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Adjuvant Alpha-Fetoprotein-Derived Peptide After Transarterial Chemoembolization in Patients With Hepatocellular Carcinoma: Protocol for a Safety Study

Some immunotherapy approaches have been able to induce T cells to attack tumor cells in humans, demonstrating antitumor effects.We have screened and compared many candidates as targets for immunotherapy strategies in HCC [11-13].

Akihiro Nomura, Takeshi Terashima, Eishiro Mizukoshi, Masaaki Kitahara, Toshinori Murayama, Shuichi Kaneko

JMIR Res Protoc 2020;9(2):e17082

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Enzalutamide Versus Abiraterone as a First-Line Endocrine Therapy for Castration-Resistant Prostate Cancer: Protocol for a Multicenter Randomized Phase 3 Trial

In fact, hormone therapies are known to be safe and highly effective, but the biggest drawback is the lack of sustained antitumor effects [1].

Isao Hara, Shimpei Yamashita, Satoshi Nishizawa, Kazuro Kikkawa, Toshio Shimokawa, Yasuo Kohjimoto

JMIR Res Protoc 2018;7(7):e11191

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Use of the Total Cancer Care System to Enrich Screening for CD30-Positive Solid Tumors for Patient Enrollment Into a Brentuximab Vedotin Clinical Trial: A Pilot Study to Evaluate Feasibility

Bin Li, Steven A Eschrich, Anders Berglund, Melissa Mitchell, David Fenstermacher, Hadi Danaee, Hongyue Dai, Daniel Sullivan, William L Trepicchio, William S Dalton

JMIR Res Protoc 2017;6(3):e45

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The Paget Trial: A Multicenter, Observational Cohort Intervention Study for the Clinical Efficacy, Safety, and Immunological Response of Topical 5% Imiquimod Cream for Vulvar Paget Disease

It has antiviral and antitumor properties and is registered for the treatment of condylomata acuminata, actinic keratosis, and superficial basal cell carcinomas.

Michelle van der Linden, Kim Meeuwis, Colette van Hees, Eleonora van Dorst, Johan Bulten, Tjalling Bosse, Joanna IntHout, Dorry Boll, Brigitte Slangen, Manon van Seters, Marc van Beurden, Mariëtte van Poelgeest, Joanne de Hullu

JMIR Res Protoc 2017;6(9):e178

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Using Artificial Intelligence (Watson for Oncology) for Treatment Recommendations Amongst Chinese Patients with Lung Cancer: Feasibility Study

Data were collected on patients who received antitumor treatment at our center.

Chaoyuan Liu, Xianling Liu, Fang Wu, Mingxuan Xie, Yeqian Feng, Chunhong Hu

J Med Internet Res 2018;20(9):e11087

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Nonsurgical Strategies in Patients With NET Liver Metastases: A Protocol of Four Systematic Reviews

Studies combining streptozotocin with other agents have been conducted with the aim to decrease the dosage of streptozotocin, and thus reduce its toxicity [23].

Perparim Limani, Christoph Tschuor, Laura Gort, Bettina Balmer, Alexander Gu, Christos Ceresa, Dimitri Aristotle Raptis, Mickael Lesurtel, Milo Puhan, Stefan Breitenstein

JMIR Res Protoc 2014;3(1):e9

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The Effectiveness of Artificial Intelligence Conversational Agents in Health Care: Systematic Review

The types of input that conversational agents can receive and interpret have also expanded, with some conversational agents capable of analyzing movements, such as gestures, facial expressions, and eye movements [11,12].Conversational agents have been developed

Madison Milne-Ives, Caroline de Cock, Ernest Lim, Melissa Harper Shehadeh, Nick de Pennington, Guy Mole, Eduardo Normando, Edward Meinert

J Med Internet Res 2020;22(10):e20346

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Monitoring of Vedolizumab Infusion Therapy (MOVE-IT) Response With Fecal Inflammation Markers, Ultrasound, and Trough Serum Level in Patients With Ulcerative Colitis: Protocol for a Multicentric, Prospective, Noninterventional Study

In addition, studies on antitumor necrosis factor (TNF) agents have shown that the early drug level is important to predict response to therapy [1,4].SecondaryTo predict the probability of a clinical response to a therapy with the integrin antibody vedolizumab

Jimmi Cording, Margit Blömacher, Berit Inga Wiebe, Jost Langhorst, Torsten Kucharzik, Andreas Sturm, Stefan Schreiber, Ulf Helwig

JMIR Res Protoc 2019;8(11):e14335

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Building a Pharmacogenomics Knowledge Model Toward Precision Medicine: Case Study in Melanoma

IntroductionPharmacogenomicsThe field of pharmacogenomics (PGx) has developed rapidly since the initial scientific discoveries of genetic characteristics affecting individual response to drugs or other agents [1].

Hongyu Kang, Jiao Li, Meng Wu, Liu Shen, Li Hou

JMIR Med Inform 2020;8(10):e20291

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Technological Innovations in Disease Management: Text Mining US Patent Data From 1995 to 2017

Chemical agents or functional groups such as “phenyl” (1995-2017) [54], “pyrazolo” (1995-2003) [55], “thieno” (2008-2013) [56], and “tetrahydroisoquinolines” (2017) [57] were most mentioned in the top 10 topic words and were reported to have antitumor effects

Ming Huang, Maryam Zolnoori, Joyce E Balls-Berry, Tabetha A Brockman, Christi A Patten, Lixia Yao

J Med Internet Res 2019;21(4):e13316

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