[¹⁷⁷Lu]Lu-DOTATATE Molecular Radiotherapy During Induction Chemotherapy for First-Line Stage 4 High-Risk Neuroblastoma in South African Children: Protocol for a Phase 1 Randomized Controlled Trial (LuDO-SA Trial)

Jaques van Heerden   ^{1, 2 *} , MD, PhD ;   Mariana Kruger   ^{1, 3 *} , MD, PhD ;   Kershinee Reddy   ^{4, 5 *} , MD, MMed ;   Anel van Zyl   ^{1 *} , MD, PhD ;   James Warwick   ^{6 *} , MD, PhD ;   Celeste Burger   ^{6 *} , MD, MMed ;   Tumelo Moalosi   ^{6 *} , MSc ;   Christoffel van Reenen   ^{6 *} , MSc ;   Alan Davidson   ^{7 *} , MD, M Phil ;   Khanyisile Hlongwa   ^{8 *} , MD, MMed ;   Daniella Violante   ^{8, 9 *} , MSc ;   Nanette Bruwer   ^{6 *} , MSc ;   Gita Naidu   ^{10 *} , MD, PhD ;   Biance Rowe   ^{10 *} , MD, MMed ;   Lizette Louw   ^{11 *} , MD, MMed ;   Bronwin van Wyk   ^{12 *} , PhD ;   Mariza Vorster   ^{13 *} , MD, PhD ;   Thokozani Mkhize   ^{13 *} , MSc ;   Anita Brink   ^{14 *} , MD, PhD

¹ Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Tygerberg Hospital, Stellenbosch University, Cape Town, Western Cape, South Africa

² Department of Paediatric Haemato-Oncology, MIPRO laboratory, Antwerp University Hospital, University of Antwerp, Antwerp Province, Belgium

³ School of Psychology, University of KwaZulu-Natal, Pietermaritzburg, KwaZulu-Natal, South Africa

⁴ Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp Province, Belgium

⁵ Department of Paediatric Haemato-Oncology, Department of Paediatrics and Child Health, Inkosi Albert Luthuli Central Hospital, University of Kwa-Zulu Natal, Durban, KwaZulu-Natal, South Africa

⁶ Department of Nuclear Medicine, Faculty of Medicine and Health Sciences, Tygerberg Hospital, Stellenbosch University, Cape Town, Western Cape, South Africa

⁷ Division of Paediatric Haematology and Oncology, Red Cross War Memorial Children’s Hospital, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, Western Cape, South Africa

⁸ Division of Nuclear Medicine, Red Cross War Memorial Children’s Hospital, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, Western Cape, South Africa

⁹ Department of Nuclear Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, Western Cape, South Africa

¹⁰ Department of Paediatric Haemato-Oncology, Department of Paediatrics and Child Health, University of the Witwatersrand, Chris Hani Baragwanath Academic Hospital, Johannesburg, Gauteng, South Africa

¹¹ Center of Molecular Imaging and Theranostics, Johannesburg, Gauteng, South Africa

¹² Department of Medical Physics, Dr George Mukhari Academic Hospital, Sefako Makgatho University, Ga-Rankuwa, Gauteng, South Africa

¹³ Department of Nuclear Medicine, Inkosi Albert Luthuli Central Hospital, University of KwaZulu Natal, Durban, Kwa-Zulu Natal, South Africa

¹⁴ Nuclear Medicine and Diagnostic Imaging Section, Division of Human of Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria

*all authors contributed equally