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Currently submitted to: JMIR Research Protocols

Date Submitted: May 24, 2020
Open Peer Review Period: May 24, 2020 - Jul 7, 2020
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Tuina for Chronic Non-specific Low Back Pain: a systematic review and meta-analysis

  • Juan Yang; 
  • Jeffrey S. Brault; 
  • Mark A. Jensen; 
  • Alexander Do; 
  • Qingyu Ma; 
  • Longbin Shen; 
  • Canghuan Zhao; 
  • Kwok Chee Philip Cheong; 
  • Kejie He; 
  • Yu Guo; 
  • Zhuoming Chen; 
  • Shujie Tang; 
  • Yong Tang; 
  • Celia Tan Ia Choo; 
  • Jiaxu Chen; 
  • Brent A. Bauer; 



Chronic non-specific low back pain (CNLBP) is one of the most common complex conditions strongly associated with high rates of disability. Even though many studies on Tuina for CNLBP patients reported, until now, there is no study synthesize the currently available publications.


This protocol aims to provide authors the guideline used to systematically review the effect and safety of Tuina therapy for treating patients with CNLBP.


An electronic literature search will be conducted in the following databases: MEDLINE, Embase, Cochrane Library, Springer, Web of Science, Scopus, World Health Organization International Clinical Trials Registry Platform (ICTRP), the Chinese Biomedical Literature Database (CBM), the China National Knowledge Infrastructure (CNKI), Wan-fang database (WAN FANG), Chinese Biomedical Literature Databases (CBM), and Chinese Scientific Journal Database VIP Information (VIP). From database inception to Dec 30, 2019, English, and Chinese language only. Randomized controlled trials (RCTs) involving Tuina for patients with CNLBP will be reviewed. The primary outcomes of the study are an improvement of pain, analgesic medication reduction, improvement of functional disability, and degree of satisfaction with the intervention. A secondary outcome is any adverse event (AE) of Tuina intervention. If samples are enough, a meta-analysis with the software RevMan5.3.5 will be performed. If data permit, a subgroup analysis will be conducted to explain the study findings.


The study was started on April 30th, 2020. Study results will be submitted for publication in July 2020.


This protocol will establish a framework of a high-quality literature synthesis on the impact of Tuina treatment in patients with CNLBP. The proposed review will determine whether Tuina is effective and safe for CNLBP patients. Clinical Trial: PROSPERO CRD42020166731


Please cite as:

Yang J, Brault JS, Jensen MA, Do A, Ma Q, Shen L, Zhao C, Cheong KCP, He K, Guo Y, Chen Z, Tang S, Tang Y, Choo CTI, Chen J, Bauer BA

Tuina for Chronic Non-specific Low Back Pain: a systematic review and meta-analysis

JMIR Preprints. 24/05/2020:20615

DOI: 10.2196/preprints.20615


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