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This paper is in the following e-collection/theme issue:

RCTs - Protocols/Proposals (non-eHealth) (969) Cost-Effectiveness and Economics (518) Adverse Drug Events Detection, Pharmacovigilance and Surveillance (284) Safety and Error Prevention in Health (333) Smoking Cessation (703) Pharmacovigilance (254) Medication Adherence (178)

Published on in Vol 15 (2026)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/76815, first published .
Person breaking a cigarette in half, symbolizing quitting smoking.

Efficacy, Safety, and Economic Impact of Cytisinicline Maintenance Therapy in Patients Who Are Candidates for Smoking Cessation: Protocol for a Phase IV, Multicenter, Randomized, Open-Label, Controlled, Parallel Clinical Trial (CITISILONG Trial)

Efficacy, Safety, and Economic Impact of Cytisinicline Maintenance Therapy in Patients Who Are Candidates for Smoking Cessation: Protocol for a Phase IV, Multicenter, Randomized, Open-Label, Controlled, Parallel Clinical Trial (CITISILONG Trial)

Authors of this article:

Carlos Rabade Castedo1, 2 Author Orcid Image ;   Ana Estany-Gestal3 Author Orcid Image ;   Carlos A Jiménez Ruiz4 Author Orcid Image ;   José Ignacio de Granda-Orive5, 6 Author Orcid Image ;   Juan Antonio Riesco-Miranda7, 8, 9 Author Orcid Image ;   María Isabel Cristóbal Fernández4 Author Orcid Image ;   Angela Ramos-Pinedo10 Author Orcid Image ;   Jaime Signes-Costa Miñana11, 12 Author Orcid Image ;   María Inmaculada Gorordo-Unzueta13, 14 Author Orcid Image ;   Agustin Valido-Morales15 Author Orcid Image ;   Jacobo Sellarés -Torres16 Author Orcid Image ;   Eva Cabrera-César17 Author Orcid Image ;   Alejandro Frino-García16 Author Orcid Image ;   Luis Valdés Cuadrado1, 2, 18 Author Orcid Image
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Journals

  1. Bieniasz L, Wróblewski K, Kamizela A, Szyszkowska A, Grzegorzewski W, Czerniecka-Kubicka A. Cytisine—New Challenges of a Well-Known Drug in the Treatment of Nicotine Addiction. Journal of Clinical Medicine 2026;15(8):3146 View
  2. Jimenez-Ruiz C, Cristóbal Fernández M, de Granda-Orive J, Ramos-Pinedo A, Rábade-Castedo C, Carrion-Valero F, Gorordo-Unzueta I, Riesco-Miranda J. Future Treatments for Tobacco Dependence. Open Respiratory Archives 2027;9:100668 View