Symptomatic Treatment of Vascular Cognitive Impairment (STREAM-VCI): Protocol for a Cross-Over Trial

Jolien Fleur Leijenaar   ¹ , MD, MSc ;   Geert Jan Groeneveld   ^{1, 2} , MD, PhD ;   Wiesje Maria van der Flier   ^{1, 3} , PhD ;   Philip Scheltens   ¹ , MD, PhD ;   Erica Surya Klaassen   ² , MSc ;   Henry Chanoch Weinstein   ⁴ , MD, PhD ;   Geert Jan Biessels   ⁵ , MD, PhD ;   Frederik Barkhof   ^{6, 7} , MD, PhD ;   Niels Daniël Prins   ^{1, 8} , MD, PhD

¹ Alzheimer Center & Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands

² Centre for Human Drug Research, Leiden, The Netherlands

³ Department of Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, The Netherlands

⁴ Department of Neurology, Onze Lieve Vrouwe Gasthuis West, Amsterdam, The Netherlands

⁵ Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands

⁶ Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands

⁷ Institutes of Neurology and Healthcare Engineering, University College London, London, United Kingdom

⁸ Brain Research Center, Amsterdam, The Netherlands