TheraSphere Yttrium-90 Glass Microspheres Combined With Chemotherapy Versus Chemotherapy Alone in Second-Line Treatment of Patients With Metastatic Colorectal Carcinoma of the Liver: Protocol for the EPOCH Phase 3 Randomized Clinical Trial

Nikhil Chauhan   ¹ , PhD ;   Mary F Mulcahy   ² , MD ;   Riad Salem   ^{2, 3, 4} , MD, MBA ;   Al B Benson III   ^{2, 5} , MD, FACP, FASCO ;   Eveline Boucher   ¹ , MD ;   Janet Bukovcan   ¹ , BSc (Hons) ;   David Cosgrove   ⁶ , MD ;   Chantal Laframboise   ¹ , BScN ;   Robert J Lewandowski   ^{2, 3, 4} , MD, FSIR ;   Fayaz Master   ¹ , BSc ;   Bassel El-Rayes   ^{7, 8} , MD ;   Jonathan R Strosberg   ⁹ , MD ;   Daniel Y Sze   ¹⁰ , MD, PhD ;   Ricky A Sharma   ¹¹ , MA, PhD, MB BChir, FRCP, FRCR

¹ Research and Development, BTG International group companies, London, GB

² Division of Hematology and Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, US

³ Section of Interventional Radiology, Department of Radiology, Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, US

⁴ Division of Transplant Surgery, Department of Surgery, Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, US

⁵ Northwestern Medical Group, Feinberg School of Medicine, Northwestern Memorial Hospital, Chicago, IL, US

⁶ Division of Medical Oncology, Vancouver Cancer Center, Compass Oncology, Vancouver, WA, US

⁷ Winship Cancer Institute, Emory University, Atlanta, GA, US

⁸ Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, US

⁹ H Lee Moffitt Cancer Center, Tampa, FL, US

¹⁰ Interventional Radiology, Stanford University Medical Center, Stanford, CA, US

¹¹ National Institute for Health Research University College London Hospitals Biomedical Research Centre, UCL Cancer Institute, London, GB