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Currently accepted at: JMIR Research Protocols

Date Submitted: Nov 6, 2019
Date Accepted: Dec 16, 2019
(closed for review but you can still tweet)

This paper has been accepted and is currently in production.

It will appear shortly on 10.2196/16935

The final accepted version (not copyedited yet) is in this tab.

Application of “Internet of Things” in Cell-Based Therapy Delivery: A Systematic Review Protocol

  • Ching Lam; 
  • Michelle Helena van Velthoven; 
  • Edward Meinert; 



Internet of Things (IoT) or Industry 4.0, represents a ‘smart’ shift to more interconnected manufacturing processes where individual entities within the supply chain communicate with each other in order to achieve greater flexibility and responsiveness in manufacturing and leaner manufacturing to reduce cost of production. IoT has proven itself instrumental in driving leaner manufacturing and more efficient systems in other industries such as transportation and logistics. While cell-based therapeutic products hold the promise of transforming various diseases, the delivery of these products is complex and challenging.


This review aims to understand the applicability of IoT in cell-based product supply chain and delivery.


We will search Medline, EMBASE (OvidSP), Web of Science, Cochrane Library & HEED, Scopus, ACM digital library, INSPEC, ScienceDirect and the IEEE Xplore Digital Library for studies published after 2008 using a combination of keywords and subject headings related to IoT used in cell therapies. In addition, a Google search to identify grey literature will be conducted. Two authors will independently screen the titles and abstracts identified from the search and accept or reject the studies according to the study inclusion criteria, and any discrepancies will then be discussed and resolved. The quality of the selected literature will be assessed using the CASP Systematic Review checklist.


Data from eligible publications will be abstracted into a predesigned form in order to map the current and future directions of the technologies, application and challenges in the implementation of IoT in regenerative medicine.


This study is an analysis of publicly available primary and secondary literature and therefore does not require ethical review. The executed study conducted later will be published in a peer-reviewed journal in accordance with PRISMA guidelines.


Please cite as:

Lam C, van Velthoven MH, Meinert E

Application of “Internet of Things” in Cell-Based Therapy Delivery: A Systematic Review Protocol

DOI: 10.2196/16935


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