Coronary artery disease (CAD) is a major global health issue, significantly contributing to both illness and death [1,2]. In the United States, heart disease is the leading cause of death, with CAD being the primary contributor [3]. CAD significantly impacts overall health care expenditure and incurs additional costs beyond direct medical expenses, such as lost productivity from premature death and disability [4,5]. Key risk factors for CAD include hypertension, diabetes, dyslipidemia, smoking, and physical inactivity [6,7]. These factors accelerate atherosclerosis, a complex condition involving endothelial dysfunction, abnormal lipid metabolism, and inflammatory mechanisms, leading to the accumulation of low-density lipoprotein and other inflammatory particles that form fatty streaks and plaques prone to rupture [6-8]. There are notable disparities in CAD prevalence across different demographics. For example, CAD prevalence increases with age, with only 1% of adults aged 18-44 years reporting CAD, compared to 24.2% of adults aged 75 years and older [9]. Gender differences are also significant, with men reporting higher rates of CAD than women [10]. From 2009 to 2019, 7% of men reported CAD in 2019 compared to 4.2% of women [10]. Black and Hispanic populations face greater risks, partly due to higher rates of hypertension, diabetes, and obesity [11].

Socioeconomic factors also play a critical role; individuals from lower socioeconomic backgrounds often have limited access to health care, nutritious food, and opportunities for physical activity, increasing their risk for CAD [12,13]. Although insurance coverage is not reported to influence CAD prevalence, factors such as education level and income are reported to have a significant impact [14].

In recent decades, many health care organizations have launched executive health programs tailored specifically for the medical care of professionals in leadership roles [15-17]. Unlike traditional primary care, these programs place a stronger emphasis on preventive care, particularly cardiovascular screening with advanced lipid testing, cardiac stress testing, and coronary artery calcium scan, which are not routinely implemented in primary care [15-17]. Some programs also offer access to emerging disease screening technologies, including predictive genetic testing, pharmacogenomic screening, blood-based multi-cancer screening, and whole-body magnetic resonance imaging [16]. The overarching goal of these programs is to identify health risks and diseases early, promote overall wellness, and provide efficient, accessible health care with a strong focus on disease prevention [15-17].

The target demographic for these executive health programs are typically individuals who hold major leadership positions in corporations, businesses, and trusts, including business owners and entrepreneurs, who often face demanding and stressful professional schedules, such as C-suite executives, senior management, board members, trustees, founders, and business owners, all of whom collectively drive economic activity and contribute significantly to the overall health of the economy [15-17]. Although executives generally have better access to health care, higher incomes, and higher educational levels compared to the general population, they also face high-stress work environments that often interfere with their ability to maintain healthy lifestyle habits [15-19]. Additionally, there are demographic variations between this population and the general population. For instance, in terms of race and ethnicity, executive health program participants often reflect a more homogeneous group, frequently from higher socioeconomic backgrounds, which can influence health outcomes [20]. Gender disparities are notable as well, with a predominance of male participants, aligning with the typical gender distribution in executive roles [20]. The age group of these individuals typically ranges from 40 to 60 years—a period during which the risk for CAD significantly increases [14].

This combination of factors underscores the need to investigate CAD prevalence among executives to develop targeted interventions tailored to their unique needs. However, there are currently no published data on these factors or the prevalence of CAD among executives, representing a critical gap in the literature. We aim to conduct a retrospective cohort study to determine the prevalence of CAD among individuals enrolled in an executive health program at a large medical center.

A total of 24,272 patients were identified as having been seen in the Executive Health Clinic at Mayo Clinic in Rochester between January 1, 2020, and December 31, 2023. After confirming research authorization and executive status and excluding individuals younger than 21 years or older than 75 years, 6466 patients met the inclusion criteria. Of these, 3290 patients had a mention of CAD in their medical records. This subset of medical records will undergo a secondary review to confirm the diagnosis of CAD and abstract variables as outlined in the study protocol.

This study seeks to address a significant gap in the literature by evaluating the prevalence of CAD within an executive health population—a group that has been largely understudied despite its unique risk profile. Although CAD prevalence is well-characterized in the general US population, its burden among executives remains unclear [14,24]. Given the distinct demographic, occupational, and lifestyle characteristics of this group, we hypothesize that CAD prevalence may differ meaningfully from that of the broader population. Executives often experience elevated levels of work-related stress, irregular schedules, and limited time for physical activity, all of which are known contributors to cardiovascular risk [19,20]. These factors suggest a potential for higher CAD prevalence in this population. Conversely, patients in executive health programs typically have enhanced access to preventive services than what is offered in routine primary care, including routine cardiovascular screening and personalized education, which may facilitate early detection of subclinical disease or even reduce overall disease burden through proactive risk management [15-17]. As such, the observed prevalence may reflect a complex interplay between increased risk exposure and improved access to care.

Two recent studies have described the prevalence of CAD in the US population by using different methodologies. In the first study, Lee et al [14] evaluated CAD prevalence in the United States from 2011 to 2018 by using data from the Behavioral Risk Factor Surveillance System, where individuals self-reported CAD via telephone surveys. The authors reported an overall CAD prevalence of 5.8%-6.2% in the US population [14]. The prevalence was higher in men compared to women (7.7% vs 4.6%, respectively) and in adults older than 65 years compared to those younger than 45 years (7.4% vs 1.6%, respectively) [14]. Notably, there was a clear discrepancy based on income, with lower CAD prevalence in higher-income individuals compared to those with lower incomes (4.1% vs 8.9%, respectively) [14]. In the second study, Khalid et al [24] used data from the Centers for Disease Control and Prevention’s National Center for Health Statistics to evaluate CAD prevalence trends from 2019 to 2022. They reported an overall CAD prevalence of 4.6%-4.9% in the US population, with higher prevalence in males compared to females (6.4% vs 3.6%, respectively) and in adults older than 75 years compared to those aged 65-74 years, 45-64 years, and 18-44 years (19.7% vs 12.3% vs 4.1% vs 0.5%, respectively) [24]. Both studies [14,24] reported disparities in CAD prevalence among different racial and ethnic groups. Lee et al [14] highlighted American Indian or Alaska Native individuals as having the highest prevalence, while Khalid et al [24] found White adults had the highest prevalence. Both studies relied on self-reported data (telephone and interview surveys) to determine CAD presence, which could result in missed diagnoses among individuals who did not participate in the survey, who were unaware of their diagnosis, or who did not engage in primary and preventative care [14,24]. Compared to these 2 studies, although our proposed study focuses only on executives and not on the general population, our proposed methodology is superior in that it relies on documentation in medical records, reducing the likelihood of missed diagnoses. Additionally, our patient population participates in routine cardiovascular prevention beyond what is typically offered in primary care, further lowering the chance of undiagnosed CAD. This distinguishes our methodology and underscores the significance of our study.

This proposed study is crucial for several reasons. Given the lack of literature on CAD within executives, our study aims to address this significant gap and may be the first to evaluate CAD prevalence within this population. If our findings show a higher prevalence of CAD among executives, it may indicate that our executive health program provides superior screening or that executives face higher CAD risks due to stress and lifestyle factors. Conversely, a lower prevalence might reflect the benefits of enhanced care in executive health programs. Additionally, there are limited data on health conditions specific to executives, and this research could prompt further studies on executive health profiles. Finally, understanding CAD prevalence among executives can help health care providers tailor screening practices and optimize interventions for this group, especially if the prevalence is higher than in the general population.

As with other retrospective cohort studies, our study has several limitations. First, there is the potential for missing or inconsistent data, as medical records may be incomplete or vary in documentation quality. Second, selection bias may be present, as the cohort reflects only those executives who chose to participate in our program and may not be representative of the broader executive population. Additionally, our sample characteristics may differ substantially from those of a community-based medical sample or the US general population. As a result, any observed differences in CAD prevalence may reflect the self-selected nature of our cohort rather than true population-level differences. Third, we recognize that stress may be a predictive variable for CAD. However, data related to stress are not routinely collected in the executive health population and are therefore not readily available in the medical records. This limitation may affect our ability to fully assess the role of psychosocial factors in CAD prevalence. Fourth, the retrospective nature of the study limits our ability to control for the confounding variables, which may influence both the quantitative and qualitative aspects of the data collected. Despite these limitations, our study has several notable strengths. It leverages real-world clinical data collected at a world-class medical institution, offering valuable insights into how CAD is diagnosed and managed in routine executive practice. The inclusion of 3 years of data enhances the robustness of our findings by capturing patients who may not attend annually and increasing the likelihood of identifying CAD diagnoses that may have been missed in a single year. Additionally, our reliance on clinician-documented diagnoses, rather than self-reported data or survey responses, improves the accuracy and clinical relevance of our findings.

This proposed study aims to fill a critical gap in health literature by evaluating CAD prevalence among executives, potentially guiding tailored screening practices and interventions to improve cardiovascular outcomes in this unique population. Our study findings will be submitted to a peer-reviewed journal to ensure rigorous academic dissemination. If the opportunity arises, the results will also be presented at national and international conferences to reach a broader academic and clinical audience.