This paper is in the following e-collection/theme issue:

RCTs - Protocols/Proposals (funded, already peer-reviewed, non-eHealth) (144) Malaria Surveillance and Prevention (20)

Published on in Vol 5 , No 4 (2016) :Oct-Dec

Efficacy and Safety of High-Dose Ivermectin for Reducing Malaria Transmission (IVERMAL): Protocol for a Double-Blind, Randomized, Placebo-Controlled, Dose-Finding Trial in Western Kenya

Efficacy and Safety of High-Dose Ivermectin for Reducing Malaria Transmission (IVERMAL): Protocol for a Double-Blind, Randomized, Placebo-Controlled, Dose-Finding Trial in Western Kenya

Efficacy and Safety of High-Dose Ivermectin for Reducing Malaria Transmission (IVERMAL): Protocol for a Double-Blind, Randomized, Placebo-Controlled, Dose-Finding Trial in Western Kenya

Authors of this article:

Menno R Smit 1 Author Orcid Image ;   Eric Ochomo 2 Author Orcid Image ;   Ghaith Aljayyoussi 1 Author Orcid Image ;   Titus Kwambai 2, 3 Author Orcid Image ;   Bernard Abong'o 2 Author Orcid Image ;   Nabie Bayoh 4 Author Orcid Image ;   John Gimnig 4 Author Orcid Image ;   Aaron Samuels 4 Author Orcid Image ;   Meghna Desai 4 Author Orcid Image ;   Penelope A Phillips-Howard 1 Author Orcid Image ;   Simon Kariuki 2 Author Orcid Image ;   Duolao Wang 1 Author Orcid Image ;   Steve Ward 1 Author Orcid Image ;   Feiko O ter Kuile 1 Author Orcid Image
Article Authors Cited by (18) Tweetations (96) Metrics

Journals

  1. El-Saber Batiha G, Alqahtani A, Ilesanmi O, Saati A, El-Mleeh A, Hetta H, Magdy Beshbishy A. Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects. Pharmaceuticals 2020;13(8):196 View
  2. Dabira E, Soumare H, Lindsay S, Conteh B, Ceesay F, Bradley J, Kositz C, Broekhuizen H, Kandeh B, Fehr A, Nieto-Sanchez C, Ribera J, Peeters Grietens K, Smit M, Drakeley C, Bousema T, Achan J, D’Alessandro U. Mass Drug Administration With High-Dose Ivermectin and Dihydroartemisinin-Piperaquine for Malaria Elimination in an Area of Low Transmission With High Coverage of Malaria Control Interventions: Protocol for the MASSIV Cluster Randomized Clinical Trial. JMIR Research Protocols 2020;9(11):e20904 View
  3. Smit M, Ochomo E, Aljayyoussi G, Kwambai T, Abong'o B, Chen T, Bousema T, Slater H, Waterhouse D, Bayoh N, Gimnig J, Samuels A, Desai M, Phillips-Howard P, Kariuki S, Wang D, Ward S, ter Kuile F. Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial. The Lancet Infectious Diseases 2018;18(6):615 View
  4. Chaccour C, Hammann F, Rabinovich N. Ivermectin to reduce malaria transmission I. Pharmacokinetic and pharmacodynamic considerations regarding efficacy and safety. Malaria Journal 2017;16(1) View
  5. Chaccour C, Hammann F, Alustiza M, Castejon S, Tarimo B, Abizanda G, Irigoyen Barrio Á, Martí Soler H, Moncada R, Bilbao J, Aldaz A, Maia M, Del Pozo J. Cytochrome P450/ABC transporter inhibition simultaneously enhances ivermectin pharmacokinetics in the mammal host and pharmacodynamics in Anopheles gambiae. Scientific Reports 2017;7(1) View
  6. Kobylinski K, Ubalee R, Ponlawat A, Nitatsukprasert C, Phasomkulsolsil S, Wattanakul T, Tarning J, Na-Bangchang K, McCardle P, Davidson S, Richardson J. Ivermectin susceptibility and sporontocidal effect in Greater Mekong Subregion Anopheles. Malaria Journal 2017;16(1) View
  7. Kobylinski K, Escobedo-Vargas K, López-Sifuentes V, Durand S, Smith E, Baldeviano G, Gerbasi R, Ballard S, Stoops C, Vásquez G. Ivermectin susceptibility, sporontocidal effect, and inhibition of time to re-feed in the Amazonian malaria vector Anopheles darlingi. Malaria Journal 2017;16(1) View
  8. al Jalali V, Zeitlinger M. Systemic and Target-Site Pharmacokinetics of Antiparasitic Agents. Clinical Pharmacokinetics 2020;59(7):827 View
  9. Smit M, Ochomo E, Waterhouse D, Kwambai T, Abong'o B, Bousema T, Bayoh N, Gimnig J, Samuels A, Desai M, Phillips‐Howard P, Kariuki S, Wang D, ter Kuile F, Ward S, Aljayyoussi G. Pharmacokinetics‐Pharmacodynamics of High‐Dose Ivermectin with Dihydroartemisinin‐Piperaquine on Mosquitocidal Activity and QT ‐Prolongation ( IVERMAL ). Clinical Pharmacology & Therapeutics 2019;105(2):388 View
  10. Smit M, Ochomo E, Aljayyoussi G, Kwambai T, Abong’o B, Bousema T, Waterhouse D, Bayoh N, Gimnig J, Samuels A, Desai M, Phillips-Howard P, Kariuki S, Wang D, Ward S, ter Kuile F. Human Direct Skin Feeding Versus Membrane Feeding to Assess the Mosquitocidal Efficacy of High-Dose Ivermectin (IVERMAL Trial). Clinical Infectious Diseases 2019;69(7):1112 View
  11. Muñoz J, Ballester M, Antonijoan R, Gich I, Rodríguez M, Colli E, Gold S, Krolewiecki A, Prichard R. Safety and pharmacokinetic profile of fixed-dose ivermectin with an innovative 18mg tablet in healthy adult volunteers. PLOS Neglected Tropical Diseases 2018;12(1):e0006020 View
  12. Scheim D. From Cold to Killer: How SARS-CoV-2 Evolved without Hemagglutinin Esterase to Agglutinate, Then Clot Blood Cells in Pulmonary and Systemic Microvasculature. SSRN Electronic Journal 2020 View
  13. Pessanha de Carvalho L, Kreidenweiss A, Held J. Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial Action. Molecules 2021;26(8):2304 View
  14. Kositz C, Bradley J, Hutchins H, Last A, D'Alessandro U, Marks M. Broadening the range of use cases for ivermectin – a review of the evidence. Transactions of The Royal Society of Tropical Medicine and Hygiene 2022;116(3):201 View
  15. Singh A, Sheth P, Dhaneria S, Gupta D. Efficacy and safety of ivermectin for COVID-19: A systematic review and meta-analysis. Asian Pacific Journal of Tropical Medicine 2021;14(10):440 View
  16. Mathachan S, Sardana K, Khurana A. Current use of ivermectin in dermatology, tropical medicine, and COVID-19: An update on pharmacology, uses, proven and varied proposed mechanistic action. Indian Dermatology Online Journal 2021;12(4):500 View

Books/Policy Documents

  1. D’Alessandro U. Towards Malaria Elimination - A Leap Forward. View