Efficacy of Ayurveda Regimen as an Adjunct to Hydroxyurea in Sickle Cell Disease: Protocol for a Prospective, Randomized, Open-Label, Blinded End Point Exploratory Study

Danish Javed   ¹ , BAMS, MS, PhD ;   Amit Kumar Rai   ² , BAMS, MD ;   Sachin Bansal   ³ , MBBS, MD, DM, PDCC ;   Babita Yadav   ⁴ , BAMS, MD ;   Manisha Shrivastava   ⁵ , MBBS, MD ;   Garima Goel   ⁶ , MBBS, MD ;   Ashok Kumar   ⁷ , PhD ;   Sanjeev Kumar   ⁸ , MBBS, MD ;   Azeem Ahmad   ⁹ , BAMS, MD ;   Richa Singhal   ¹⁰ , BAMS, MD ;   Bhagwan S Sharma   ⁹ , BAMS, MD ;   Anil Mangal   ¹¹ , BAMS, MD ;   Bhogavalli Chandrasekhararao   ⁹ , BAMS, MD ;   Narayanam Srikanth   ⁹ , BAMS, MD ;   Rabinarayan Acharya   ⁹ , BAMS, MD, PhD

¹ Department of Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homoeopathy, All India Institute of Medical Sciences Bhopal, Bhopal, Madhya Pradesh, India

² Department of Kayachikitsa, Ayurvedic and Unani Tibbia College and Hospital, Government of National Capital Territory of Delhi, New Delhi, India

³ Department of Medical Oncology and Hematology, All India Institute of Medical Sciences Bhopal, Bhopal, Madhya Pradesh, India

⁴ Department of Clinical Research, Central Ayurveda Research Institute, New Delhi, India

⁵ Bhopal Memorial Hospital & Research Centre, Bhopal, Madhya Pradesh, India

⁶ Department of Pathology and Lab Medicine, All India Institute of Medical Sciences Bhopal, Bhopal, Madhya Pradesh, India

⁷ Department of Biochemistry, All India Institute of Medical Sciences Bhopal, Bhopal, Madhya Pradesh, India

⁸ Department of Community and Family Medicine, All India Institute of Medical Sciences Bhopal, Bhopal, Madhya Pradesh, India

⁹ Department of Ayurveda, Central Council for Research in Ayurvedic Science, Ministry of Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homoeopathy, Government of India, New Delhi, India

¹⁰ National Institute of Malaria Research, New Delhi, India

¹¹ Department of Clinical Research, Regional Ayurveda Research Institute, Gwalior, Madhya Pradesh, India