The inclusion criteria adopted were the following: (1) patients between 18 and 65 years of age with IA; (2) a diagnosis of PD or GAD through the Mini International Psychiatric Interview (MINI), and confirmed by a psychiatrist; (3) attending and completing the initial interview; and (4) having sufficient cognitive ability to understand the instructions. Patients who did not know how to read or write, or had Axis II pathology [6], were excluded.

This study was approved by the Ethics Committee of The Federal University of Rio de Janeiro, CAAE 2704531460000526. All patients signed a consent form and attended the Laboratory of Panic and Respiration at the Institute of Psychiatry of the Federal University of Rio de Janeiro (IPUB/UFRJ).

All patients were seeking treatment for anxiety symptoms. At screening, they responded to the following scales: MINI 5.0 [70], the Hamilton Anxiety Rating Scale (HAM-A) [71], the Hamilton Depression Rating Scale (HDRS) [72], Clinical Global Impressions Scale (CGI) [73], and the Young Internet Addiction Test (IAT) [10]. IA was assessed through the IAT (scores above 50), while anxiety disorders were diagnosed by a psychiatrist. Patients were then invited to participate in this study and were forwarded for pharmacotherapy and a modified CBT protocol.

Patients were evaluated by a psychiatrist at the beginning of treatment, were permitted to take medication prescribed by the psychiatrist during treatment, and were accompanied by a psychiatrist throughout treatment.

All 39 patients underwent psychotherapy (modified CBT), which was conducted once a week for 10 weeks. The focus was to teach patients how to manage anxiety symptoms without using the Internet, and to promote conscious use of the Internet. Psychotherapy followed 4 phases: psychoeducation about anxiety and Internet use, cognitive reappraisal, behavioral modification, and prevention of relapse (Table 1).

The first phase of psychotherapy lasts 3 sessions and is focused on psychoeducation about the anxiety mechanism, identifying frightening situations, and triggers that increase anxiety and problematic Internet use. The focus is on teaching breathing retraining through breathing exercises and strategies, without using the Internet to deal with anxious thoughts and situations. During this phase, patients learn to identify and accept emotions and to stop fighting against their anxiety. Patients come to understand their anxiety and its relationship to Internet use through self-monitoring of their Internet use during situations involving anxiety. Other maintenance factors related to Internet abuse and anxiety are also explored. These factors can include personal, situational, social, psychiatric, or occupational conditions.

The second phase pertains to cognitive reappraisal of anxiety and Internet use. During this stage, patients think about their daily Internet use, cognitions involved in this use, and anxiety. Cognitive distortions are identified and the patient comes to understand that distortions such as the following contribute to their excessive use of the Internet: “Just a few more minutes on the Internet won’t do me any harm”; “I have to answer my friends immediately, otherwise they will not forgive me”; “If my friends don’t give “likes” on my posts or my photos, it is a signal that they don’t like me or that I did something wrong”; and “If I disconnect from the Internet, I will miss important things because the best things are on the Internet.” All thoughts related to anxiety and Internet use are restructured and new thoughts are proposed; alternative beliefs are generated over 2 sessions.

The third phase (3 sessions) involves behavioral modification with exposure to feared/ansiogenic situations, time management training, and proposal of a diary of Internet use. Behavioral modification involves breaking routines in the use of the Internet, and includes changing ways of dealing with family, friends, social activities, physical exercise, and other aspects of life. All components of situations are analyzed, and replaced or removed as necessary to do things differently and successfully change old ways of functioning. Another important element of this stage is the insertion of positive emotions into daily activities to develop social skills, so as to promote less Internet usage and more in-person interactions. According to positive psychology, enhancing positive emotion increases resilience, helping to reduce signs and symptoms of anxiety and depression and prevent relapse [74].

The fourth phase lasts 2 sessions with a focus on continued recovery and relapse prevention by reinforcing new beliefs and behaviors, and social skills such as assertiveness, problem solving, verbal communication, and empathy. Achievements/improvements are registered on a card (achievement card) and patients are encouraged to continue putting into practice what they have learned in psychotherapy. In the last session, volunteers responded to the same scales used at the start of treatment (IAT, HAM-A, HAM-D, and CGI), to follow up and verify improvements in scale scores. In addition to improvements in scale scores, other important criteria were reduced time spent on the Internet, increased in-person interactions, and in particular, reduced need to use the Internet to escape from problems or manage anxiety.

This open trial study proposed pharmacological and psychotherapeutic interventions to treat patients diagnosed with PD or GAD and IA. Initially, 41 patients fulfilled criteria and were selected to receive psychotherapy treatment for PD or GAD and IA; however, two did not proceed with treatment (a 33-year-old male taxi driver with PD and IA who moved to another state after the third session; and a 36-year-old female with PD and IA as well as other diagnoses such as an eating disorder and recurrent depression, who attended only 2 sessions of psychotherapy). The other 39 patients attended all sessions; demographic characteristics are presented in Table 2.

Psychiatrists prescribed medications to treat PD or GAD and IA. Some of the medications used were antidepressants such as fluoxetine, sertraline, venlafaxine, desvenlafaxine, paroxetine, escitalopram, zolpidem, and duloxetine; anxiolytics such as clonazepam and alprazolam; psychostimulants such as methylphenidate; and antipsychotics such as quetiapine.

Of the 39 patients, 25 were diagnosed with PD and 14 with GAD, besides also having IA. Before treatment, anxiety levels on the HAM-A suggested severe anxiety, with an average score of 34.26 (SD 6.13); after treatment, the average score was 15.03 (SD 3.88). The IAT average score at the beginning of treatment was 67.67 (SD 7.69), indicating problematic Internet use; after the sessions, the average IAT score was 37.56 (SD 9.32), indicating moderate Internet use and a significate improvement in addiction. The mean HDRS score at baseline was 16.72 (SD 5.56), suggesting mild depression, whereas after treatment the mean score was 7.28 (SD 2.52), indicating no depression. Results of the t tests comparing scores before and after treatment are reported in Table 3.

Correlations between scale scores were also computed. The correlation between scores on the IAT and HAM-A was .724, between scores on the HAM-A and HDRS was .815, and between scores on the IAT and HDRS was .535.

At the end of psychotherapy, all patients felt very positive about their treatment and were very confident, after having recovered their social lives. Patients showed improvements in anxiety symptoms and managing anxiety without use of the Internet. Internet use after treatment became conscious and all patients were classified as mild users. These achievements show that patients were able to recover healthy functioning.

In the present study, the authors described a protocol for modified CBT treatment, examined the effects of this treatment and pharmacotherapy on 39 patients with PD/GAD and IA, and analyzed the relationship between anxiety and IA. Despite controversy regarding the recognition of IA as an official disorder, the harmful effects of this behavioral addiction are highlighted in several studies [75-80]. The psychotherapy protocol was shown to be effective in the treatment of anxiety and IA, since all patients learned to manage anxiety without the Internet and showed conscious use at the end of the sessions.

Several studies have confirmed the association between depression and IA [19-23,27]; however, few studies have explored the association between anxiety and IA [26,81,82]. Imaging studies indicate that IA functions similarly to impulse control disorder; magnetic resonance imaging has shown that the areas activated when an individual with IA has the urge to use the Internet are the same areas activated by addictive substances [5]. At the same time, anxiety plays an important role in increasing Internet usage and strengthening the addiction. The authors highlighted the relationship between anxiety disorders and IA through the correlation shown (.724), which reflects the fact that beliefs and behaviors related to anxiety have an important impact on Internet use and contact with the world.

Previous treatments for IA have been described in the literature such as CBT [45,56,60,83], CBT and medication [59,67,68], and multimodal programs involving individual and group therapy, counselling, and family therapy [44,61,84].

A limitation of the study was the small sample size (39 participants); however, results showed the effectiveness of the proposed treatment, both in reducing symptoms of anxiety and promoting healthy Internet use, to improve IA in patients. Furthermore, this study is the first published research on IA treatment in a Brazilian population.

Future research should identify possible treatments for IA using new strategies and approaches, such as gestalt, counselling, family therapy, mindfulness, psychodynamic therapies, positive psychology, and transdiagnostic treatment. Investigation and analysis should also be conducted to develop new treatments for specific populations in which IA has a harmful impact, such as couples with marital problems, individuals who suffer from insomnia, individuals with attention deficit disorder, and individuals with other addictive behaviors, such as smoking, drug use, eating, sex, or shopping.

Our findings suggest that pharmacotherapy and the developed protocol of psychotherapy in the treatment of patients with anxiety and IA were effective strategies. Improvement was remarkable due to complete engagement of patients in therapy, which contributed to the success of treatment from a behavioral perspective, and gave patients confidence to continue and to manage Internet use in their lives.

IA is increasing around the world and in some countries, such as South Korea and China, it is considered a public health condition. In this sense, effective treatments should be proposed and reported that promote conscious use of the Internet, and involve valuing family, friends, a social life, and physical exercise. As such, Internet use should be conscious so as not to become abuse, and interaction over the Internet should reinforce and expand in-person interactions.