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Adjuvant Alpha-Fetoprotein-Derived Peptide After Transarterial Chemoembolization in Patients With Hepatocellular Carcinoma: Protocol for a Safety Study

Adjuvant Alpha-Fetoprotein-Derived Peptide After Transarterial Chemoembolization in Patients With Hepatocellular Carcinoma: Protocol for a Safety Study

Some immunotherapy approaches have been able to induce T cells to attack tumor cells in humans, demonstrating antitumor effects.We have screened and compared many candidates as targets for immunotherapy strategies in HCC [11-13].

Akihiro Nomura, Takeshi Terashima, Eishiro Mizukoshi, Masaaki Kitahara, Toshinori Murayama, Shuichi Kaneko

JMIR Res Protoc 2020;9(2):e17082


The Effectiveness of Artificial Intelligence Conversational Agents in Health Care: Systematic Review

The Effectiveness of Artificial Intelligence Conversational Agents in Health Care: Systematic Review

The types of input that conversational agents can receive and interpret have also expanded, with some conversational agents capable of analyzing movements, such as gestures, facial expressions, and eye movements [11,12].Conversational agents have been developed

Madison Milne-Ives, Caroline de Cock, Ernest Lim, Melissa Harper Shehadeh, Nick de Pennington, Guy Mole, Eduardo Normando, Edward Meinert

J Med Internet Res 2020;22(10):e20346


Monitoring of Vedolizumab Infusion Therapy (MOVE-IT) Response With Fecal Inflammation Markers, Ultrasound, and Trough Serum Level in Patients With Ulcerative Colitis: Protocol for a Multicentric, Prospective, Noninterventional Study

Monitoring of Vedolizumab Infusion Therapy (MOVE-IT) Response With Fecal Inflammation Markers, Ultrasound, and Trough Serum Level in Patients With Ulcerative Colitis: Protocol for a Multicentric, Prospective, Noninterventional Study

In addition, studies on antitumor necrosis factor (TNF) agents have shown that the early drug level is important to predict response to therapy [1,4].SecondaryTo predict the probability of a clinical response to a therapy with the integrin antibody vedolizumab

Jimmi Cording, Margit Blömacher, Berit Inga Wiebe, Jost Langhorst, Torsten Kucharzik, Andreas Sturm, Stefan Schreiber, Ulf Helwig

JMIR Res Protoc 2019;8(11):e14335


Building a Pharmacogenomics Knowledge Model Toward Precision Medicine: Case Study in Melanoma

Building a Pharmacogenomics Knowledge Model Toward Precision Medicine: Case Study in Melanoma

IntroductionPharmacogenomicsThe field of pharmacogenomics (PGx) has developed rapidly since the initial scientific discoveries of genetic characteristics affecting individual response to drugs or other agents [1].

Hongyu Kang, Jiao Li, Meng Wu, Liu Shen, Li Hou

JMIR Med Inform 2020;8(10):e20291


Technological Innovations in Disease Management: Text Mining US Patent Data From 1995 to 2017

Technological Innovations in Disease Management: Text Mining US Patent Data From 1995 to 2017

Chemical agents or functional groups such as “phenyl” (1995-2017) [54], “pyrazolo” (1995-2003) [55], “thieno” (2008-2013) [56], and “tetrahydroisoquinolines” (2017) [57] were most mentioned in the top 10 topic words and were reported to have antitumor effects

Ming Huang, Maryam Zolnoori, Joyce E Balls-Berry, Tabetha A Brockman, Christi A Patten, Lixia Yao

J Med Internet Res 2019;21(4):e13316