<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="research-article"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Res Protoc</journal-id><journal-id journal-id-type="publisher-id">ResProt</journal-id><journal-id journal-id-type="index">5</journal-id><journal-title>JMIR Research Protocols</journal-title><abbrev-journal-title>JMIR Res Protoc</abbrev-journal-title><issn pub-type="epub">1929-0748</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v14i1e74298</article-id><article-id pub-id-type="doi">10.2196/74298</article-id><article-categories><subj-group subj-group-type="heading"><subject>Protocol</subject></subj-group></article-categories><title-group><article-title>The Influence of Virtual Reality Glasses Use on the Quality of Life of Older Adults: Protocol for a Prospective, Longitudinal Quasi-Experimental Study</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Borda Fortuny</surname><given-names>D&#x00E8;lia</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Rivas L&#x00F3;pez</surname><given-names>Sandra</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Mart&#x00ED;nez-Torres</surname><given-names>Sara</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Rey-Re&#x00F1;ones</surname><given-names>Cristina</given-names></name><degrees>NR, PhD</degrees><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Mart&#x00ED;n-Luj&#x00E1;n</surname><given-names>Francisco M</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff5">5</xref></contrib></contrib-group><aff id="aff1"><institution>Institut Catala de Salut, Primary Healthcare Centre</institution><addr-line>Valls</addr-line><country>Spain</country></aff><aff id="aff2"><institution>ISAC Study Group, Primary Healthcare Research Support Unit Camp de Tarragona, Institut Universitari d'Investigaci&#x00F3; en Atenci&#x00F3; Prim&#x00E0;ria Jordi Gol</institution><addr-line>c/Riudoms 53-55</addr-line><addr-line>Reus, Catalunya</addr-line><country>Spain</country></aff><aff id="aff3"><institution>Department of Basic Medical Sciences and Department of Medicine and Surgery, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili</institution><addr-line>Reus, Catalunya</addr-line><country>Spain</country></aff><aff id="aff4"><institution>TIC-AP Study Group, Primary Healthcare Research Support Unit Camp de Tarragona, Institut Universitari d'Investigaci&#x00F3; en Atenci&#x00F3; Prim&#x00E0;ria Jordi Gol</institution><addr-line>Reus, Catalunya</addr-line><country>Spain</country></aff><aff id="aff5"><institution>Primary Healthcare Study Group, Institut d'Investigaci&#x00F3; Sanit&#x00E0;ria Pere Virgili</institution><addr-line>Tarragona</addr-line><country>Spain</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Sarvestan</surname><given-names>Javad</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Costa</surname><given-names>Jose Ferrer</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Lemonde</surname><given-names>Manon</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Cristina Rey-Re&#x00F1;ones, NR, PhD, ISAC Study Group, Primary Healthcare Research Support Unit Camp de Tarragona, Institut Universitari d'Investigaci&#x00F3; en Atenci&#x00F3; Prim&#x00E0;ria Jordi Gol, c/Riudoms 53-55, Reus, Catalunya, 43302, Spain, +34 977778515; <email>cristina.rey@urv.cat</email></corresp><fn fn-type="equal" id="equal-contrib1"><label>*</label><p>these authors contributed equally</p></fn></author-notes><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2025</year></pub-date><volume>14</volume><elocation-id>e74298</elocation-id><history><date date-type="received"><day>21</day><month>03</month><year>2025</year></date><date date-type="rev-recd"><day>30</day><month>10</month><year>2025</year></date><date date-type="accepted"><day>31</day><month>10</month><year>2025</year></date></history><copyright-statement>&#x00A9; D&#x00E8;lia Borda Fortuny, Sandra Rivas L&#x00F3;pez, Sara Mart&#x00ED;nez-Torres, Cristina Rey-Re&#x00F1;ones, Francisco M Mart&#x00ED;n-Luj&#x00E1;n. Originally published in JMIR Research Protocols (<ext-link ext-link-type="uri" xlink:href="https://www.researchprotocols.org">https://www.researchprotocols.org</ext-link>), 23.12.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://www.researchprotocols.org">https://www.researchprotocols.org</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://www.researchprotocols.org/2025/1/e74298"/><abstract><sec><title>Background</title><p>Older adults are a rapidly growing demographic and often face social isolation and limited access to outdoor activities due to mobility issues, health conditions, and environmental barriers. These limitations can negatively impact their well-being, leading to reduced physical activity, cognitive decline, and emotional distress. Virtual reality (VR) technology offers a promising solution to bridge this gap by enabling access to immersive virtual environments, which may enhance the quality of life for residents in nursing homes.</p></sec><sec><title>Objective</title><p>The aim of this study is to assess whether the use of VR glasses in nursing homes improves the quality of life of older adults by reducing the challenges they face in participating in recreational activities outside their care facilities.</p></sec><sec sec-type="methods"><title>Methods</title><p>This study will adopt a prospective, longitudinal quasi-experimental design conducted in nursing homes within a basic health area of Catalonia, Spain. The intervention period will span 1 year. Participants will use VR glasses to interact with virtual environments, and their quality of life will be measured using the Rivas-Borda Quality of Life Scale, based on other validated scales.</p></sec><sec sec-type="results"><title>Results</title><p>Outcomes will focus on variations in quality-of-life scores before and after the intervention, as determined by the Rivas-Borda Scale. Statistical analysis will include detailed metrics such as sample size, confidence intervals, and <italic>P</italic> values to evaluate the intervention&#x2019;s effectiveness.</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>This research seeks to confirm that VR technology can be a valuable tool for enhancing the quality of life in older adults residing in nursing homes, addressing issues like social isolation and limited access to outdoor activities in an innovative and engaging way.</p></sec><sec><title>Trial Registration</title><p>ClinicalTrials.gov NCT06668740; <ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/study/NCT06668740">https://clinicaltrials.gov/study/NCT06668740</ext-link></p></sec><sec sec-type="registered-report"><title>International Registered Report Identifier (IRRID)</title><p>PRR1-10.2196/74298</p></sec></abstract><kwd-group><kwd>virtual reality</kwd><kwd>quality of life</kwd><kwd>aged</kwd><kwd>primary health care</kwd><kwd>public health</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><sec id="s1-1"><title>Background</title><p>Quality of life (QoL) in older adults is a multidimensional concept that encompasses various crucial aspects of well-being and fulfillment as individuals age [<xref ref-type="bibr" rid="ref1">1</xref>]. The global increase in the older adult population, projected to nearly double from 12% in 2015 to 22% in 2050, presents significant challenges for societies worldwide [<xref ref-type="bibr" rid="ref2">2</xref>]. This demographic shift requires innovative approaches to maintain and enhance the QoL for older adults, particularly as they face unique physical, cognitive, and social challenges associated with aging.</p><p>Active aging has emerged as a holistic framework aimed at enhancing physical, cognitive, and emotional health, thereby improving the QoL for older adults. By promoting physical activity, social engagement, and healthy lifestyle choices, active aging effectively addresses the challenges associated with aging [<xref ref-type="bibr" rid="ref3">3</xref>-<xref ref-type="bibr" rid="ref6">6</xref>]. Recent research has highlighted the importance of multifaceted interventions that target various domains of well-being, including physical health, cognitive function, and social connectivity [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref8">8</xref>].</p><p>In recent years, emerging technologies&#x2014;including robotics, virtual reality (VR), and smart textiles&#x2014;have gained prominence for fostering healthy lifestyles among middle-aged and older adult populations. These innovative technologies play a crucial role in addressing issues such as social isolation and supporting active aging [<xref ref-type="bibr" rid="ref9">9</xref>]. VR, in particular, has demonstrated considerable versatility and moderate cost, with applications spanning health domains including pain management, cognitive health, physical rehabilitation, and social well-being [<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref15">15</xref>].</p><p>The potential of VR in health care for older adults has been extensively explored in recent literature. Studies have shown promising results in areas such as fall prevention, cognitive stimulation, and physical therapy [<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref17">17</xref>]. Moreover, VR interventions have been found to improve mood and reduce anxiety in older adults, contributing to overall psychological well-being [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>].</p><p>Despite these advancements, some studies have primarily focused on enhancing physical and cognitive functional capacities of individuals affected by specific diseases; a holistic perspective on QoL improvement remains underexplored. Current studies predominantly focus on neurodegenerative diseases and fall prevention in neurological patients, often overlooking broader determinants of QoL and their integration into aging interventions [<xref ref-type="bibr" rid="ref20">20</xref>-<xref ref-type="bibr" rid="ref22">22</xref>].</p><p>This study aims to assess whether 4 practical sessions, conducted using VR glasses, can improve QoL in older adults residing in geriatric facilities&#x2014;a population frequently experiencing diminished well-being. Furthermore, this research emphasizes the importance of collaboration across various societal domains to address the multifaceted challenges of aging. Specifically, it integrates the social dimension, leveraging the support of the local municipal organization VallsGenera; the educational dimension, through partnerships with local schools; the technological dimension, using VR technology; and the health care dimension, by addressing the well-being and mental health of older adults in geriatric facilities. By fostering these interdisciplinary collaborations, this innovative approach aspires to bridge the digital divide faced by older adults and comprehensively enhance their QoL.</p><p>The integration of VR technology in geriatric care represents a promising avenue for enhancing the quality of life of older adults. By providing immersive experiences that stimulate cognitive function, promote physical activity, and facilitate social interaction, VR interventions have the potential to significantly impact various dimensions of well-being [<xref ref-type="bibr" rid="ref8">8</xref>,<xref ref-type="bibr" rid="ref19">19</xref>]. This study contributes to the growing body of research on technology-assisted interventions for older adults and aims to provide valuable insights into the efficacy of VR in improving overall quality of life in geriatric populations.</p></sec><sec id="s1-2"><title>Hypothesis</title><p>Participants who engage in the VR experience will report a significant improvement in perceived psychosocial well-being, as measured by the study-specific questionnaire.</p></sec></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Study Objectives</title><p>The general objective of this study is to evaluate whether conducting 4 practical VR sessions using VR glasses improves the quality of life of older adults.</p><p>The specific objectives are as follows:</p><list list-type="bullet"><list-item><p>To analyze whether the emotional and cognitive well-being of participants improves according to the questionnaire created for this study.</p></list-item><list-item><p>To identify whether there is an improvement in the sociofamiliar and physical dimension areas of the participants according to the questionnaire created for this study.</p></list-item><list-item><p>To assess user satisfaction with practical VR sessions using VR glasses for older adults.</p></list-item></list></sec><sec id="s2-2"><title>Study Design, Setting, and Period</title><p>This is a prospective longitudinal quasi-experimental study designed to assess the impact of VR sessions on the QoL of older adults. The study will be conducted in all nursing homes within the basic health area of Valls (Catalonia, Spain). Valls is an inland city in the southern part of Catalonia and has a population of 25,047 [<xref ref-type="bibr" rid="ref23">23</xref>].</p><p>The intervention period will span 1 year. The general framework and participant timeline of this study are shown in <xref ref-type="fig" rid="figure1">Figure 1</xref>.</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>Flowchart of the VRLife study, showing the process of the screening, preintervention, intervention, and postintervention phases. QoL: quality of life.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="resprot_v14i1e74298_fig01.png"/></fig></sec><sec id="s2-3"><title>Institutional Involvement</title><p>The study involves collaboration with multiple entities: the Narc&#x00ED;s Oller Institute, where students volunteered to assist with the intervention; VallsGenera, which will provide the necessary resources for the study; and all geriatric residences of Valls, named Alt Camp, Montserrat Cuadrada, and l&#x2019;Alba, which will actively participate in the project.</p><p>Secondary school students from the Narc&#x00ED;s Oller Institute, who were previously invited to participate, will visit the residential facilities to support the VR intervention. Their role has been clearly defined to focus primarily on technical assistance, with limited and standardized social interaction. Students will receive structured training from the nurses leading the study, which specifies the aspects of the intervention they may guide or assist with, ensuring consistency across sessions and minimizing variability in interpersonal interactions. The nurses will oversee all intervention procedures, provide supervision, and coordinate scheduling with both the educational institution and residential centers to arrange the sessions.</p></sec><sec id="s2-4"><title>Participant Selection</title><p>Eligible participants will include older adults residing in nursing homes in Valls who experience limitations in participating in recreational activities outside their care facilities. All residents who meet the criteria will be considered as potential participants. Invitations to participate will be extended in accordance with the predefined inclusion and exclusion criteria.</p><p>Inclusion criteria are as follows:</p><list list-type="bullet"><list-item><p>Aged 65 years or older</p></list-item><list-item><p>Individuals presenting with slight, moderate, significant, or complete impairment in social resources, as assessed by the Older Americans Resources and Services (OARS) methodology developed by Duke University (1978), which was adapted into a Spanish version [<xref ref-type="bibr" rid="ref24">24</xref>].</p></list-item></list><p>Exclusion criteria are as follows:</p><list list-type="bullet"><list-item><p>History of frequent migraines or motion sickness</p></list-item><list-item><p>Moderate to severe cognitive impairment (&#x2265;5 errors on the Abbreviated Pfeiffer Test) [<xref ref-type="bibr" rid="ref25">25</xref>]</p></list-item><list-item><p>Advanced visual and/or hearing impairment</p></list-item><list-item><p>Inability to communicate in either Spanish or Catalan</p></list-item></list></sec><sec id="s2-5"><title>Recruitment and Data Collection</title><p>The study will be presented to the management teams of the participating nursing homes. Upon approval, all residents will be informed about the study and invited to participate. Eligible individuals will be identified by the research team based on their residence in the basic health area of Valls and their compliance with inclusion and exclusion criteria. Those meeting the inclusion criteria and none of the exclusion criteria will be formally invited to participate.</p><p>Interested participants will receive detailed information about the study and will be asked to provide written informed consent prior to enrollment. As part of the screening process, participants will complete both the Abbreviated Pfeiffer Test and the OARS questionnaire, which will be used to assess cognitive status and social resources, respectively, in relation to the eligibility criteria.</p></sec><sec id="s2-6"><title>Sample Size</title><p>The effect size of VR on QoL has been established at 20 points [<xref ref-type="bibr" rid="ref26">26</xref>]. Accepting an &#x03B1; risk of 0.05 and a power of 0.9 in a 2-tailed test, 59 subjects are needed in the observed group to recognize a difference as statistically significant. A dropout rate of 15% has been anticipated. The sample size was calculated using GRANMO (version 8) [<xref ref-type="bibr" rid="ref27">27</xref>], a general, independent power analysis program for commonly used statistical tests in research.</p></sec><sec id="s2-7"><title>Description of the Intervention</title><p>Following the screening process, all eligible participants will undergo the intervention (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>). The program consists of 4 VR sessions, each lasting 10 minutes, delivered once per week over a 1-month period. Sessions will take place in a safe, open space that allows for comfortable movement, with participants seated and supervised by trained nursing staff. Participants will use Conformit&#x00E9; Europ&#x00E9;enne&#x2013;marked NK VR headsets to access immersive 360&#x00B0; videos featuring passive, recreational content. These videos depict outdoor landscapes such as forests, beaches, mountains, and parks. A total of 10 distinct videos are available, and participants may choose freely among them and repeat any session if desired. The VR experience includes both visual and auditory elements to enhance the sense of presence and engagement. The intervention is standardized across all sessions and participants, ensuring consistency in delivery while allowing for individual preferences in video selection.</p><p>VR headsets will be disinfected between each use in accordance with institutional hygiene protocols to ensure participant safety and minimize the risk of cross-contamination.</p><p>To assess outcomes, participants will complete the World Health Organization Quality of Life of older adults (WHOQOL-OLD) questionnaire at 3 time points: baseline (preintervention), immediately postintervention, and at follow-up (3&#x2010;5 mo after the intervention). This validated instrument serves as the primary measure of QoL in this study.</p><p>In addition, participants will complete the Rivas-Borda QoL Scale, an exploratory tool developed ad hoc for this project. This scale assesses 4 dimensions of quality of life&#x2014;sociofamilial, physical, emotional, and cognitive&#x2014;using a 4-level frequency rating (never/almost never, sometimes, frequently, always/almost always). Although not yet formally validated, the scale is theoretically grounded in established instruments such as WHOQOL-OLD [<xref ref-type="bibr" rid="ref28">28</xref>], EQ-5D [<xref ref-type="bibr" rid="ref29">29</xref>], and the 36-Item Short Form Health Survey [<xref ref-type="bibr" rid="ref30">30</xref>]. Detailed information about the Rivas-Borda Scale is provided in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>.</p><sec id="s2-7-1"><title>Study Variables and Data Sources</title><p>The primary outcome will be the difference in QoL scores before and after the intervention, measured using the Rivas-Borda QoL Scale.</p><p>The criteria used to establish QoL will be the following:</p><list list-type="bullet"><list-item><p>Adequate level of QoL: 81&#x2010;104 points</p></list-item><list-item><p>Risk of QoL deterioration: 54&#x2010;80 points</p></list-item><list-item><p>Impaired QoL: 23&#x2010;53 points</p></list-item></list><p>Independent variables included:</p><list list-type="bullet"><list-item><p>Sociodemographic data included in the Rivas-Borda QoL Scale: gender (woman, man, or nonbinary), age (years), and marital status (single, widowed, married or with a partner living in the nursing home, married or with a partner not living in the nursing home)</p></list-item><list-item><p>Satisfaction regarding the intervention, measured through a satisfaction questionnaire composed of a 3-question survey with 4 response options (<xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref>)</p></list-item><list-item><p>Cognitive impairment, measured with the Pfeiffer Abbreviated Test</p></list-item><list-item><p>Social resources, measured with the OARS</p></list-item></list><p>It is important to note that this information will be provided voluntarily by the older adult participants in the study and will be pseudonymized. Different variables are specifically detailed in Table S1 in <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>.</p></sec></sec><sec id="s2-8"><title>Statistical Analysis</title><p>Quantitative data following a normal distribution will be presented as means and standard deviations, while nonnormally distributed quantitative data will be expressed as medians and interquartile ranges. The normality of variables will be assessed using the Kolmogorov-Smirnov test. Categorical data will be reported as frequencies and percentages.</p><p>First, a descriptive analysis of the study population will be conducted. Then, comparisons will be made to evaluate changes in variables before and after the intervention within the same group (paired analysis). For nonnormally distributed variables or sample sizes smaller than 30, the Wilcoxon signed-rank test will be used. In contrast, the paired Student <italic>t</italic> test will be applied to variables that follow a normal (Gaussian) distribution.</p></sec><sec id="s2-9"><title>Ethical Considerations</title><p>The study will be conducted in agreement with the principles of the Declaration of Helsinki and the guidelines of Good Clinical Practice. The Clinical Research Ethics Committee of the Primary Care Research Institute Jordi Gol (IDIAP Jordi Gol) (23/155P) approved this protocol. Data confidentiality will be protected by the Spanish law governing the protection of personal data (<italic>Ley Org&#x00E1;nica de Protecci&#x00F3;n de Datos de Car&#x00E1;cter Personal y garant&#x00ED;a de los derechos digitales</italic>; 03/2018, of December 5). All participants will receive an information sheet from which they will be informed that their participation is anonymous, confidential, and voluntary and that they have the right to change their mind (not to participate) at any time up to data verification. Participants will be able to ask questions and receive clarification from the research team before deciding to participate. Verbal and written consent will be obtained from all participants to participate and be audio-recorded in the study. There will be no financial compensation for participation in the study.</p><p>All of the information from the study will be recorded consistently using a data collection questionnaire designed for this purpose. Each participant will be assigned a personal identification code upon inclusion. All information obtained will be stored using a digital application accessible only from the corporate intranet of the Catalan Health Institute in Tarragona. Access to this site is restricted and will be controlled by a personal password for each investigator, who will be responsible for data entry for all of the participants recruited. This data will not be publicly available, but the principal investigator may access it upon reasonable request and with the approval of the Research Ethics Committee for Human Subjects at IDIAP Jordi Gol. To disseminate the findings, a summary of the results will be emailed to the participants&#x2019; residential centers and presented to the research teams. The findings will also be shared with the scientific community through peer-reviewed publications and conference presentations, and dissemination in nonspecialized settings is also planned.</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><p>The study anticipates that VR interventions will significantly enhance the QoL of older adults, with expected improvements in cognitive engagement, emotional regulation, physical activity, and social participation [<xref ref-type="bibr" rid="ref27">27</xref>]. Moreover, by introducing this technology, participants may gain confidence in interacting with digital tools, contributing to reduced technological apprehension and fostering broader digital inclusion.</p><p>This research has not received any specific grant funding from public, commercial, or nonprofit funding agencies as of December 2025. The research team will apply for specific funding opportunities. As of December 2025, the research team has conducted a pilot study with 22 participants. Preliminary data analysis has been completed, and the results are expected to be published during the first half of 2026.</p></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><sec id="s4-1"><title>Rationale and Study Design</title><p>The study has been designed to address the often-overlooked aspect of QoL in older adults, emphasizing its importance across cognitive, physical, and emotional domains. By using VR technology, we seek to improve various dimensions of well-being, including cognitive, physical, and emotional domains. This approach aligns with recent research highlighting the potential benefits of VR in health care applications for older adults, such as cognitive stimulation, physical rehabilitation, and emotional well-being [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>].</p><p>Furthermore, the research seeks to bridge the digital divide experienced by older adults by introducing and familiarizing them with new technologies, aiming to reduce the gap in digital literacy and promote a sense of empowerment and inclusion.</p></sec><sec id="s4-2"><title>Strengths</title><p>One of the key strengths of this study is its focus on QoL, a critical factor that is often neglected in older adults despite its profound influence on several dimensions of well-being including cognitive, physical, and emotional. By introducing VR technology in a supportive environment, we aim to increase digital literacy and access to technological benefits among this demographic [<xref ref-type="bibr" rid="ref32">32</xref>].</p><p>The use of VR also provides a safe and controlled setting for older adults to engage in activities that might otherwise be challenging or impossible in their daily lives, such as travel or physical exercise [<xref ref-type="bibr" rid="ref33">33</xref>].</p><p>Another strength of our approach is the potential for VR to positively enhance the mental health of older adults, particularly those with cognitive impairments, by eliciting positive affective states and enhancing emotional regulation [<xref ref-type="bibr" rid="ref34">34</xref>]. This intervention could significantly improve health-related QoL in this population.</p></sec><sec id="s4-3"><title>Limitations</title><p>It is important to acknowledge the limitations of our study. First, the focus on a specific locality may limit the generalizability of our results to other geographic or cultural contexts. Additionally, there is a general lack of knowledge about the integration of VR in clinical contexts, which may pose challenges in the implementation and interpretation of results.</p><p>Previous research in this field has often been characterized by small sample sizes and controlled designs, with significant diversity in VR systems and content used across studies. This heterogeneity makes it difficult to draw direct comparisons between studies and underscores the need for more rigorous methodological approaches [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref36">36</xref>].</p><p>A significant challenge in implementing VR technology with older adults is the potential complexity of use, especially for those unfamiliar with such devices. Some participants may find it difficult to incorporate VR into their daily lives or to learn how to use it effectively [<xref ref-type="bibr" rid="ref37">37</xref>]. This difficulty can lead to feelings of frustration or inadequacy, potentially impacting the overall experience and outcomes of the intervention.</p><p>A limitation of this study is the relatively short duration and low frequency of the intervention (four 10-minute VR sessions over one month). This intervention may not be sufficient to produce measurable or sustained improvements in multidimensional outcomes such as QoL. The decision to adopt this format was based on feasibility and safety considerations in an institutionalized older adult population, where tolerance and fatigue are relevant concerns. Nevertheless, future research should evaluate more intensive interventions, including multiple sessions per week over extended periods, as well as the inclusion of follow-up assessments (eg, 3&#x2010;5 months postintervention) to better capture potential long-term effects.</p></sec><sec id="s4-4"><title>Conclusion</title><p>This study aims to fill gaps in existing research by demonstrating the potential benefits of VR technology in improving QoL for older adults. The limitations identified highlight the importance of continued exploration and iterative development of VR tools. Efforts should also be directed toward ensuring accessibility and addressing usability challenges, thereby making these technologies truly inclusive and effective for this population.</p></sec></sec></body><back><ack><p>The authors would like to thank the Primary Health Care Research Institute IDIAP Jordi Gol for providing assistance. Moreover, the implementation of the study protocol will be possible thanks to the generous collaboration of the primary care team of Valls and the three nursing homes (Alba, Montserrat Quadrada, and Alt Camp).</p></ack><notes><sec><title>Funding</title><p>The article processing charge was funded by the Departament de Recerca i Universitats de la Generalitat de Catalunya to Intervencions Sanitaries i Accions Comunit&#x00E0;ries (ISAC) Research Group (2021 SGR 00884). The virtual glasses were provided through a collaboration between VallsGenera and the i2CAT foundation. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.</p></sec><sec><title>Data Availability</title><p>The data generated and analyzed during this study will not be deposited in a public repository due to privacy and ethical considerations related to the study population. However, the datasets will be made available upon reasonable request to the corresponding author. Requests will be evaluated to ensure compliance with ethical standards and data protection regulations.</p></sec></notes><fn-group><fn fn-type="con"><p>Conceptualization: DBF, SRL</p><p>Funding acquisition: CRR, FMML</p><p>Investigation: all authors</p><p>Methodology: SMT, CRR, FMML</p><p>Project administration: DBF, SRL, CRR</p><p>Resources: DBF, SRL</p><p>Supervision: SMT, CRR</p><p>Validation: SMT, CRR</p><p>Visualization: DBF, SRL</p><p>Writing &#x2013; original draft: all authors</p><p>Writing &#x2013; review &#x0026; editing: all authors</p><p>All authors declare that generative artificial intelligence was not used at any stage in the preparation of this manuscript.</p></fn><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">OARS</term><def><p>Older Americans Resources and Services</p></def></def-item><def-item><term id="abb2">QoL</term><def><p>quality of life</p></def></def-item><def-item><term id="abb3">VR</term><def><p>virtual reality</p></def></def-item><def-item><term id="abb4">WHOQoL-OLD</term><def><p>World Health Organization Quality of Life of older adults</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>van Leeuwen</surname><given-names>KM</given-names> </name><name name-style="western"><surname>van Loon</surname><given-names>MS</given-names> </name><name name-style="western"><surname>van Nes</surname><given-names>FA</given-names> </name><etal/></person-group><article-title>What does quality of life mean to older adults? A thematic synthesis</article-title><source>PLoS One</source><year>2019</year><volume>14</volume><issue>3</issue><fpage>e0213263</fpage><pub-id pub-id-type="doi">10.1371/journal.pone.0213263</pub-id><pub-id pub-id-type="medline">30849098</pub-id></nlm-citation></ref><ref id="ref2"><label>2</label><nlm-citation citation-type="web"><article-title>Ageing and health</article-title><source>World Health Organization</source><year>2024</year><access-date>2025-01-10</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://www.who.int/news-room/fact-sheets/detail/ageing-and-health">https://www.who.int/news-room/fact-sheets/detail/ageing-and-health</ext-link></comment></nlm-citation></ref><ref id="ref3"><label>3</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Mendoza-Ruvalcaba</surname><given-names>NM</given-names> </name><name name-style="western"><surname>Arias-Merino</surname><given-names>ED</given-names> </name></person-group><article-title>&#x201C;I am active&#x201D;: effects of a program to promote active aging</article-title><source>Clin Interv Aging</source><year>2015</year><volume>10</volume><fpage>829</fpage><lpage>837</lpage><pub-id pub-id-type="doi">10.2147/CIA.S79511</pub-id><pub-id pub-id-type="medline">26005337</pub-id></nlm-citation></ref><ref id="ref4"><label>4</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Pes</surname><given-names>GM</given-names> </name><name name-style="western"><surname>Dore</surname><given-names>MP</given-names> </name></person-group><article-title>Understanding the impact of motor activity on the mental well-being of older people</article-title><source>Int Psychogeriatr</source><year>2021</year><month>12</month><volume>33</volume><issue>12</issue><fpage>1237</fpage><lpage>1239</lpage><pub-id pub-id-type="doi">10.1017/S1041610220003701</pub-id><pub-id pub-id-type="medline">34105445</pub-id></nlm-citation></ref><ref id="ref5"><label>5</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Depp</surname><given-names>C</given-names> </name><name name-style="western"><surname>Vahia</surname><given-names>IV</given-names> </name><name name-style="western"><surname>Jeste</surname><given-names>D</given-names> </name></person-group><article-title>Successful aging: focus on cognitive and emotional health</article-title><source>Annu Rev Clin Psychol</source><year>2010</year><volume>6</volume><issue>1</issue><fpage>527</fpage><lpage>550</lpage><pub-id pub-id-type="doi">10.1146/annurev.clinpsy.121208.131449</pub-id><pub-id pub-id-type="medline">20192798</pub-id></nlm-citation></ref><ref id="ref6"><label>6</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Liu-Ambrose</surname><given-names>T</given-names> </name><name name-style="western"><surname>Barha</surname><given-names>C</given-names> </name><name name-style="western"><surname>Falck</surname><given-names>RS</given-names> </name></person-group><article-title>Active body, healthy brain: exercise for healthy cognitive aging</article-title><source>Int Rev Neurobiol</source><year>2019</year><volume>147</volume><fpage>95</fpage><lpage>120</lpage><pub-id pub-id-type="doi">10.1016/bs.irn.2019.07.004</pub-id><pub-id pub-id-type="medline">31607364</pub-id></nlm-citation></ref><ref id="ref7"><label>7</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Skurla</surname><given-names>MD</given-names> </name><name name-style="western"><surname>Rahman</surname><given-names>AT</given-names> </name><name name-style="western"><surname>Salcone</surname><given-names>S</given-names> </name><etal/></person-group><article-title>Virtual reality and mental health in older adults: a systematic review</article-title><source>Int Psychogeriatr</source><year>2022</year><month>02</month><volume>34</volume><issue>2</issue><fpage>143</fpage><lpage>155</lpage><pub-id pub-id-type="doi">10.1017/S104161022100017X</pub-id><pub-id pub-id-type="medline">33757619</pub-id></nlm-citation></ref><ref id="ref8"><label>8</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Mao</surname><given-names>Q</given-names> </name><name name-style="western"><surname>Zhao</surname><given-names>Z</given-names> </name><name name-style="western"><surname>Yu</surname><given-names>L</given-names> </name><name name-style="western"><surname>Zhao</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Wang</surname><given-names>H</given-names> </name></person-group><article-title>The effects of virtual reality-based reminiscence therapies for older adults with cognitive impairment: systematic review</article-title><source>J Med Internet Res</source><year>2024</year><month>11</month><day>12</day><volume>26</volume><fpage>e53348</fpage><pub-id pub-id-type="doi">10.2196/53348</pub-id><pub-id pub-id-type="medline">39531267</pub-id></nlm-citation></ref><ref id="ref9"><label>9</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Hamid</surname><given-names>S</given-names> </name><name name-style="western"><surname>Faith</surname><given-names>F</given-names> </name><name name-style="western"><surname>Jaafar</surname><given-names>Z</given-names> </name><name name-style="western"><surname>Abdul Ghani</surname><given-names>N</given-names> </name><name name-style="western"><surname>Yusop</surname><given-names>FD</given-names> </name></person-group><article-title>Emerging technology for healthy lifestyle of the middle-age and elderly: a scoping review</article-title><source>Iran J Public Health</source><year>2023</year><month>02</month><volume>52</volume><issue>2</issue><fpage>230</fpage><lpage>242</lpage><pub-id pub-id-type="doi">10.18502/ijph.v52i2.11877</pub-id><pub-id pub-id-type="medline">37089153</pub-id></nlm-citation></ref><ref id="ref10"><label>10</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Tortora</surname><given-names>C</given-names> </name><name name-style="western"><surname>Di Crosta</surname><given-names>A</given-names> </name><name name-style="western"><surname>La Malva</surname><given-names>P</given-names> </name><etal/></person-group><article-title>Virtual reality and cognitive rehabilitation for older adults with mild cognitive impairment: a systematic review</article-title><source>Ageing Res Rev</source><year>2024</year><month>01</month><volume>93</volume><fpage>102146</fpage><pub-id pub-id-type="doi">10.1016/j.arr.2023.102146</pub-id><pub-id pub-id-type="medline">38036103</pub-id></nlm-citation></ref><ref id="ref11"><label>11</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Xie</surname><given-names>Z</given-names> </name><name name-style="western"><surname>Chen</surname><given-names>F</given-names> </name><name name-style="western"><surname>Zou</surname><given-names>L</given-names> </name><name name-style="western"><surname>Wang</surname><given-names>F</given-names> </name><name name-style="western"><surname>Yang</surname><given-names>L</given-names> </name></person-group><article-title>Using virtual reality in the care of older adults with dementia: a randomized controlled trial</article-title><source>J Gerontol Nurs</source><year>2023</year><month>11</month><volume>49</volume><issue>11</issue><fpage>25</fpage><lpage>32</lpage><pub-id pub-id-type="doi">10.3928/00989134-20231011-01</pub-id><pub-id pub-id-type="medline">37906042</pub-id></nlm-citation></ref><ref id="ref12"><label>12</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Diniz</surname><given-names>JL</given-names> </name><name name-style="western"><surname>Oliveira</surname><given-names>NMC</given-names> </name><name name-style="western"><surname>Coutinho</surname><given-names>JFV</given-names> </name><name name-style="western"><surname>Marques</surname><given-names>MB</given-names> </name><name name-style="western"><surname>Pillon</surname><given-names>CB</given-names> </name><name name-style="western"><surname>Ara&#x00FA;jo</surname><given-names>&#x00CD; de</given-names> </name></person-group><article-title>Purposes and characteristics of virtual reality technologies for the elderly in the community: a scoping review</article-title><source>Rev Lat Am Enfermagem</source><year>2024</year><volume>32</volume><fpage>e4389</fpage><pub-id pub-id-type="doi">10.1590/1518-8345.7419.4389</pub-id><pub-id pub-id-type="medline">39607177</pub-id></nlm-citation></ref><ref id="ref13"><label>13</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Tsai</surname><given-names>YC</given-names> </name><name name-style="western"><surname>Hsu</surname><given-names>WL</given-names> </name><name name-style="western"><surname>Kantha</surname><given-names>P</given-names> </name><name name-style="western"><surname>Chen</surname><given-names>PJ</given-names> </name><name name-style="western"><surname>Lai</surname><given-names>DM</given-names> </name></person-group><article-title>Virtual reality skateboarding training for balance and functional performance in degenerative lumbar spine disease</article-title><source>J Neuroeng Rehabil</source><year>2024</year><month>05</month><day>9</day><volume>21</volume><issue>1</issue><fpage>74</fpage><pub-id pub-id-type="doi">10.1186/s12984-024-01357-2</pub-id><pub-id pub-id-type="medline">38724981</pub-id></nlm-citation></ref><ref id="ref14"><label>14</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Johansen</surname><given-names>T</given-names> </name><name name-style="western"><surname>Matre</surname><given-names>M</given-names> </name><name name-style="western"><surname>L&#x00F8;vstad</surname><given-names>M</given-names> </name><etal/></person-group><article-title>Virtual reality as a method of cognitive training of processing speed, working memory, and sustained attention in persons with acquired brain injury: a protocol for a randomized controlled trial</article-title><source>Trials</source><year>2024</year><month>05</month><day>22</day><volume>25</volume><issue>1</issue><fpage>340</fpage><pub-id pub-id-type="doi">10.1186/s13063-024-08178-7</pub-id><pub-id pub-id-type="medline">38778411</pub-id></nlm-citation></ref><ref id="ref15"><label>15</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Choi</surname><given-names>JB</given-names> </name><name name-style="western"><surname>Cho</surname><given-names>KI</given-names> </name></person-group><article-title>Effects of virtual reality-based robot therapy combined with task-oriented therapy on upper limb function and cerebral cortex activation in patients with stroke</article-title><source>Medicine (Baltimore)</source><year>2024</year><month>07</month><day>5</day><volume>103</volume><issue>27</issue><fpage>e38723</fpage><pub-id pub-id-type="doi">10.1097/MD.0000000000038723</pub-id><pub-id pub-id-type="medline">38968539</pub-id></nlm-citation></ref><ref id="ref16"><label>16</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Lima Reb&#x00EA;lo</surname><given-names>F</given-names> </name><name name-style="western"><surname>de Souza Silva</surname><given-names>LF</given-names> </name><name name-style="western"><surname>Don&#x00E1;</surname><given-names>F</given-names> </name><name name-style="western"><surname>Sales Barreto</surname><given-names>A</given-names> </name><name name-style="western"><surname>de Souza Siqueira Quintans</surname><given-names>J</given-names> </name></person-group><article-title>Immersive virtual reality is effective in the rehabilitation of older adults with balance disorders: a randomized clinical trial</article-title><source>Exp Gerontol</source><year>2021</year><month>07</month><day>1</day><volume>149</volume><fpage>111308</fpage><pub-id pub-id-type="doi">10.1016/j.exger.2021.111308</pub-id><pub-id pub-id-type="medline">33744393</pub-id></nlm-citation></ref><ref id="ref17"><label>17</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Szczepocka</surname><given-names>E</given-names> </name><name name-style="western"><surname>Mokros</surname><given-names>&#x0141;</given-names> </name><name name-style="western"><surname>Kazmierski</surname><given-names>J</given-names> </name><etal/></person-group><article-title>The effectiveness of virtual reality-based training on cognitive, social, and physical functioning in high-functioning older adults (CoSoPhy FX): 2-arm, parallel-group randomized controlled trial</article-title><source>JMIR Res Protoc</source><year>2024</year><month>06</month><day>5</day><volume>13</volume><fpage>e53261</fpage><pub-id pub-id-type="doi">10.2196/53261</pub-id><pub-id pub-id-type="medline">38837194</pub-id></nlm-citation></ref><ref id="ref18"><label>18</label><nlm-citation citation-type="confproc"><person-group person-group-type="author"><name name-style="western"><surname>Lin</surname><given-names>CX</given-names> </name><name name-style="western"><surname>Lee</surname><given-names>C</given-names> </name><name name-style="western"><surname>Lally</surname><given-names>D</given-names> </name><name name-style="western"><surname>Coughlin</surname><given-names>JF</given-names> </name></person-group><article-title>Impact of virtual reality (VR) experience on older adults&#x2019; well-being</article-title><year>2018</year><conf-name>International Conference on Human Aspects of IT for the Aged Population</conf-name><conf-date>Jul 15-20, 2018</conf-date><conf-loc>Las Vegas, NV</conf-loc><publisher-name>Springer</publisher-name><fpage>89</fpage><lpage>100</lpage><pub-id pub-id-type="doi">10.1007/978-3-319-92037-5_8</pub-id></nlm-citation></ref><ref id="ref19"><label>19</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Montana</surname><given-names>JI</given-names> </name><name name-style="western"><surname>Matamala-Gomez</surname><given-names>M</given-names> </name><name name-style="western"><surname>Maisto</surname><given-names>M</given-names> </name><etal/></person-group><article-title>The benefits of emotion regulation interventions in virtual reality for the improvement of wellbeing in adults and older adults: a systematic review</article-title><source>J Clin Med</source><year>2020</year><month>02</month><day>12</day><volume>9</volume><issue>2</issue><fpage>500</fpage><pub-id pub-id-type="doi">10.3390/jcm9020500</pub-id><pub-id pub-id-type="medline">32059514</pub-id></nlm-citation></ref><ref id="ref20"><label>20</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Buele</surname><given-names>J</given-names> </name><name name-style="western"><surname>Varela-Ald&#x00E1;s</surname><given-names>JL</given-names> </name><name name-style="western"><surname>Palacios-Navarro</surname><given-names>G</given-names> </name></person-group><article-title>Virtual reality applications based on instrumental activities of daily living (iADLs) for cognitive intervention in older adults: a systematic review</article-title><source>J Neuroeng Rehabil</source><year>2023</year><month>12</month><day>19</day><volume>20</volume><issue>1</issue><fpage>168</fpage><pub-id pub-id-type="doi">10.1186/s12984-023-01292-8</pub-id><pub-id pub-id-type="medline">38110970</pub-id></nlm-citation></ref><ref id="ref21"><label>21</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Hussain</surname><given-names>F</given-names> </name><name name-style="western"><surname>Farooqui</surname><given-names>S</given-names> </name><name name-style="western"><surname>Khan</surname><given-names>AA</given-names> </name><name name-style="western"><surname>Khan</surname><given-names>MU</given-names> </name><name name-style="western"><surname>Khan</surname><given-names>MA</given-names> </name><name name-style="western"><surname>Hasan</surname><given-names>A</given-names> </name></person-group><article-title>Effects of nonimmersive virtual reality using Wii-Fit exercises on balance and cognition in Parkinson disease: a meta-analysis</article-title><source>Medicine (Abingdon)</source><year>2024</year><volume>103</volume><issue>30</issue><fpage>e38940</fpage><pub-id pub-id-type="doi">10.1097/MD.0000000000038940</pub-id></nlm-citation></ref><ref id="ref22"><label>22</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Yilmaz</surname><given-names>N</given-names> </name><name name-style="western"><surname>K&#x00F6;sehasano&#x011F;ullar&#x0131;</surname><given-names>M</given-names> </name></person-group><article-title>The effectiveness of virtual reality exercise games on balance functions and fear of falling in women with osteoporosis</article-title><source>Rheumatol Int</source><year>2024</year><month>06</month><volume>44</volume><issue>6</issue><fpage>1071</fpage><lpage>1076</lpage><pub-id pub-id-type="doi">10.1007/s00296-024-05569-6</pub-id><pub-id pub-id-type="medline">38519809</pub-id></nlm-citation></ref><ref id="ref23"><label>23</label><nlm-citation citation-type="web"><person-group person-group-type="author"><collab>IDESCAT</collab></person-group><source>Instituto de Estad&#x00ED;stica de Catalu&#x00F1;a</source><year>2024</year><access-date>2025-03-21</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://www.idescat.cat/emex/?id=431613&#x0026;lang=es">https://www.idescat.cat/emex/?id=431613&#x0026;lang=es</ext-link></comment></nlm-citation></ref><ref id="ref24"><label>24</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Grau Fibla</surname><given-names>G</given-names> </name><name name-style="western"><surname>Eiroa Pati&#x00F1;o</surname><given-names>P</given-names> </name><name name-style="western"><surname>Cayuela Dom&#x00ED;nguez</surname><given-names>A</given-names> </name></person-group><article-title>Versi&#x00F3;n espa&#x00F1;ola del OARS Multidimensional Functional Assessment Questionnaire: adaptaci&#x00F3;n transcultural y medida de la validez [Spanish version of the OARS Multidimensional Functional Assessment Questionnaire: cross-cultural adaptation and validity measurement]</article-title><source>Aten Primaria</source><year>1996</year><volume>17</volume><issue>8</issue><fpage>486</fpage><lpage>495</lpage></nlm-citation></ref><ref id="ref25"><label>25</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Mart&#x00ED;nez de la Iglesia</surname><given-names>J</given-names> </name><name name-style="western"><surname>On&#x00ED;s Vilches</surname><given-names>MC</given-names> </name><name name-style="western"><surname>Due&#x00F1;as Herrero</surname><given-names>R</given-names> </name><name name-style="western"><surname>Albert Colomer</surname><given-names>C</given-names> </name><name name-style="western"><surname>Aguado Tabern&#x00E9;</surname><given-names>C</given-names> </name><name name-style="western"><surname>Luque Luque</surname><given-names>R</given-names> </name></person-group><article-title>Versi&#x00F3;n espa&#x00F1;ola del cuestionario de Yesavage abreviado (GDS) para el despistaje de depresi&#x00F3;n en mayores de 65 a&#x00F1;os: adaptaci&#x00F3;n y validaci&#x00F3;n [Article in Spanish]</article-title><source>Medifam</source><year>2002</year><volume>12</volume><issue>10</issue><fpage>26</fpage><lpage>40</lpage><pub-id pub-id-type="doi">10.4321/S1131-57682002001000003</pub-id></nlm-citation></ref><ref id="ref26"><label>26</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Li</surname><given-names>X</given-names> </name><name name-style="western"><surname>Zhang</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Tang</surname><given-names>L</given-names> </name><name name-style="western"><surname>Ye</surname><given-names>L</given-names> </name><name name-style="western"><surname>Tang</surname><given-names>M</given-names> </name></person-group><article-title>Effects of virtual reality-based interventions on cognitive function, emotional state, and quality of life in patients with mild cognitive impairment: a meta-analysis</article-title><source>Front Neurol</source><year>2025</year><volume>16</volume><fpage>1496382</fpage><pub-id pub-id-type="doi">10.3389/fneur.2025.1496382</pub-id></nlm-citation></ref><ref id="ref27"><label>27</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Marrugat</surname><given-names>J</given-names> </name><name name-style="western"><surname>Vila</surname><given-names>J</given-names> </name><name name-style="western"><surname>Pavesi</surname><given-names>M</given-names> </name><name name-style="western"><surname>Sanz</surname><given-names>F</given-names> </name></person-group><article-title>Estimation of the sample size in clinical and epidemiological investigations</article-title><source>Med Clin (Barc)</source><year>1998</year><month>09</month><day>12</day><volume>111</volume><issue>7</issue><fpage>267</fpage><lpage>276</lpage><pub-id pub-id-type="medline">9789243</pub-id></nlm-citation></ref><ref id="ref28"><label>28</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Power</surname><given-names>M</given-names> </name><name name-style="western"><surname>Quinn</surname><given-names>K</given-names> </name><name name-style="western"><surname>Schmidt</surname><given-names>S</given-names> </name><collab>WHOQOL-OLD Group</collab></person-group><article-title>Development of the WHOQOL-OLD module</article-title><source>Qual Life Res</source><year>2005</year><month>12</month><volume>14</volume><issue>10</issue><fpage>2197</fpage><lpage>2214</lpage><pub-id pub-id-type="doi">10.1007/s11136-005-7380-9</pub-id><pub-id pub-id-type="medline">16328900</pub-id></nlm-citation></ref><ref id="ref29"><label>29</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Group</surname><given-names>E</given-names> </name></person-group><article-title>EuroQol - a new facility for the measurement of health-related quality of life</article-title><source>Health Policy</source><year>1990</year><month>12</month><volume>16</volume><issue>3</issue><fpage>199</fpage><lpage>208</lpage><pub-id pub-id-type="doi">10.1016/0168-8510(90)90421-9</pub-id></nlm-citation></ref><ref id="ref30"><label>30</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Ware</surname><given-names>JE</given-names> </name><name name-style="western"><surname>Sherbourne</surname><given-names>CD</given-names> </name></person-group><article-title>The MOS 36-ltem Short-Form Health Survey (SF-36)</article-title><source>Med Care</source><year>1992</year><month>06</month><volume>30</volume><issue>6</issue><fpage>473</fpage><lpage>483</lpage><pub-id pub-id-type="doi">10.1097/00005650-199206000-00002</pub-id></nlm-citation></ref><ref id="ref31"><label>31</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Healy</surname><given-names>D</given-names> </name><name name-style="western"><surname>Flynn</surname><given-names>A</given-names> </name><name name-style="western"><surname>Conlan</surname><given-names>O</given-names> </name><name name-style="western"><surname>McSharry</surname><given-names>J</given-names> </name><name name-style="western"><surname>Walsh</surname><given-names>J</given-names> </name></person-group><article-title>Older adults&#x2019; experiences and perceptions of immersive virtual reality: systematic review and thematic synthesis</article-title><source>JMIR Serious Games</source><year>2022</year><month>12</month><day>6</day><volume>10</volume><issue>4</issue><fpage>e35802</fpage><pub-id pub-id-type="doi">10.2196/35802</pub-id><pub-id pub-id-type="medline">36472894</pub-id></nlm-citation></ref><ref id="ref32"><label>32</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Kalantari</surname><given-names>S</given-names> </name><name name-style="western"><surname>Xu</surname><given-names>TB</given-names> </name><name name-style="western"><surname>Mostafavi</surname><given-names>A</given-names> </name><etal/></person-group><article-title>Using immersive virtual reality to enhance social interaction among older adults: a cross-site investigation</article-title><source>Innov Aging</source><year>2023</year><volume>7</volume><issue>4</issue><fpage>igad031</fpage><pub-id pub-id-type="doi">10.1093/geroni/igad031</pub-id><pub-id pub-id-type="medline">37213325</pub-id></nlm-citation></ref><ref id="ref33"><label>33</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Song</surname><given-names>X</given-names> </name><name name-style="western"><surname>Ali</surname><given-names>NM</given-names> </name><name name-style="western"><surname>Mhd Salim</surname><given-names>MH</given-names> </name><name name-style="western"><surname>Rezaldi</surname><given-names>MY</given-names> </name></person-group><article-title>A literature review of virtual reality exergames for older adults: enhancing physical, cognitive, and social health</article-title><source>Appl Sci (Basel)</source><year>2025</year><volume>15</volume><issue>1</issue><fpage>351</fpage><pub-id pub-id-type="doi">10.3390/app15010351</pub-id></nlm-citation></ref><ref id="ref34"><label>34</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Matsangidou</surname><given-names>M</given-names> </name><name name-style="western"><surname>Solomou</surname><given-names>T</given-names> </name><name name-style="western"><surname>Frangoudes</surname><given-names>F</given-names> </name><etal/></person-group><article-title>Affective out-world experience via virtual reality for older adults living with mild cognitive impairments or mild dementia</article-title><source>Int J Environ Res Public Health</source><year>2023</year><month>02</month><day>7</day><volume>20</volume><issue>4</issue><fpage>2919</fpage><pub-id pub-id-type="doi">10.3390/ijerph20042919</pub-id><pub-id pub-id-type="medline">36833616</pub-id></nlm-citation></ref><ref id="ref35"><label>35</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Dockx</surname><given-names>K</given-names> </name><name name-style="western"><surname>Bekkers</surname><given-names>EM</given-names> </name><name name-style="western"><surname>Van den Bergh</surname><given-names>V</given-names> </name><etal/></person-group><article-title>Virtual reality for rehabilitation in Parkinson&#x2019;s disease</article-title><source>Cochrane Database Syst Rev</source><year>2016</year><month>12</month><day>21</day><volume>12</volume><issue>12</issue><fpage>CD010760</fpage><pub-id pub-id-type="doi">10.1002/14651858.CD010760.pub2</pub-id><pub-id pub-id-type="medline">28000926</pub-id></nlm-citation></ref><ref id="ref36"><label>36</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Coyle</surname><given-names>H</given-names> </name><name name-style="western"><surname>Traynor</surname><given-names>V</given-names> </name><name name-style="western"><surname>Solowij</surname><given-names>N</given-names> </name></person-group><article-title>Computerized and virtual reality cognitive training for individuals at high risk of cognitive decline: systematic review of the literature</article-title><source>Am J Geriatr Psychiatry</source><year>2015</year><month>04</month><volume>23</volume><issue>4</issue><fpage>335</fpage><lpage>359</lpage><pub-id pub-id-type="doi">10.1016/j.jagp.2014.04.009</pub-id><pub-id pub-id-type="medline">24998488</pub-id></nlm-citation></ref><ref id="ref37"><label>37</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Lange</surname><given-names>BS</given-names> </name><name name-style="western"><surname>Requejo</surname><given-names>P</given-names> </name><name name-style="western"><surname>Flynn</surname><given-names>SM</given-names> </name><etal/></person-group><article-title>The potential of virtual reality and gaming to assist successful aging with disability</article-title><source>Phys Med Rehabil Clin N Am</source><year>2010</year><month>05</month><volume>21</volume><issue>2</issue><fpage>339</fpage><lpage>356</lpage><pub-id pub-id-type="doi">10.1016/j.pmr.2009.12.007</pub-id><pub-id pub-id-type="medline">20494281</pub-id></nlm-citation></ref></ref-list><app-group><supplementary-material id="app1"><label>Multimedia Appendix 1</label><p>RATE-XR information.</p><media xlink:href="resprot_v14i1e74298_app1.docx" xlink:title="DOCX File, 14 KB"/></supplementary-material><supplementary-material id="app2"><label>Multimedia Appendix 2</label><p>Rivas-Borda Quality of Life Scale.</p><media xlink:href="resprot_v14i1e74298_app2.docx" xlink:title="DOCX File, 18 KB"/></supplementary-material><supplementary-material id="app3"><label>Multimedia Appendix 3</label><p>Satisfaction questionnaire.</p><media xlink:href="resprot_v14i1e74298_app3.docx" xlink:title="DOCX File, 14 KB"/></supplementary-material><supplementary-material id="app4"><label>Multimedia Appendix 4</label><p>Table S1. Description of the variables and the source of information about the Rivas-Borda Quality of Life Scale.</p><media xlink:href="resprot_v14i1e74298_app4.docx" xlink:title="DOCX File, 15 KB"/></supplementary-material></app-group></back></article>