JMIR Research Protocols
Ongoing Trials, Grant Proposals, Formative Research, Methods, Early Results
JMIR Research Protocols (ISSN 1929-0748) publishes peer-reviewed, openly accessible research ideas and grant proposals, study and trial protocols, reports of ongoing research, current methods and approaches, and preliminary results from pilot studies or formative research informing the design of medical and health-related research and technology innovations.
JMIR Res Protoc is a new journal spin-off of JMIR, the worlds' leading medical journal in health sciences / health services research and health informatics (Impact Factor 2015: 4.532)
JMIR Res Protoc publishes protocols and grant proposals in all areas of medicine (and their peer-review reports, if available), as well as feasibility studies, early reports and formative/process evaluations of ongoing studies and descriptions of the development and pilot evaluations of innovations and software applications or other interventions
JMIR Res Protoc is fully open access, with full text articles deposited in PubMed Central
Publishing research protocols, grant proposals, pilot/feasibility studies and early reports of ongoing and planned work encourages collaboration and early feedback, and reduces duplication of effort
JMIR Res Protoc will be a valuable ressource for researchers who want to learn about current research methodologies and how to write a winning grant proposal
JMIR Res Protoc creates an early scientific record for researchers who have developed novel methodologies, software, innovations or elaborate protocols
JMIR Res Protoc faciliates subsequent publication of results demonstrating that the methodology has already been reviewed, and reduces the effort of writing up the results, as the protocol can be easily referenced
JMIR Res Protoc demonstrates to reviewers of subsequent results papers that authors followed and adhered to carefully developed and described a-priori methods
Studies whose protocols or grant proposal have been accepted in JMIR Res Protoc are "in principle accepted" for subsequent publication of results in other JMIR journals as long as authors adhere to their original protocol - regardless of study results (even if they are negative), reducing publication bias in medicine
Authors publishing their protocols in JMIR Res Protoc will receive a 20% discount on the article processing fee if they publish their results in another journal of the JMIR journal family (for example, JMIR for ehealth studies, i-JMR for others)
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Latest Submissions Open for Peer-Review:View All Open Peer Review Articles
High Touch and High Tech (HT2): Transforming Patient Engagement Throughout the Continuum of Care by Engaging Patients with Portal Technology at the Bedside
Date Submitted: Jul 18, 2016
Open Peer Review Period: Jul 19, 2016 - Aug 2, 2016
For patients with complex care needs, engagement in disease management activities is critical. Chronic illnesses touch almost every person in the U.S. The costs are real, personal and pervasive. In re...
For patients with complex care needs, engagement in disease management activities is critical. Chronic illnesses touch almost every person in the U.S. The costs are real, personal and pervasive. In response, patients often seek tools to help them manage their health. Patient portals -- a Personal Health Record tethered to an Electronic Health Record -- show promise as tools that patients value and that can improve health. Although patient portals currently focus on the outpatient experience, the Ohio State University Wexner Medical Center has deployed a portal designed specifically for the inpatient experience that is connected to the ambulatory patient portal available after discharge. While this inpatient technology is in active use at only one other hospital in the U.S., healthcare facilities are currently investing in infrastructure necessary to support large-scale deployment. Times of acute crisis such as hospitalization may increase a patient’s focus on his/her health. During this time, patients may be more engaged with their care and especially interested in using tools to manage their health after discharge. Evidence shows that enhanced patient self-management can lead to better control of chronic illness. Patient portals may serve as a mechanism to facilitate increased engagement. Our proposed four-year study uses a mixed-methods approach to evaluate a randomized controlled trial studying the effectiveness of a High Tech Intervention (MyChart Bedside, the inpatient portal), and an accompanying High Touch Intervention (training patients to use the portal to manage their care and conditions) in a sample of hospitalized patients with two or more chronic conditions. This study measures how access to a patient portal tailored to the inpatient stay can improve patient experience and increase patient engagement by 1) improving patients’ perceptions of the process of care while in the hospital, 2) increasing patients’ self-efficacy for managing chronic conditions, and 3) facilitating continued use of a patient portal for care management after discharge. In addition, we aim to enhance patients’ use of the portal available to outpatients, MyChart Ambulatory, once they are discharged. Our specific aims are: 1. To study the independent effects of providing both High Tech and High Touch interventions on patient-reported outcomes at discharge, including patients’ self-efficacy for managing chronic conditions and satisfaction with care. 2. To conduct a mixed-methods analysis to determine how providing patients with access to MCB (High Tech) and training/education on patient portals and MCA (High Touch) will influence engagement with the patient portal and relate to longer-term outcomes. Providing patients real-time access to health information can be a positive force for change in the way care is provided. Meaningful Use policies require minimum demonstrated use of patient portal technology, most often in the ambulatory setting. However, as the technology matures to bridge the care transition, there is a greater need to understand how patient portals transform care delivery. By working in concert with patients to address and extend current technologies, our study aims to advance efforts to increase patients’ engagement in their care and develop a template for how other hospitals might integrate similar technologies.
The effects of e-mental health program and job coaching on the risk of major depression and productivity in Canadian male workers: Protocol for a randomized controlled trial
Date Submitted: Jul 18, 2016
Open Peer Review Period: Jul 19, 2016 - Aug 2, 2016
Background: Background: Major depression (MDE) is prevalent in men and affects men’s health and productivity. Because of the stigma against depression and social/gender norms, men are less likely to...
Background: Background: Major depression (MDE) is prevalent in men and affects men’s health and productivity. Because of the stigma against depression and social/gender norms, men are less likely to seek help for emotion and stress-related issues. Therefore, innovative solutions tailored for men are needed. With rapid development of the Internet and information technologies, one promising solution that has drawn considerable attentions is e-mental health programs and services. Objective: Objectives: To evaluate the effectiveness of an e-mental health program (BroHealth) on reducing the risk of having major depression, improving productivity and return to investment. Methods: Methods: The target population are Canadian working men who are at high risk of having major depression (N = 1200). Participants will be recruited using the method of random digit dialing across the country and workplace advertisement. Eligible participants will be randomly allocated into three groups: 1) a control group, 2) a group receiving BroHealth only, and 3) a group receiving BroHealth and telephone-based job coaching service. The groups will be assessed at 6- and 12-month after randomization. Results: Results: This study has been approved by the Conjoint Health Research Ethics Review Board of the University of Calgary. The trial is funded by a team grant from the Movember Foundation, a global charity for men’s health. BroHealth was developed at the Digital Health Office, University of British Columbia, and the usability testing has been completed. The proposed trial is registered at clinicaltrials.gov (registration number: NCT02777112). Conclusions: Conclusions: BroHealth was developed based on men’s needs. We hypothesis that BroHealth will be an effective, acceptable and sustainable product for early prevention of depression in workplaces. Clinical Trial: registration number: NCT02777112
Perivascular Adipose Tissue Inflammation and Coronary Artery Disease: an Autopsy Study Protocol
Date Submitted: Jul 9, 2016
Open Peer Review Period: Jul 9, 2016 - Jul 23, 2016
Background: Perivascular adipose tissue (PAT) inflammation may have a role in coronary artery disease (CAD) pathophysiology. However, most evidence came from samples obtained during surgical procedure...
Background: Perivascular adipose tissue (PAT) inflammation may have a role in coronary artery disease (CAD) pathophysiology. However, most evidence came from samples obtained during surgical procedures that may imply in some limitations. Moreover, the role of B lymphocytes and inflammation in PAT that is adjacent to unstable atheroma plaques has not been investigated in humans using morphometric measurements. Objective: To investigate the inflammation in PAT, subcutaneous and perirenal adipose tissues (SAT and PrAT) among chronic CAD, acute CAD, and control groups in an autopsy study. Methods: Heart, SAT, and PrAT samples are collected from autopsied subjects in a general autopsy service, with the written informed consent of the next-of-kin (NOK). Sociodemographic and clinical data are obtained from a semi-structure interview with the NOK. Coronary arteries are dissected and PAT are removed. Sections with the greatest arterial obstruction or unstable plaques, and the local with absence of atherosclerosis in all coronary arteries are sampled. PAT are represented adjacent to these fragments. Adipose tissues are fixed in 4% buffered formalin and analyzed immunohistochemically for macrophages (CD68), macrophage polarization (CD11c for pro-inflammatory M1 and CD206 for anti-inflammatory M2), B lymphocytes (CD20), and T lymphocytes (CD3). Slides will be scanned, and inflammatory cells will be quantified in 20 random fields. Participants will be categorized in CAD groups, after morphometric measurement of arterial obstruction and plaque composition analysis in accordance with American Heart Association classification. Three study groups will be investigated: acute CAD (at least one unstable plaque); chronic CAD (≥ 50% arterial obstruction); and controls (< 50% arterial obstruction). Inflammatory cells in PAT, SAT, and PrAT will be counted and compared between groups using multivariate linear regression, adjusted for age, body mass index, hypertension, diabetes, alcohol use, and smoking. Results: We present the methods of our study that was developed from two pilots. Currently, data collection and tissue processing are ongoing. Data collection, histology and immunochemistry procedures, and quantification of all inflammatory cells are expected to be concluded within one year. Conclusions: This study will contribute for the understanding of the mechanisms of CAD pathophysiology since it will help to clarify the role of inflammation both in chronic and acute CAD.