TY  - JOUR
AU  - El-Koubani, Osman
AU  - McCann, Mark
AU  - Christmas, Daniel
AU  - Khanna, Aakash
AU  - von Maydell, Alexander
PY  - 2019
DA  - 2019/08/20
TI  - Radiofrequency-Assisted Liver Resection Versus Clamp-Crush Liver Resection: Protocol for an Updated Meta-Analysis and Systematic Review
JO  - JMIR Res Protoc
SP  - e13437
VL  - 8
IS  - 8
KW  - radiofrequency
KW  - hepatectomy
KW  - systematic review
KW  - meta-analysis
AB  - Background: Malignancy of the liver has historically meant a poor prognosis and remains the second most common cause of cancer-related deaths globally. Traditionally, hepatectomy has utilized the clamp-crush technique; however, this is associated with high incidence of postoperative complications. Many novel techniques have been developed—radiofrequency ablation and transarterial chemoembolization; however, these are not applicable to numerous cases. Clamp-crush liver resection (CCLR) remains the gold standard. Radiofrequency-assisted liver resection (RFLR) is a technique that aims to reduce mortality through bloodless liver resection. A systematic review was previously performed on RFLR but the results neither recommended nor refuted the use of RFLR owing to the lack of sufficient evidence from well-designed randomized controlled trials (RCTs) at the time. Objective: The aim of the study is the meta-analysis and systematic review of recent studies comparing RFLR against CCLR. Methods: Articles comparing RFLR and CCLR that were published from 2014 until 2019 will be reviewed and relevant data will be extracted and statistically analyzed through Review Manager 5 (by the Cochrane Collaboration) together with the results of the previous meta-analysis. Results: Data collection is currently underway, with papers being screened. We hope to publish the results by the end of 2019. Conclusions: Given the high mortality rates currently associated with liver resection, it is imperative that novel surgical techniques are undertaken and investigated so we can improve best practice guidance and outcomes. International Registered Report Identifier (IRRID): DERR1-10.2196/13437 
SN  - 1929-0748
UR  - https://www.researchprotocols.org/2019/8/e13437/
UR  - https://doi.org/10.2196/13437
UR  - http://www.ncbi.nlm.nih.gov/pubmed/31432783
DO  - 10.2196/13437
ID  - info:doi/10.2196/13437
ER  -