Surveillance of the Genetic Signature in Circulating Tumor DNA for Guiding Adjuvant Chemotherapy in Urothelial Carcinoma: Protocol for a Pilot Randomized Controlled Trial

Yongle Zhan   ^{1 *} , PhD ;   Xiaohao Ruan   ^{2 *} , MD ;   Yishuo Wu   ^{3 *} , MD ;   Tsun Tsun Stacia Chun   ¹ , BSc ;   Chi Yao   ¹ , MM ;   Ruofan Shi   ² , MD ;   Jiacheng Liu   ² , MD ;   Salida Ali   ¹ , BSc ;   Ruochen Ma   ¹ , MSc ;   Da Huang   ² , MD ;   Yi Gao   ² , PhD ;   Ying Xu   ² , MM ;   Lu Chen   ² , PhD ;   Qijun Du   ⁴ , MD ;   Ada Tsui-Lin Ng   ⁵ , MBBS ;   Cho Wing Bryan Li   ⁶ , MBBS ;   Danfeng Xu   ² , MD ;   Rong Na   ¹ , MD

¹ Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China (Hong Kong)

² Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

³ Department of Urology, Huashan Hospital, Fudan University, Shanghai, China

⁴ Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China (Hong Kong)

⁵ Division of Urology, Department of Surgery, Queen Mary Hospital, Hong Kong, China (Hong Kong)

⁶ Department of Medicine, Queen Mary Hospital, Hong Kong, China (Hong Kong)

*these authors contributed equally