Metabolic Flexibility to Predict Lifestyle Interventions Outcomes (MEPHISTO): Protocol for Predictive Validation Study and Randomized Controlled Trial

Monika Ludlova   ^{1 *} , MSc ;   Kateřina Koudelková   ^{2 *} , MD ;   Jitka Pallova   ^{2 *} , MD ;   Barbora Koudelkova   ^{2 *} , BS ;   Michaela Siklova   ^{3 *} , ING, PhD ;   Monika Cahova   ^{4 *} , RNDr, PhD ;   Tomas Vetrovsky   ^{1 *} , MD, PhD ;   Michal Steffl   ^{5 *} , PhD ;   Jan Gojda   ^{2 *} , MD, PhD

¹ Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic

² Clinical Research Department, Kralovske Vinohrady University Hospital and Third Faculty of Medicine, Charles University, Prague, Czech Republic

³ Department of Pathophysiology, Centre for Research on Diabetes, Metabolism and Nutrition, Third Faculty of Medicine, Charles University, Prague, Czech Republic

⁴ First Faculty of Medicine, Institute of Clinical and Experimental Medicine, Prague, Czech Republic

⁵ Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic

*all authors contributed equally