction and Health Research (CESAR), University of Maryland, College Park, College Park, MD, United States

³ HIV Mental Health Research Unit, Division of Neuropsychiatry, Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town, Western Cape, South Africa

⁴ Curtin enAble Institute, Faculty of Health Sciences, Curtin University, Bentley, Western Australia, Australia

⁵ Mental Health, Alcohol, Substance Use, and Tobacco Research Unit, South African Medical Research Council, Cape Town, Western Cape, South Africa

⁶ West Australian Country Health Service and Curtin University Research and Innovation Alliance, Perth, Western Australia, Australia

⁷ Institute for Life Course Health Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, Western Cape, South Africa

⁸ Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

⁹ Global Health Section, Department of Public Health, University of Copenhagen, Copenhagen, Denmark

¹⁰ City of Cape Town Health and Substance Abuse, Cape Town, Western Cape, South Africa

¹¹ HIV and Other Infectious Diseases Unit, South African Medical Research Council, Cape Town, Western Cape, South Africa

¹² Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, Western Cape, South Africa

¹³ Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States

¹⁴ Division of Addiction Psychiatry, Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town, Western Cape, South Africa

¹⁵ Department of Epidemiology and Biostatistics, University of Maryland, College Park, Maryland, MD, United States

¹⁶ Department of Psychology, University of Miami, Miami, FL, United States