Background: Asthma is the most common chronic condition in children. For many, the disease is inadequately controlled, which can burden the lives of children and their families as well as the health care system. Improved use of the best available scientific evidence by primary care practitioners could reduce the need for hospital care and improve quality of life and asthma control, thereby reducing overall costs to society and families.
Objective: The Primary Care Pathway for Childhood Asthma aims to improve the management of children with asthma by (1) providing primary care practitioners with an electronic guide (a clinical pathway) incorporated into the patient’s electronic medical record, and (2) providing train-the-trainer education to chronic disease management health professionals to promote the provision of asthma education in primary care.
Methods: The research will utilize a pragmatic cluster-controlled design, quantitative and qualitative research methodologies, and economic evaluation to assess the implementation of a pathway and education intervention in primary care. The intervention will be analyzed for effectiveness, and if the results are positive, a strategy will be developed to implement delivery to all primary care practices in Alberta.
Results: The research has been successfully funded and ethics approvals have been obtained. Practice recruitment began fall 2015, and we expect all study-related activities to be concluded by March 2018.
Conclusions: The proposed pathway and education intervention has the potential to improve pediatric asthma management in Alberta. The intervention is anticipated to result in better quality of care for equal or lesser cost.
ClinicalTrial: ClinicalTrials.gov NCT02481037; https://clinicaltrials.gov/ct2/show/NCT02481037 (Archived by WebCite at http://www.webcitation.org/6fPIQ02Ma).
Background and Overview
Asthma is the most common chronic disease of childhood [- ]. At least 15% of Canadian children are affected by this disease, and over 50% of these cases are poorly controlled [ - ]. Asthma is among the top 10 reasons for Albertan children to visit an emergency department and the top 5 reasons for urgent admissions to hospital [ , ]. As compared with healthy children, children with asthma miss three times as many school days [ , ] and have substantially reduced quality of life [ , ]. From a societal perspective, inadequate asthma control also presents a considerable economic burden due to the costs associated with hospital and emergency department admissions, medications, and caregiver productivity losses [ ].
High-quality evidence exists regarding how to best manage childhood asthma in a primary care setting to optimize control and minimize acute disease exacerbations [- ]. The best treatment varies depending on the child’s asthma disease phenotype, of which there are broadly two types. Although the terms used vary, we refer to these types as “persistent/seasonal disease” and “intermittent/viral triggered” [ - ]. Persistent/seasonal disease has continuous symptoms and is often triggered by allergens, exercise, cold air, and viral illnesses, whereas intermittent/viral-triggered disease is predominately provoked by viral upper respiratory tract infections and resolves completely between infections. For most children with persistent/seasonal disease, inhaled corticosteroids substantially reduce ongoing symptoms, bronchodilator use, asthma exacerbations, and health care utilization [ - ]. For children with intermittent/viral-triggered disease, montelukast (Singulair) has been shown to substantially reduce wheezing exacerbations, asthma symptoms, and health care utilization [ - ].
Although some studies have demonstrated methods to optimize asthma outcomes and minimize costs, this does not guarantee that patients actually receive the best care. It is estimated that across the spectrum of health care, 30-40% of patients do not receive treatments of proven effectiveness [, ]. Studies from the United States have shown that primary care practitioners do not use preventive medications in up to 45% of children with asthma [ , ], and unpublished data (2008-2011) reported by Alberta Health Services (AHS) from Alberta pharmacies show that about 50% of children with asthma who are treated with rescue beta-agonists do not also receive preventative medications [ ].
Clinical pathways are a common strategy for changing professional behavior and improving the quality of care delivery, reducing practice variation, and reducing costs of health care [- ]. Although relatively few published studies have rigorously evaluated the impact of clinical pathways on clinical outcomes and costs [ ], it is widely recognized that the rigor involved in pathway development and assessment of evidence obtained is important to improving outcomes. Accordingly, many health organizations such as AHS are using clinical pathways with this intent. In support of this approach, a clinical pathway focused on the emergency management of childhood asthma has been shown to increase the use of evidenced-based therapies [ , ]. However, creation of clinical pathways (or guidelines) is not enough; active implementation strategies are needed to achieve optimal improvements in outcomes [ - ]. Two strategies that are among the most consistently successful for changing practitioner behavior and improving patient outcomes are interactive educational sessions and reminder systems [ - ].
Even if children are prescribed appropriate medications, parents frequently do not receive adequate information and education to understand the rationale and importance of using preventive medications, which often results in poor adherence [- ]. Adherence refers to a patient successfully taking medication. Primary adherence refers to the obtaining of medication prescribed, and secondary adherence refers to proper completion of the regime as intended by the prescriber. A World Health Organization [ ] review indicated 30% adherence to medications by children and adolescents with asthma, which is among the lowest reported for any chronic disease. There is good evidence, however, that asthma education programs for children with severe exacerbations requiring emergency department and in-hospital care sufficiently improve adherence to reduce subsequent hospitalizations, emergency department visits, and urgent disease-related physician visits by 20-30% [ ].
We propose to improve the prescription and use of evidenced-based preventative therapies for children with asthma, with the goal to significantly improve their disease control and quality of life, and reduce unnecessary emergency department visits and hospitalizations by 20% each. We will achieve this by (1) installing a primary care clinical pathway for managing childhood asthma into clinicians’ electronic medical record (EMR) to facilitate the use of best evidence by practitioners, and (2) training chronic disease management (CDM) health professionals to provide targeted and timely asthma education to parents and children with asthma. We will test this pathway and education project in a representative sample of 22 Alberta primary care practices, using a pragmatic cluster-controlled trial methodology. Specifically, we will determine if our proposed innovation, as compared with usual care,...
- ...increases prescription of evidenced-based preventative therapies;
- ...increases dispensing (primary adherence) of evidenced-based preventative therapies;
- ...improves children’s asthma control;
- ...improves quality of life for children and families; and
- ...decreases health care utilization (emergent primary care visits, emergency department visits, and hospitalizations) for asthma, and decreases overall societal (health system and family) costs.
In Spring 2011, the AHS Respiratory Network—now formally known as the “Respiratory Health Strategic Clinical Network (RHSCN)”—adopted the childhood asthma pathway initiative, in collaboration with the AHS child health community, as one of its 3 top priorities and provided human and financial resources to move the pathway initiative forward. The initial project of the RHSCN and our project team was to develop, implement, and evaluate emergency department and in-patient pathways, for which we received the Canadian Institutes of Health Research Partnerships for Health System Improvement funding. Concurrently, with the start of the emergency department/in-patient pilot project and the ongoing implementation of the emergency department and in-patient pathways across the province, the RHSCN started developing the primary care pathway.
In Fall 2013, our team developed a collaboration with the Health Quality Council of Alberta (HQCA) who have agreed to extract, link, and analyze health administrative data (which they routinely receive and utilize) and other data provided to them from 2 Albertan community-based primary care research networks (Northern and Southern Alberta Primary Care Research Networks—NAPCReN  and SAPCReN, respectively ). These networks are regional networks contributing to the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) [ ]. CPCSSN extracts clinical data quarterly from participating practitioners’ (sentinels) EMRs, cleans them, removes identifiers, and makes these data available for surveillance, epidemiology, and health services research. With the principal investigator (AC), CPCSSN is currently developing and validating a case definition and case finding algorithm for childhood asthma, which will be added in due course to its routine data extraction and processing. The networks contributing to CPCSSN in Alberta are currently able to process data from both the Wolf and Med Access EMR systems. These networks have agreed to assist with recruiting practices to participate in this project.
The project team has engaged extensively with frontline primary care practitioners, primary care leaders, and pediatric respirologists and allergists in developing this primary care pathway project over the last 3 years; each of these groups has heavily invested and is committed to the successful completion of our project. We have engaged frontline practitioners in the following ways: (1) being part of an interdisciplinary pathway development committee including primary care and subspecialty care practitioners with rural, regional, and urban representation; (2) conducting a small focus group (consultation) session about the content and format of the pathway with primary care practitioners at Alberta primary care conferences; (3) beta-testing of the EMR-based pathway in 4 primary care practices; and (4) surveying Alberta primary care practitioners for feedback about the pathway, its design, and practicality. The capacity to manage their asthma patients according to the best practice will be enhanced by the integration of the pathway into the EMRs and by the education given to the CDM health professionals. Participating clinics will identify an individual available for the practice who will take on the role of a CDM professional. The CDM professionals will receive a 3-hour training session/updating on asthma education with continued support from the trainer for the duration of the intervention. They will be provided with access to resources that will be available thereafter to ensure sustainability.
Currently, an asthma case definition is being developed, which is an algorithm that screens the CPCSSN data extracted from EMRs to accurately identify patients with asthma. Once developed, the case definition will be validated by comparing it with a gold standard established by 2 experienced physicians using 1000 pediatric CPCSSN records.
Network leadership will encourage their members’ participation in this initiative by introducing the study team to the medical and administrative leads of all their participating practices. Alongside SAPCReN and NAPCReN research staff, study team members will travel to eligible practice sites to inform them about the details of the project, answer any questions they might have, and then ask them to participate in this project.
In this project, the following 4 organizations will each play an essential role: AHS (RHSCN), HQCA, and NAPCReN/SAPCReN. RHSCN and HQCA are committing substantial in-kind funding toward this project over the next 3 years. In addition, 3 other strategic clinical networks, namely, (1) Maternal, Newborn, Child and Youth, (2) Emergency, and (3) Primary Care Chronic Disease Management, share substantial common ground. A total of 3 primary care organizations, the 2 AHS Primary and Community Care portfolios and the Provincial Primary Care Network, will be “end users,” throughout the project, and will also provide critical advice as we plan our “implementation scale and spread” rollout. Participating primary care practices are also end users, providing valuable input into feasibility and sustainability. Finally, the patients of Alberta will be the final stakeholders, as we anticipate their health will be affected favorably.
We propose a 3-year mixed-methods health services research project using a randomized cluster-controlled trial design (with primary care practices as the cluster; trial registration number NCT02481037) to achieve the following objectives:
- To use the Theoretical Domains Framework (TDF) to refine our implementation strategy;
- To implement the intervention (a childhood asthma primary care clinical pathway in EMRs and identifying and training CDM health professionals to provide asthma education) in the 11 practices in the intervention arm;
- To evaluate our project intervention using interviews, health administrative and EMR databases, and child and parent surveys of quality of life, the child’s asthma control, and the socioeconomic burden of the child’s disease on their family; and
- To develop a detailed “scale and spread” strategy if our intervention is shown to be successful (ie, yields either cost savings or improved child and parent quality of life) for all Alberta primary care practices who use a supported EMR.
Intervention Development and Implementation Strategy
The development of our implementation strategy has followed the Knowledge-to-Action Model of Graham and colleagues . This cyclic process starts with the identification of the problem—a knowledge-practice gap in the management of childhood asthma in a primary care setting—followed by synthesis of the evidence into a primary care pathway [ ], assessment of potential barriers to its use, tailoring of known-effective implementation strategies to local circumstances, evaluation to determine whether the problem has improved and feedback of evaluation results to all end users (decision makers and participating practitioners).
The primary care pathway developed over 2 years by a subcommittee of the Asthma Working Group, RHSCN, was geographically representative of Alberta and included primary care practitioners (n=4), asthma educators (n=5), pharmacists (n=1), allergists and respiratory physicians (n=4), and asthma policy decision makers (n=2). This committee critically reviewed existing global and national guidelines [, ] and recent randomized trials and systematic reviews to formulate the pathway. Drafts of the pathway were critically reviewed two times by primary care practitioners for ease of use and relevance to their practice, and revised each time.
The following sections provide a summary of the core components of the intervention to be provided to the intervention arm practices of the study:
Pathway Implementation Strategies
Based on previous extensive experience in implementing clinical pathways [- ] and best evidence available [ , , - ], two change strategies were selected to implement the proposed project: (1) an interactive online learning module to teach primary care practitioners about the evidence for treatment strategies in the clinical pathway, and (2) user-written software installed within practitioners’ EMR that will serve as a reminder system to facilitate improved patient documentation and management. We will also use the results of a study being conducted using the TDF to identify necessary modifications to our strategy for primary care practices randomized to the intervention arm [ ].
Development of EMR Embedded Pathway
The EMR prototype (developed in Med Access and currently being developed in Wolf) provides practitioners with dropdown menus to document key findings from medical history review and physical examination, classify patient’s disease phenotype to generate therapeutic recommendations, assess asthma control, generate a risk assessment, and print out asthma action plans and patient prescriptions.
Development of a Web-Based Interactive Learning Module
To ensure primary care practitioners understand the underlying rationale and evidence behind the development of the primary care pathway, practitioners randomized to the intervention arm will have easy access to a Web-based interactive learning module, which is designed to easily fit into a busy practitioner’s schedule. An equivalent module was developed by the research team and successfully used in a trial of an educational intervention in emergency room and in-patient management in Alberta . Physicians and nurses will access the site with a password and will indicate completed sections before the intervention commences. A well-designed Web-based professional learning module has been shown in a previous trial to be as effective at enhancing learning and changing professional behavior as in-person interactive teaching sessions [ ]. Parents will also be given access to patient-oriented Web modules to enhance the nurse-led teaching.
Train-the-Trainer for Patient Education
CDM health professionals working within the practices in the intervention arm will be provided 3 hours of in-person training on providing asthma education to children with asthma and their families. This training will be provided by the clinical coordinator, an experienced Certified Respiratory Educator (HS).
Practices will be recruited from those who are currently or are becoming a member of the NAPCReN or SAPCReN. All children (1-17 years of age at the time of enrollment) who meet the case definition of asthma (and are seen by a participating primary care practitioner within a consenting practice) will be included in the trial’s analysis unless they refuse consent . The CPCSSNs use a “social contract” consent process, where practice populations are informed generally about research, information is freely available on specific projects, and people are included unless they object [ ]. Because the project will collect data outside the CPCSSN protocol, parents of children with asthma in the participating practices will be sent a letter by their primary practitioner outlining implied consent and asking them to complete surveys about quality of life, asthma control, and the burden (impact) of asthma on their family.
Sample Size Calculation and Analysis
Our AHS partners provided the number of pediatric asthma incidences billed by each practice in the province. We will use this information to select practices that have more than 70 active, eligible asthma patients. In addition, the Primary Care Asthma Working Group of clinicians agreed the minimal clinically important difference to be 20% (seefor a detailed sample size calculation).
Patients included in the analysis of the primary and one of the secondary outcomes (proportion of children dispensed a preventive medication) will be categorized as either “successful” or “not successful” based on the logic outlined in. Given the clustered nature of patients’ “success” within practices, a mixed effects logistic regression model will be performed where clustering is considered. Odds ratios for success between arms will be presented along with 95% CIs. The modeling will include assessment of potential confounders and independent risk factors. To analyze the other secondary outcomes (quality of life and asthma control and emergency department visits/hospitalizations), we will use a linear mixed effects regression model, and include fixed effects for the baseline/follow-up periods, the pathway/control arms, and stratifications/interaction, and random effects to account for clustering in practices.
Randomization of Practices Design Issues and Potential Bias
All practices consenting to participate in this trial will be randomized, stratified for urban (Edmonton/Calgary) versus nonurban and academic (trainees routinely evaluate patients) versus nonacademic practices. A statistician not aware of our project question will allocate practices using a standard randomization software. We have chosen practices as the unit of randomization because most individual practitioners within a shared practice use the same EMR and we wish to prevent contamination. Because we are testing the effectiveness of embedding the pathway into clinicians’ EMR and train-the-trainer CDM professional education, consenting practices randomized to usual care will not have access to either intervention, and therefore the risk of significant contamination is small. In addition, the design provides an opportunity to test for contamination by comparing the difference between the pre- and post-periods for the 2 groups (ie, intervention and control).
Practices will be randomized to either:
- Routine care versus intervention
- Embedding a primary care clinical pathway for managing childhood asthma into clinicians’ EMR to facilitate practitioners utilizing best evidence, and training these practices’ CDM professionals to provide asthma education to children with asthma and their parents.
Data will come from 3 sources, namely, health administrative sets, data extracted from participating practices’ EMR, and surveys of asthma control, quality of life, and socioeconomic factors. Health administrative datasets will include Alberta Patient Registry, emergency department visits (National Ambulatory Care Reporting System), hospitalization abstracts (Discharge Abstract Database), practitioners visits (Alberta physician/NP claims), and pharmacy dispensing (Pharmaceutical Information Network); these datasets are considered to be of good quality with accurate personal identifiers on more than 95% of records. As previously noted, EMR data using a validated case definition will be extracted for all children with asthma meeting the inclusion/exclusion criteria. This will provide individual categorical and continuous patient-level data such as patient demographics, encounter history, medication prescriptions, and comorbid disease. Also as previously noted, the HQCA will play a pivotal role in our trial as they will (1) receive the aforementioned datasets from AHS, Alberta Health, and NAPCReN/SAPCReN; (2) extract and link the necessary data using a separate file from the practitioners, which will contain patients’ CPCSSN identifier linked to their Alberta Health Care Number; (3) perform the planned analysis; and (4) provide the aggregated results to our research team.
Letters from participating practitioners will be sent two times to families of children with asthma before and 11 months after the study intervention starts. The letter will inform parents about the purpose of the survey (though the broad purpose of the project will not be revealed to maintain masking) and will ask the primary parent or caretaker to go online to review the information sheet and complete a socioeconomic survey and the Paediatric Asthma Caregiver’s Quality of Life Questionnaire (PACQLQ) for children with asthma, or to complete written copies of the questionnaires and return them by self-addressed stamped envelopes. A previous study  has validated the PACQLQ for use by parents of children less than 7 years of age. Children 7 years and older will be asked to also complete the Standardised Paediatric Asthma Quality of Life Questionnaire and the Asthma Control Questionnaire [ ]. The socioeconomic survey includes questions such as day care or school days missed, parent work days missed, and asthma medications purchased in the last 30 days, to allow calculation of the economic impact of a child’s asthma on their family.
We will purposefully select 6 practices randomized to the pathway and education intervention based on size of the practice and heterogeneity of professionals in the practice , and evaluate them using multidisciplinary focus groups after the intervention. The interview protocols will be developed following the implementation of the intervention to incorporate key learning from the implementation into the question development. The focus groups will include practitioners and other professionals, for a total of at least six clinicians, and will be recorded by a court reporter [ ]. The content of the interview questions will be guided by the Knowledge to Action Model [ ] and will target areas such as attributes of the pathway, adopters, and implementation setting. Clinicians will have the opportunity to provide feedback regarding potential challenges with the pathway and offer suggestions for improvements.
To monitor the progress and permit follow-up of ideas that emerge from the focus group, data collection and analysis will follow an iterative and concurrent process. The post-implementation focus group data will be analyzed in the following three phases: coding, categorizing, and developing themes . First, data for each practice will be coded to facilitate analysis. The code word(s) will reflect the essence of the data leading to ease of recognition as the number of code words increases. Codes will be operationally defined so that they can be consistently applied throughout the data. Second, codes will be placed into broad categories that correspond to the major unit of analysis. As categories emerge, their theoretical properties will be defined. Third, comparisons between categories will be carried out to locate similarities and differences among them. Data analysis will be carried out using NVivo 10.
The potential for provincial-wide savings is achievable because of the high-quality evidence (numerous randomized controlled trials, systematic reviews, and international consensus guidelines) demonstrating that appropriately tailored anti-inflammatory medications reduce emergency department visits and hospitalizations and that asthma education training targeted to focus on families with children with more severe disease also yields a 20% reduction in subsequent hospitalizations, a 30% reduction in emergency department visits, and a 30% reduction in nonscheduled urgent physician visits for disease exacerbation . Further validating the ability of preventative therapy for asthma to reduce health care utilizations and costs, health services studies in children and adults in both British Columbia and Sweden utilizing administrative data have shown that higher utilization of inhaled corticosteroids is correlated with lower rates of hospitalization and lower overall health care costs [ , ].
The primary analysis will be from the health care system perspective. Total health system costs per child with asthma in the 2 trial arms before and after the intervention will be determined. Health system costs will be disaggregated into the following three parts: (1) those stemming from pathway implementation and train-the-trainer education sessions, 2) those from asthma education provided by CDM professionals, and (3) those from hospitalizations and emergency department and practitioner visits for asthma. Overall health system costs will be considered decreased by the project intervention if the cost decrease from reduced emergent physician visits, emergency department visits, and hospitalization outweighs the cost increase from pathway implementation and asthma education. The impact on costs will be considered alongside the impact on outcomes including quality of life. A secondary analysis will also include consideration of family costs that consist of parent loss of work, travel, or other out-of-pocket costs due the child’s disease.
Costs stemming from health care utilization (drugs, hospitalizations, emergency department, and practitioner visits) will be derived from health administrative data. Actual costs are available from AHS for in-patient stays at Calgary and Edmonton Zone hospitals, and costs for other Alberta hospitals can be approximated using Institute of Health Economics (IHE) provincial estimates . Emergency department visit costs will be determined using the IHE standard provincial estimates [ ]. Surveys of staff and parents of children with asthma from each of the participating practices will provide cost estimates by collecting the following data: time spent on train-the-trainer sessions, staff time to educate families, and family quality of life measures, as well as out-of-pocket expenditures on their child’s disease.
The protocol obtained approval from the Health Research Ethics Board at the University of Alberta (Edmonton, AB) on August 7, 2015, and the Conjoint Health Research Ethics Board at the University of Calgary (Calgary, AB) on September 23, 2015.
Practice recruitment began September 2015, and all study-related activities are expected to conclude March 2018 (seefor a timeline of major objectives) with the following outcomes:
The proportion of symptomatic children with asthma in the baseline and follow-up periods (separate calculations) who are appropriately treated with a preventer will be the primary outcome. The denominator will be the number of children who meet the case definition of asthma and receive at least one prescription for an inhaled short-acting beta-agonist (eg, salbutamol) during the applicable period. The numerator will be, of these children, the number of those who receive a prescription for inhaled corticosteroid, montelukast, a combination of inhaled long-acting beta-agonist and corticosteroid (ie, agonist + corticosteroid), or some combination of these 3 drugs in the same period.
Dispensed Preventative Therapies (Primary Adherence)
The proportion of applicable children in baseline and follow-up periods who are appropriately dispensed a preventer will highlight if there is a significant gap between prescriptions given and filled. The denominator will be the same as for the primary outcome but the numerator will be the number of these children who are dispensed 1 or more preventer medications from newly available PIN data.
Emergency Department Visits and Hospitalizations for Asthma
The number of asthma emergency department visits or hospitalizations for asthma (ICD10 J45 or J46) per child who meets the case definition of asthma during each period will be a measure of health care use.
Electronic Medical Record Data
The CPCSSN and research team will develop and validate a case definition and case finding algorithm for identifying children with asthma in the CPCSSN practices. The CPCSSN EMR data will provide, for all eligible children, individual categorical and continuous patient-level data such as patient demographics, ICD9 codes, and medication prescriptions. For children evaluated in practices randomized to the pathway group, data will also include asthma phenotype and provision of asthma action plans.
The management of pediatric asthma in Alberta is variable in quality with only half of the affected children having control of their asthma. This has adverse effects on morbidity and costs of health care. We aim to improve the quality of care in primary care by a two-pronged approach: the use of a management pathway in the practitioner’s EMR and the education of parents in the importance of preventive therapies.
At the end of the 3-year project, the rigorous pragmatic cluster-controlled design will provide a thorough and comprehensive understanding of whether this project improves patient care, how effective the interventions are, and whether the interventions add value or are cost saving. If the results are positive, we will collaborate with the AHS RHSCN, the Provincial Primary and Community Care portfolios, and the Provincial Primary Care Network to deliver this pathway and educational initiative to all Alberta primary care practices and their patients.
We wish to thank our collaborators AHS (RHSCN), HQCA, SAPCReN, and NAPCReN as well as the University of Alberta, University of Calgary, and Ottawa Hospital Research Institute for their support. We also thank Alberta Innovates Health Solutions (AIHS), AHS (RHSCN), and HQCA for funding this study. Seefor proof of peer-review from AIHS.
SS acknowledges her research personnel funding from Alberta Innovates Health Solutions and a Tier 2 Canada Research Chair. BR’s research is supported by the Canadian Institutes of Health Research (CIHR) through a Tier I Canada Research Chair in Evidence-Based Emergency Medicine (Ottawa, Ontario) and he represents the Emergency Strategic Clinical Network (ESCN) within AHS as the Scientific Director. JG holds a Canada Research Chair in Health Knowledge Transfer and Uptake and a CIHR Foundation grant. We also thank Eileen Young, Peter Blondeel, and Mirella Chiodo for their involvement.
Conflicts of Interest
Multimedia Appendix 1
Sample size sensitivity analysis.PDF File (Adobe PDF File), 38KB
Multimedia Appendix 2
Logic model for determining â€˜overall successâ€™ (appropriate treatment of symptomatic asthmatic child with preventer medication) for primary outcome.PDF File (Adobe PDF File), 27KB
Multimedia Appendix 3
Timeline of major objectives and associated milestones.PDF File (Adobe PDF File), 148KB
Multimedia Appendix 4
Peer-review from funding agency.PDF File (Adobe PDF File), 15KB
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|AHS: Alberta Health Services|
|CDM: chronic disease management|
|CPCSSN: Canadian Primary Care Sentinel Surveillance Network|
|EMR: electronic medical record|
|HQCA: Health Quality Council of Alberta|
|IHE: Institute of Health Economics|
|NAPCReN: Northern Alberta Primary Care Research Networks|
|PACQLQ: Paediatric Asthma Caregiver’s Quality of Life Questionnaire|
|RHSCN: Respiratory Health Strategic Clinical Network|
|SAPCReN: Southern Alberta Primary Care Research Networks|
|TDF: Theoretical Domains Framework|
Edited by G Eysenbach; submitted 27.10.15; peer-reviewed by T Rotter, A Plaisance; comments to author 20.12.15; accepted 07.01.16; published 08.03.16Copyright
©Andrew J Cave, Heather Sharpe, Mark Anselmo, A Dean Befus, Gillian Currie, Christina Davey, Neil Drummond, Jim Graham, Lee A Green, Jeremy Grimshaw, Karen Kam, Donna P Manca, Alberto Nettel-Aguirre, Melissa L Potestio, Brian H Rowe, Shannon D Scott, Tyler Williamson, David W Johnson. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 08.03.2016.
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