Evaluation of Biological and Functional Changes in Healthy Smokers Switching to the Tobacco Heating System 2.2 Versus Continued Tobacco Smoking: Protocol for a Randomized, Controlled, Multicenter Study

S Michael Ansari   ^{1 *} , BS ;   Nicola Lama   ^{1 *} , PhD ;   Nicolas Blanc   ^{1 *} , MD ;   Marija Bosilkovska   ^{1 *} , PharmD ;   Andrea Donelli   ¹ , MSc ;   Patrick Picavet   ¹ , MD ;   Gizelle Baker   ¹ , PhD ;   Christelle Haziza   ^{1 *} , PhD ;   Frank Lüdicke   ^{1 *} , MD

¹ Philip Morris International Research & Development, 2000 Neuchâtel, Switzerland

*these authors contributed equally