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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">ResProt</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Res Protoc</journal-id>
      <journal-title>JMIR Research Protocols</journal-title>
      <issn pub-type="epub">1929-0748</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v14i1e63015</article-id>
      <article-id pub-id-type="pmid">39808788</article-id>
      <article-id pub-id-type="doi">10.2196/63015</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Protocol</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Protocol</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Value Cocreation and Codestruction in Digital Health Services: Protocol for a Systematic Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Schwartz</surname>
            <given-names>Amy</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Arriaga</surname>
            <given-names>Rosa</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Laukka</surname>
            <given-names>Elina</given-names>
          </name>
          <degrees>RN, PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Department of Public Health</institution>
            <institution>Faculty of Medicine</institution>
            <institution>University of Helsinki</institution>
            <addr-line>PO Box 00020</addr-line>
            <addr-line>Helsinki, 00014</addr-line>
            <country>Finland</country>
            <phone>358 503380111</phone>
            <email>elina.laukka@helsinki.fi</email>
          </address>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-3959-8591</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Tuunanen</surname>
            <given-names>Tuure</given-names>
          </name>
          <degrees>Prof Dr</degrees>
          <xref rid="aff3" ref-type="aff">3</xref>
          <xref rid="aff4" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-7119-1412</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Jansson</surname>
            <given-names>Miia</given-names>
          </name>
          <degrees>RN, PhD</degrees>
          <xref rid="aff5" ref-type="aff">5</xref>
          <xref rid="aff6" ref-type="aff">6</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-5815-0325</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Vanhanen</surname>
            <given-names>Minna</given-names>
          </name>
          <degrees>RN, PhD</degrees>
          <xref rid="aff7" ref-type="aff">7</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-7771-9756</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Hirvonen</surname>
            <given-names>Nina</given-names>
          </name>
          <degrees>BSc</degrees>
          <xref rid="aff8" ref-type="aff">8</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0008-0632-7705</ext-link>
        </contrib>
        <contrib id="contrib6" contrib-type="author">
          <name name-style="western">
            <surname>Palukka</surname>
            <given-names>Jenni</given-names>
          </name>
          <degrees>BSc</degrees>
          <xref rid="aff8" ref-type="aff">8</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0005-8487-8674</ext-link>
        </contrib>
        <contrib id="contrib7" contrib-type="author">
          <name name-style="western">
            <surname>Vesinurm</surname>
            <given-names>Märt</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff8" ref-type="aff">8</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-7351-7834</ext-link>
        </contrib>
        <contrib id="contrib8" contrib-type="author">
          <name name-style="western">
            <surname>Torkki</surname>
            <given-names>Paulus</given-names>
          </name>
          <degrees>Prof Dr</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-1127-4205</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Department of Public Health</institution>
        <institution>Faculty of Medicine</institution>
        <institution>University of Helsinki</institution>
        <addr-line>Helsinki</addr-line>
        <country>Finland</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>School of Culture and Wellbeing</institution>
        <institution>Oulu University of Applied Sciences</institution>
        <addr-line>Oulu</addr-line>
        <country>Finland</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>Faculty of Information Technology</institution>
        <institution>University of Jyväskylä</institution>
        <addr-line>Jyväskylä</addr-line>
        <country>Finland</country>
      </aff>
      <aff id="aff4">
        <label>4</label>
        <institution>Department of Informatics and Media</institution>
        <institution>Uppsala University</institution>
        <addr-line>Uppsala</addr-line>
        <country>Sweden</country>
      </aff>
      <aff id="aff5">
        <label>5</label>
        <institution>Research Unit of Health Sciences and Technology</institution>
        <institution>University of Oulu</institution>
        <addr-line>Oulu</addr-line>
        <country>Finland</country>
      </aff>
      <aff id="aff6">
        <label>6</label>
        <institution>RMIT University</institution>
        <addr-line>Melbourne</addr-line>
        <country>Australia</country>
      </aff>
      <aff id="aff7">
        <label>7</label>
        <institution>Focus Area for Digital Solutions</institution>
        <institution>Centre for Research and Innovation</institution>
        <institution>Oulu University of Applied Sciences</institution>
        <addr-line>Oulu</addr-line>
        <country>Finland</country>
      </aff>
      <aff id="aff8">
        <label>8</label>
        <institution>Institute of Healthcare Engineering and Management at the Department of Industrial Engineering and Management</institution>
        <institution>Aalto University School of Science</institution>
        <addr-line>Espoo</addr-line>
        <country>Finland</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Elina Laukka <email>elina.laukka@helsinki.fi</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2025</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>14</day>
        <month>1</month>
        <year>2025</year>
      </pub-date>
      <volume>14</volume>
      <elocation-id>e63015</elocation-id>
      <history>
        <date date-type="received">
          <day>11</day>
          <month>6</month>
          <year>2024</year>
        </date>
        <date date-type="rev-request">
          <day>4</day>
          <month>9</month>
          <year>2024</year>
        </date>
        <date date-type="rev-recd">
          <day>15</day>
          <month>10</month>
          <year>2024</year>
        </date>
        <date date-type="accepted">
          <day>3</day>
          <month>12</month>
          <year>2024</year>
        </date>
      </history>
      <copyright-statement>©Elina Laukka, Tuure Tuunanen, Miia Jansson, Minna Vanhanen, Nina Hirvonen, Jenni Palukka, Märt Vesinurm, Paulus Torkki. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 14.01.2025.</copyright-statement>
      <copyright-year>2025</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on https://www.researchprotocols.org, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://www.researchprotocols.org/2025/1/e63015" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>To successfully design, develop, implement, and deliver digital health services that provide value, they should be cocreated with patients. However, occasionally, the value may also be codestructed. In the field of health care, the concepts of value cocreation and codestruction still need to be better established within emerging digital health services. Studying these concepts is essential for developing effective and sustainable patient-centered care.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>The aim of the study is (1) to understand the antecedents, decisions, and outcomes of value cocreation and codestruction in digital health services, (2) to define the dynamics between value cocreation and codestruction, and (3) to map future research areas of value cocreation and codestruction within digital health services.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>The systematic review will be conducted in accordance with the Joanna Briggs Institute methodology for mixed method systematic reviews and the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. The review considers scientific qualitative, quantitative, or mixed method studies published in English, Finnish, or Swedish that concern either value cocreation or codestruction in digital health services. Studies focusing on physical robotics and online health communities, as well as non–peer-reviewed and nonscientific papers, will be excluded. The searches were conducted using Scopus and MEDLINE during this protocol creation. Critical appraisal will be done using suitable checklists for qualitative, quantitative, and mixed method studies. The review will adhere to a convergent integrated approach as outlined in the Joanna Briggs Institute methodology for mixed methods systematic reviews.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>The searches resulted in a total of 837 records. The antecedents, decisions, and outcomes of value cocreation and codestruction in the context of digital health services will be described in a finalized systematic review. In the outcomes, our main interest is the effect on patient outcomes and experiences and professional experiences.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>Since our study involves diverse scientific fields, there is a risk that our search does not capture all relevant papers. To mitigate this risk, we used 2 large databases for the searches. In addition, the value cocreation or codestruction terms may not have been used in all studies focusing on the collaborative roles of patients and providers, especially in the medical field, and that may be difficult to capture. The review reveals the current understanding of value cocreation and codestruction in digital health services and shapes the research agenda for these phenomena. Value cocreation can be used to both design and efficiently use digital health services trying to maximize the value for patients.</p>
        </sec>
        <sec sec-type="registered-report">
          <title>International Registered Report Identifier (IRRID)</title>
          <p>DERR1-10.2196/63015</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>value cocreation</kwd>
        <kwd>value codestruction</kwd>
        <kwd>telemedicine</kwd>
        <kwd>eHealth</kwd>
        <kwd>systematic review</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <p>Value cocreation and customers’ interactive roles in the service exchange have been essential to understanding how value is created in services [<xref ref-type="bibr" rid="ref1">1</xref>]. Rapid technological advances and digital transformation are transforming the context in which value is created [<xref ref-type="bibr" rid="ref2">2</xref>]. Health care services had a significant transformation as digital health services rapidly expanded during the COVID-19 pandemic [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>]. Digital health services can be defined as the use of information and communication technologies in health care products, services, and processes [<xref ref-type="bibr" rid="ref5">5</xref>]. Digital services, including telemedicine interventions, mobile health apps, and remote monitoring devices, have been suggested as a potential solution to tackle issues related to accessibility, availability, and health care costs [<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref7">7</xref>]. In addition to the technical development, it also changes the way of thinking and how services are provided and perceived [<xref ref-type="bibr" rid="ref4">4</xref>].</p>
      <p>Cocreation, a burgeoning paradigm within management literature, facilitates the joint creation of value by enterprises and consumers through interactive processes [<xref ref-type="bibr" rid="ref8">8</xref>]. Since the onset of the 21st century, the concept of cocreation has proliferated extensively, evidenced in scholarly discourse and empirical inquiries, thereby challenging established tenets of capitalist economies. In such economies, value traditionally tends to be predetermined prior to market transactions [<xref ref-type="bibr" rid="ref8">8</xref>,<xref ref-type="bibr" rid="ref9">9</xref>]. Health care is a complex service where defining and operationalizing value presents significant challenges [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref11">11</xref>]. Since Porter [<xref ref-type="bibr" rid="ref12">12</xref>] introduced the idea of measuring health care value as patient-relevant outcomes per costs associated with the health problem, the concept has been widely discussed for its potential to unify the objectives of various stakeholders [<xref ref-type="bibr" rid="ref11">11</xref>]. In the context of digital health services, value may be more closely related to outcomes and experiences, with costs being more pertinent at the system level.</p>
      <p>From the standpoint of cocreation, suppliers and customers are no longer perceived as adversaries but rather as collaborators engaging with each other to foster the emergence of novel business prospects [<xref ref-type="bibr" rid="ref13">13</xref>]. During the last decade, Yi and Gong [<xref ref-type="bibr" rid="ref14">14</xref>] established the significance of value cocreation behavior, which provides a multidimensional framework encompassing diverse value cocreation activities, such as information seeking, information sharing, responsible behavior, and personal interaction, that help explain how customers and firms, or patients and health care providers in this case, interact and collaborate.</p>
      <p>Additionally, the digitalization of services within health care ecosystems is altering how value is created, delivered, experienced, and evaluated [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref16">16</xref>]. Understanding value cocreation and the interactive roles of customers in the service exchange is crucial for comprehending how value is created in services [<xref ref-type="bibr" rid="ref1">1</xref>], with value cocreation being conceptualized as a joint problem-solving process [<xref ref-type="bibr" rid="ref17">17</xref>]. For instance, value cocreation in digital health services can be depicted through customer engagement, encompassing emotional, active, and cognitive dimensions [<xref ref-type="bibr" rid="ref18">18</xref>].</p>
      <p>However, value is not always cocreated. Value codestruction signifies that not all interactions and relationships yield positive or value-creating results; occasionally, these engagements may even lead to adverse outcomes [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref20">20</xref>]. Value codestruction refers to an interactive process between service systems that leads to a reduction in the well-being of at least 1 of the systems, which can affect either individuals or organizations depending on the nature of the service system [<xref ref-type="bibr" rid="ref20">20</xref>]. For example, value codestruction may manifest in the inability to search for, understand, and use health information gathered on the web [<xref ref-type="bibr" rid="ref21">21</xref>]. Additionally, the assumption that telemedicine can negatively impact doctor-patient relationships inevitably leads to value-in-use destruction [<xref ref-type="bibr" rid="ref21">21</xref>].</p>
      <p>As digital services differ significantly from traditional services, there is a need to understand how to enhance value cocreation between a service provider and its users in digital services [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref23">23</xref>]. Tuunanen et al [<xref ref-type="bibr" rid="ref23">23</xref>] identified 5 mechanisms to support value cocreation in the design of digital services, namely social use, customer orientation and decision-making, service experience, service use context, and customer values and goals.</p>
      <p>In response to evolving population needs, it is evident that the role of patients within digital health services and health care at large has transitioned toward a collaborative partnership between professionals and patients [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref25">25</xref>]. According to Huber et al [<xref ref-type="bibr" rid="ref26">26</xref>], the definition of health is also changing from “complete mental, physical, and social well-being” toward “the ability to self-manage and adapt.” According to van Druten et al [<xref ref-type="bibr" rid="ref27">27</xref>], a similar multifaceted approach to Huber’s concept of positive health was shared by many perspectives. Nevertheless, upon closer examination, it was observed that the core elements of positive health, namely “the ability to adapt and to self-manage,” were also acknowledged in other health concepts, regardless of perspective. These health concepts described “the ability to adapt” as, for instance, adjusting to changing physical conditions like aging, illness, or disability, maintaining emotional balance, and viewing health as a dynamic state requiring adaptation to circumstances. “The ability to self-manage” was often described as autonomy or independence. Through the value cocreation process, professionals and patients can make a significant contribution to health outcomes as partners [<xref ref-type="bibr" rid="ref28">28</xref>]. For example, patients can provide perspectives on areas of the care process that are invisible to health care professionals [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref30">30</xref>]. Previous literature has discussed many consequences of value cocreation related to health outcomes, service experience, perceived service quality, and service engagement [<xref ref-type="bibr" rid="ref31">31</xref>].</p>
      <p>While value cocreation has also been studied in health care, less attention has been given to the investigation of value codestruction [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref32">32</xref>]. As the field of health care is constantly becoming more digitalized, examining value cocreation and value codestruction in digital services would provide valuable insights into developing such services. Peng et al [<xref ref-type="bibr" rid="ref31">31</xref>] conducted a systematic review of value cocreation in health care and digital services before the COVID-19 pandemic. They also encouraged researchers to explore further opportunities for value cocreation in both web-based and hybrid environments. Even so, the review by Peng et al [<xref ref-type="bibr" rid="ref31">31</xref>] did not address value codestruction, which, in conjunction with value cocreation, could aid in enhancing the efficiency of digital health services. Several authors have highlighted the necessity of gaining a more comprehensive understanding of value codestruction and integrating it with the research on value cocreation [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref34">34</xref>]. Considering the pandemic’s impact on digital service expansion [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>], increasing resource constraints due to rising chronic illnesses, and aging populations [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref36">36</xref>], conducting a new systematic literature review could provide a contemporary perspective on value cocreation in health care. Furthermore, this review aims to provide a more comprehensive understanding of value codestruction.</p>
      <p>So as to gain a more current understanding of both value cocreation and value codestruction in digital health services, this review seeks to identify scientific studies published between 2020 and 2024, using the Joanna Briggs Institute’s (JBI) guidance for mixed method systematic reviews [<xref ref-type="bibr" rid="ref37">37</xref>] and adhering to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist for reporting systematic reviews [<xref ref-type="bibr" rid="ref38">38</xref>] The objectives of the review will be (1) to understand the antecedents, decisions, and outcomes (ADO) of value cocreation and value codestruction, (2) to define the dynamics between value cocreation and value codestruction in digital health services, and (3) to map future research areas of value cocreation and value codestruction within digital health services. To answer the first research question, this review uses a systematic literature review framework, namely, the ADO framework by Paul and Benito [<xref ref-type="bibr" rid="ref39">39</xref>]. The ADO framework aims to identify the known aspect of any phenomenon, which in the case of this review is value cocreation and value codestruction in the context of digital health services. Our research questions are (1) What are the ADO of value cocreation and value codestruction in digital health services? (2) What are the dynamics between value cocreation and value codestruction in digital health services? (3) What are the most promising future research areas in value cocreation and value codestruction within digital health services?</p>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Overview</title>
        <p>The systematic review will be conducted in accordance with the JBI methodology for mixed method systematic review [<xref ref-type="bibr" rid="ref37">37</xref>] and the PRISMA statement [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>] (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>). This protocol has been registered in PROSPERO (International Prospective Register of Systematic Reviews; 549303). During this review protocol, the searches have been conducted, but the screening, quality assessment, and analysis will be carried out in the finalized systematic review.</p>
      </sec>
      <sec>
        <title>Search Strategy</title>
        <p>Using the search strategy developed by Peng et al [<xref ref-type="bibr" rid="ref31">31</xref>] as a foundation, adjustments were made to include value codestruction. The search strategy aimed to identify peer-reviewed scientific studies and was conducted in 3 steps. First, to ensure an optimal search strategy for both value cocreation and value codestruction, an initial limited search of MEDLINE and Scopus was conducted on May 21, 2024, which resulted in 48 and 247 papers, respectively. MEDLINE and Scopus were selected since they collectively provide extensive coverage of publications on digital health services, value cocreation, and value codestruction. Second, relevant papers were identified through title, abstract, and index term analysis. An information specialist was consulted during the development of the final search strategy. Keywords were truncated as necessary, and index terms such as MeSH were used in MEDLINE (<xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>). Additionally, the reference lists of all included studies will be screened to identify additional relevant studies.</p>
      </sec>
      <sec>
        <title>Eligibility Criteria</title>
        <p>This study will include studies that investigate either value cocreation, value codestruction, or both in digital health services. This review will consider scientific qualitative, quantitative, or mixed method studies. Papers published in English, Finnish, and Swedish will be eligible for inclusion. Only papers published between January 1, 2020, and the present (June 2024) concerning value cocreation were considered, as an earlier review covered the period from 2008 to 2019 [<xref ref-type="bibr" rid="ref31">31</xref>]. Regarding value codestruction, the limitation period extends from January 1, 2008, to December 31, 2008, since the earlier review did not address value codestruction. Studies focusing on physical robotics, as well as non–peer-reviewed and nonscientific papers, will be excluded.</p>
      </sec>
      <sec>
        <title>Study Selection</title>
        <p>The results of the search are presented in a PRISMA flow diagram [<xref ref-type="bibr" rid="ref38">38</xref>]. All citations identified through the described search strategy were compiled and uploaded into Rayyan (Al Rayyan Company), which was also used to remove duplicate entries. Titles and abstracts will then undergo independent screening by 2 team members (NH and JP) using predefined inclusion and exclusion criteria. For papers lacking abstracts, the full text will be obtained. Following the title and abstract screening, potentially relevant studies will be retrieved in full. Two independent reviewers (NH and JP) will thoroughly assess these studies and determine their suitability based on the inclusion criteria. Exclusion reasons will be documented for studies that do not meet the inclusion criteria. Any discrepancies during the study selection or any other process will be resolved through discussion or by consulting a third team member (EL and PT). All search methods, strategies, and sources will be detailed or named in the final report, ensuring replicability.</p>
      </sec>
      <sec>
        <title>Assessment of Methodological Quality</title>
        <p>Before being included in the review, papers will undergo evaluation by 2 separate reviewers (EL and M Vanhanen) to ensure methodological soundness. We will use the JBI checklists for qualitative and quantitative studies and the Mixed Methods Appraisal Tool for mixed method studies [<xref ref-type="bibr" rid="ref41">41</xref>]. In cases where necessary, authors of papers will be contacted to request missing or additional data to ensure clarity. The outcomes of critical appraisal will be presented both in narrative form and in a table format. Data extraction and synthesis will be conducted for all studies, irrespective of their methodological quality assessment outcomes, whenever feasible.</p>
      </sec>
      <sec>
        <title>Data Extraction and Synthesis</title>
        <p>Two independent reviewers (EL and M Vanhanen) will extract both quantitative and qualitative data from the studies included in the review. The extracted data will encompass specific details about populations, study methods, phenomena of interest, context, and outcomes relevant to the review questions. Quantitative data will include outcomes derived from descriptive and inferential statistical tests. Additionally, qualitative data will comprise verbatim themes or subthemes accompanied by corresponding illustrations and will be assigned a level of credibility. Authors of papers will be contacted up to a maximum of 2 times to request missing or additional data, as necessary.</p>
      </sec>
      <sec>
        <title>Data Transformation</title>
        <p>The quantitative data will undergo a process of “qualitization,” which entails transforming it into textual descriptions or narrative interpretations that directly address the review questions.</p>
      </sec>
      <sec>
        <title>Data Synthesis and Integration</title>
        <p>This review will adhere to a convergent integrated approach as outlined in the JBI methodology for mixed methods systematic reviews. This approach involves integrating the qualitized data with the qualitative data. The assembled data will be categorized and pooled based on similarity in meaning, ultimately generating a set of integrated findings presented as the line of action statements. We will classify the data using the ADO framework [<xref ref-type="bibr" rid="ref39">39</xref>]. Additionally, we will synthesize the current knowledge of each dimension and formulate a future research agenda based on the findings.</p>
      </sec>
      <sec>
        <title>Ethical Considerations</title>
        <p>Since concept analyses solely rely on secondary publicly available data sourced from primary research studies, there is no requirement for research ethics approval.</p>
      </sec>
      <sec>
        <title>Validity and Rigor</title>
        <p>The following activities will be performed to enhance the review’s validity and rigor:</p>
        <list list-type="order">
          <list-item>
            <p>Method: The systematic review will be conducted following the JBI guidelines [<xref ref-type="bibr" rid="ref37">37</xref>] and following the PRISMA statement [<xref ref-type="bibr" rid="ref38">38</xref>].</p>
          </list-item>
          <list-item>
            <p>Search: To increase the reliability of the review, an information specialist with expertise in health care, value cocreation, and value codestruction will be consulted. Additionally, several database sources will be included in the final search to ensure the richness of the data to be analyzed.</p>
          </list-item>
          <list-item>
            <p>Screening, data extraction, and synthesis: Each of the previously mentioned phases will be conducted independently by at least 2 independent team members (NH and JP), which will enhance the reliability of the review.</p>
          </list-item>
          <list-item>
            <p>Process: The research team members (EL, TT, M Vanhanen, NH, JP, MJ, M Vesinurm, and PT) will continuously review the paper during ongoing meetings throughout the process.</p>
          </list-item>
        </list>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <p>The review started in May 2024 and will be completed in a time frame of 8 months. This time phase includes the following phases: screening, data extraction, quality assessment, and data synthesis. The literature search was conducted entirely during the review protocol process and reported in the PRISMA diagram. The final search in MEDLINE and Scopus on June 6, 2024, resulted in 58 and 770 papers, respectively (<xref rid="figure1" ref-type="fig">Figure 1</xref>). As Peng et al [<xref ref-type="bibr" rid="ref31">31</xref>] omitted value codestruction in their search, a supplementary search focusing exclusively on value codestruction was conducted on September 19, 2024, covering the years 2008 to 2019. This search yielded 9 papers from Scopus and none from MEDLINE. In total, 837 records were detected. The systematic review is anticipated to be ready for submission by December 2024.</p>
      <fig id="figure1" position="float">
        <label>Figure 1</label>
        <caption>
          <p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram.</p>
        </caption>
        <graphic xlink:href="resprot_v14i1e63015_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
      </fig>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>Our review will reveal the current understanding of value cocreation and codestruction in digital health services and shape the research agenda for these phenomena. In their review, Peng et al [<xref ref-type="bibr" rid="ref31">31</xref>] focused on studies published prior to the COVID-19 pandemic, a period after which the number of digital health services has significantly increased. Consequently, our review will provide the most recent insights into value cocreation and value codestruction within digital health services. The ADO framework [<xref ref-type="bibr" rid="ref39">39</xref>] assists in producing a knowledge map outlining the associations between ADO of value cocreation and codestruction in the context of digital health services. The ADO of value cocreation and codestruction will be described. In the outcomes, our main interest is the effect on patient outcomes and experiences and professional experiences. The more detailed results will be determined based on the finalized review.</p>
        <p>Value cocreation can be used in both designing as well as the efficient use of digital health services trying to maximize value for patients. In other digital services, value cocreation and codestruction have been studied more thoroughly, as most of the services nowadays are digital, and the world has already been described as digital-first [<xref ref-type="bibr" rid="ref42">42</xref>].</p>
        <p>As the field of health care is constantly more digitalized, examining value cocreation and codestruction in digital services would provide valuable insights into developing such services. To support the cost-effectiveness of the services and try to minimize the effects of digital exclusivity, it is crucial to understand value cocreation and codestruction better in digital health services.</p>
      </sec>
      <sec>
        <title>Strengths and Limitations</title>
        <p>Since our study is crossing the scientific fields, there is a risk that our search does not capture all relevant papers. To mitigate this risk, we include multiple databases for the searches. However, only peer-reviewed studies will be included in this review, which excludes gray literature [<xref ref-type="bibr" rid="ref43">43</xref>]. In addition, the value cocreation or codestruction terms may not have been used in all studies focusing on the collaborative roles of patients and providers, especially in the medical field, and that may be difficult to capture.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>PRISMA-S (Preferred Reporting Items for Systematic reviews and Meta-Analyses Literature Search Extension) checklist.</p>
        <media xlink:href="resprot_v14i1e63015_app1.doc" xlink:title="DOC File , 159 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Search strategy.</p>
        <media xlink:href="resprot_v14i1e63015_app2.doc" xlink:title="DOC File , 164 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">ADO</term>
          <def>
            <p>antecedents, decisions, and outcomes</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">JBI</term>
          <def>
            <p>Joanna Briggs Institute</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">PRISMA</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">PROSPERO</term>
          <def>
            <p>International Prospective Register of Systematic Reviews</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>The authors would like to thank Aalto University Library for consulting with the search strategy. Open access is funded by the Helsinki University Library.</p>
    </ack>
    <notes>
      <sec>
        <title>Data Availability</title>
        <p>The datasets generated and analyzed during this study are available from the corresponding author on reasonable request.</p>
      </sec>
    </notes>
    <fn-group>
      <fn fn-type="con">
        <p>The review protocol was conceived and supervised by EL and PT. EL, TT, MJ, M Vanhanen, NH, JP, M Vesinurm, and PT planned the review and formed the aim and research question. PT, NH, and JP developed the search strategy and conducted the search. EL, NH, JP, and PT screened papers. EL and PT drafted the main text. All authors contributed revisions.</p>
      </fn>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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