Maintenance Notice

Due to necessary scheduled maintenance, the JMIR Publications website will be unavailable from Monday, March 11, 2019 at 4:00 PM to 4:30 PM EST. We apologize in advance for any inconvenience this may cause you.

Who will be affected?

Advertisement

Currently accepted at: JMIR Research Protocols

Date Submitted: May 14, 2019
Open Peer Review Period: May 17, 2019 - May 31, 2019
Date Accepted: Aug 7, 2019
(closed for review but you can still tweet)

This paper has been accepted and is currently in production.

It will appear shortly on 10.2196/14704

The final accepted version (not copyedited yet) is in this tab.

American Cohort to Study HIV Acquisition Among Transgender Women in High-Risk Areas (the LITE study): Protocol for a Multisite Prospective Cohort Study in the Eastern and Southern United States

  • Andrea L Wirtz; 
  • Tonia Poteat; 
  • Asa Radix; 
  • Keri N Althoff; 
  • Christopher M Cannon; 
  • Andrew J Wawrzyniak; 
  • Erin Cooney; 
  • Kenneth H Mayer; 
  • Chris Beyrer; 
  • Allan E Rodriguez; 
  • Sari L Reisner; 
  • American Cohort To Study HIV Acquisition Among Transgender Women (LITE)

Background:

In the United States, transgender women (TW) are disproportionately burdened by HIV infection. Cohort studies are needed to evaluate factors driving HIV acquisition among TW over time. These will require implementation strategies that are acceptable to the TW community and feasible to implement.

Objective:

This study aims to investigate the rate and correlates of HIV acquisition and other health outcomes among TW in eastern and southern United States.

Methods:

LITE is a multisite prospective cohort in 6 eastern and southern US cities, which will be followed across 24 months of technology-enhanced biobehavioral follow-up. Adult TW, regardless of HIV status, are recruited via convenience sampling (eg, peer referrals, social media, and dating apps). Participants are enrolled in a baseline study visit, complete a sociobehavioral survey, and test for HIV and sexually transmitted infections. Participants who are not living with HIV at baseline are offered enrollment into the cohort (N=1100); follow-up assessments occur quarterly.

Results:

Cohort assembly was informed by synchronous Web-based focus group discussions with TW (n=41) and by continuing engagement with community advisory board members from each site. Enrollment launched in March 2018. The study is underway in the Atlanta; Baltimore; Boston; Miami; New York City; and Washington, DC, metro areas. As of March 2019, 795 TW completed a baseline visit (mean age 35 years). The majority of the participants are racial/ethnic minorities, with 45% of the TW identifying as black and 28% of the TW identifying as Hispanic/Latinx. More than one-quarter (28%) of the TW are living with HIV infection (laboratory-confirmed). Online recruitment methods support engagement with TW, although peer referral and referral through trusted health facilities and organizations remain most effective.

Conclusions:

This study is responsive to increasing research interest in technology-enhanced methods for cohort research, particularly for hard-to-reach populations. Importantly, the diversity of literacy, technology use, and overall socioeconomic situations in this sample of TW highlights the need to leverage technology to permit a flexible, adaptive methodology that enhances engagement of potential participants living in marginalized contexts while still ensuring rigorous and sound study design.


 Citation

Please cite as:

Wirtz AL, Poteat T, Radix A, Althoff KN, Cannon CM, Wawrzyniak AJ, Cooney E, Mayer KH, Beyrer C, Rodriguez AE, Reisner SL, American Cohort To Study HIV Acquisition Among Transgender Women (LITE)

American Cohort to Study HIV Acquisition Among Transgender Women in High-Risk Areas (the LITE study): Protocol for a Multisite Prospective Cohort Study in the Eastern and Southern United States

JMIR Research Protocols. (forthcoming/in press)

DOI: 10.2196/preprints.14704

URL: https://preprints.jmir.org/preprint/14704


Request queued. Please wait while the file is being generated. It may take some time.

© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.